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Penapisan dan Edukasi Tuberkulosis Paru pada Warga Desa Titi Akar Kecamatan Rupat Utara Nori Purnama; Dewi Anggraini; Sri Indah Indriani
ABDI: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol 6 No 4 (2024): Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Labor Jurusan Sosiologi, Fakultas Ilmu Sosial, Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/abdi.v6i4.758

ABSTRACT Tuberculosis (TB) is a contagious chronic lung disease caused by infection from the Mycobacterium tuberculosis (M.Tb) group of bacteria, which consists of eight different and interrelated species. Patients with pulmonary TB in 2021 globally amounted to 10.6 million people in the world, this figure increased by 4.5% compared to 2020, which was 10.1 million people. The highest number of TB cases in Southeast Asia is occupied by India, Indonesia, and China, followed by Africa (23%) and the Western Pacific (18%). Riau still has areas that are difficult to reach, one of which is Rupat Island which is one of the islands included in the Bengkalis Regency area. The lack of knowledge about tuberculosis to the people of Indonesia, especially in rural areas such as Titi Akar Village, North Rupat District, so health workers are obliged to provide education about tuberculosis disease and how to detect pulmonary TB disease early. Community service activities and lung health checks for residents of Titi Akar Village, North Rupat District, Bengkalis Regency, Riau Province are very useful and important for these villagers. This activity is expected to increase knowledge and know the number of patients suffering from Tuberculosis disease based on the results of doctor's examination and Molecular Rapid Test examination. Keyword : Tuberculosis, Molecular Rapid Tes, North Rupat

Argon Plasma Coagulation in Bronchoscopy: A Safe and Effective Treatment for Airway Obstruction Anggi Rizki Utami Nasution; Indra Yovi; Sri Indah Indriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1293

Background: Airway obstruction can significantly impair a patient's quality of life and even become life-threatening. Traditional treatment options, such as surgery or laser therapy, can be invasive and associated with significant complications. Argon plasma coagulation (APC) has emerged as a minimally invasive alternative for treating airway obstruction. APC uses ionized argon gas to deliver controlled thermal energy, allowing for precise tissue coagulation and ablation. This meta-analysis aims to evaluate the safety and efficacy of APC in treating airway obstruction. Methods: A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science databases. Studies published between 2013 and 2024 that evaluated the use of APC in bronchoscopy for airway obstruction were included. The primary outcomes were the success rate of APC in achieving airway patency and the incidence of complications. Results: Seven studies (n=342 patients) met the inclusion criteria. The pooled success rate of APC in achieving airway patency was 91% (95% CI, 87-94%). The overall incidence of complications was 8% (95% CI, 5-11%), with minor bleeding being the most common. Conclusion: This meta-analysis demonstrates that APC is a safe and effective treatment for airway obstruction. It offers a high success rate in restoring airway patency with a low risk of complications. APC is a valuable tool for pulmonologists in managing patients with airway obstruction.

High-Flow Nasal Cannula versus Non-Invasive Positive Pressure Ventilation in Adults with Acute Hypoxemic (Type 1) Respiratory Failure: A Meta-Analysis of Efficacy, Intubation Rates, and Mortality Muhammad Reza Arifin; Indra Yovi; Sri Indah Indriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 8 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i8.1349

Background: Acute hypoxemic respiratory failure (AHRF), or Type 1 respiratory failure, is a common life-threatening condition characterized by severe impairment in arterial oxygenation. High-flow nasal cannula (HFNC) and Non-Invasive Positive Pressure Ventilation (NIPPV) are two widely used non-invasive respiratory support strategies. However, their comparative effectiveness in adults with Type 1 AHRF remains a subject of ongoing investigation. This meta-analysis aimed to compare the efficacy, intubation rates, and mortality associated with HFNC versus NIPPV in this patient population. Methods: A systematic search of PubMed, EMBASE, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) was conducted for randomized controlled trials (RCTs) published between January 2014 and December 2024. Studies comparing HFNC with NIPPV in adult patients with Type 1 AHRF were included. The primary outcomes were the rate of endotracheal intubation and all-cause mortality (hospital or 28-day). Secondary outcomes included improvement in oxygenation (such as change in PaO2/FiO2 ratio) and length of hospital stay. Two reviewers independently screened studies, extracted data, and assessed the risk of bias using the Cochrane Risk of Bias tool. Meta-analyses were performed using a random-effects model, and results were expressed as Risk Ratios (RR) with 95% Confidence Intervals (CI) for dichotomous outcomes and Mean Differences (MD) for continuous outcomes. Heterogeneity was assessed using the I² statistic. Results: Six RCTs involving a total of 1850 patients (920 in the HFNC group and 930 in the NIPPV group) met the inclusion criteria. The overall risk of bias in the included studies was moderate. There was no statistically significant difference between HFNC and NIPPV in the rate of endotracheal intubation (RR 0.92, 95% CI 0.75-1.13; I²=28%; 6 studies) or all-cause mortality (RR 0.88, 95% CI 0.69-1.12; I²=15%; 6 studies). For oxygenation improvement, assessed by the change in PaO2/FiO2 ratio at 24 hours, data from four studies showed no significant difference between the two groups (MD 5.8 mmHg, 95% CI -8.5 to 20.1 mmHg; I²=45%). Hospital length of stay was also comparable. Subgroup analyses based on underlying etiology (such as pneumonia) did not reveal significant interactions. Conclusion: In adult patients with Type 1 acute hypoxemic respiratory failure, this meta-analysis found no significant difference between HFNC and NIPPV in terms of intubation rates, mortality, or improvement in oxygenation. Both modalities appear to be viable initial non-invasive respiratory support options. The choice between HFNC and NIPPV may depend on patient tolerance, local expertise, resource availability, and specific clinical contexts. Further large-scale, high-quality RCTs are warranted to confirm these findings and explore effects in specific patient subgroups.

Argon Plasma Coagulation in Bronchoscopy: A Safe and Effective Treatment for Airway Obstruction Anggi Rizki Utami Nasution; Indra Yovi; Sri Indah Indriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1293

Background: Airway obstruction can significantly impair a patient's quality of life and even become life-threatening. Traditional treatment options, such as surgery or laser therapy, can be invasive and associated with significant complications. Argon plasma coagulation (APC) has emerged as a minimally invasive alternative for treating airway obstruction. APC uses ionized argon gas to deliver controlled thermal energy, allowing for precise tissue coagulation and ablation. This meta-analysis aims to evaluate the safety and efficacy of APC in treating airway obstruction. Methods: A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science databases. Studies published between 2013 and 2024 that evaluated the use of APC in bronchoscopy for airway obstruction were included. The primary outcomes were the success rate of APC in achieving airway patency and the incidence of complications. Results: Seven studies (n=342 patients) met the inclusion criteria. The pooled success rate of APC in achieving airway patency was 91% (95% CI, 87-94%). The overall incidence of complications was 8% (95% CI, 5-11%), with minor bleeding being the most common. Conclusion: This meta-analysis demonstrates that APC is a safe and effective treatment for airway obstruction. It offers a high success rate in restoring airway patency with a low risk of complications. APC is a valuable tool for pulmonologists in managing patients with airway obstruction.

High-Flow Nasal Cannula versus Non-Invasive Positive Pressure Ventilation in Adults with Acute Hypoxemic (Type 1) Respiratory Failure: A Meta-Analysis of Efficacy, Intubation Rates, and Mortality Muhammad Reza Arifin; Indra Yovi; Sri Indah Indriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 8 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i8.1349

Background: Acute hypoxemic respiratory failure (AHRF), or Type 1 respiratory failure, is a common life-threatening condition characterized by severe impairment in arterial oxygenation. High-flow nasal cannula (HFNC) and Non-Invasive Positive Pressure Ventilation (NIPPV) are two widely used non-invasive respiratory support strategies. However, their comparative effectiveness in adults with Type 1 AHRF remains a subject of ongoing investigation. This meta-analysis aimed to compare the efficacy, intubation rates, and mortality associated with HFNC versus NIPPV in this patient population. Methods: A systematic search of PubMed, EMBASE, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) was conducted for randomized controlled trials (RCTs) published between January 2014 and December 2024. Studies comparing HFNC with NIPPV in adult patients with Type 1 AHRF were included. The primary outcomes were the rate of endotracheal intubation and all-cause mortality (hospital or 28-day). Secondary outcomes included improvement in oxygenation (such as change in PaO2/FiO2 ratio) and length of hospital stay. Two reviewers independently screened studies, extracted data, and assessed the risk of bias using the Cochrane Risk of Bias tool. Meta-analyses were performed using a random-effects model, and results were expressed as Risk Ratios (RR) with 95% Confidence Intervals (CI) for dichotomous outcomes and Mean Differences (MD) for continuous outcomes. Heterogeneity was assessed using the I² statistic. Results: Six RCTs involving a total of 1850 patients (920 in the HFNC group and 930 in the NIPPV group) met the inclusion criteria. The overall risk of bias in the included studies was moderate. There was no statistically significant difference between HFNC and NIPPV in the rate of endotracheal intubation (RR 0.92, 95% CI 0.75-1.13; I²=28%; 6 studies) or all-cause mortality (RR 0.88, 95% CI 0.69-1.12; I²=15%; 6 studies). For oxygenation improvement, assessed by the change in PaO2/FiO2 ratio at 24 hours, data from four studies showed no significant difference between the two groups (MD 5.8 mmHg, 95% CI -8.5 to 20.1 mmHg; I²=45%). Hospital length of stay was also comparable. Subgroup analyses based on underlying etiology (such as pneumonia) did not reveal significant interactions. Conclusion: In adult patients with Type 1 acute hypoxemic respiratory failure, this meta-analysis found no significant difference between HFNC and NIPPV in terms of intubation rates, mortality, or improvement in oxygenation. Both modalities appear to be viable initial non-invasive respiratory support options. The choice between HFNC and NIPPV may depend on patient tolerance, local expertise, resource availability, and specific clinical contexts. Further large-scale, high-quality RCTs are warranted to confirm these findings and explore effects in specific patient subgroups.

Bronchoalveolar Lavage in Interstitial Lung Disease: A Narrative Literature Review Romadani, Rizki; Sri Indah Indriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 2 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i2.918

Establishing a diagnosis of interstitial lung disease (ILD) is very important because the diagnosis of ILD is often missed with other lung diseases. Apart from clinical diagnosis of ILD, other tests are also required, such as a lung biopsy, which can be done using open lung biopsy but has high mortality and morbidity rates. Apart from that, lung biopsy can be done using video-assisted thoracoscopy (VATS) and transbronchial biopsy, but it is relatively more expensive compared to examination bronchoalveolar lavage (BAL), which is another diagnostic approach of ILD. Bronchoalveolar lavage is performed using a flexible fiber bronchoscope (fiberoptic bronchoscopy), which has a lower morbidity and mortality rate.

Pathogenesis and Minimally Invasive Management of Subcutaneous Emphysema: A Narrative Literature Review Syafitra, Said Tryanda; Sri Indah Indriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 2 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i2.928

Subcutaneous emphysema is the result of air infiltrating the subcutaneous and soft tissues. The prevalence of subcutaneous emphysema varies between 0.43% and 2.34%. Subcutaneous emphysema typically results in mild symptoms, poses no significant risk, and does not necessitate specific medical intervention. Pathologies affecting underlying tissues can exhibit greater severity and pose a risk to life. Subcutaneous emphysema is a challenge in terms of how to handle it. The treatment should initiate a focused endeavor to determine the underlying etiology of subcutaneous air dissection. This literature review focuses on subcutaneous emphysema, specifically exploring its pathogenesis and therapy strategies for people with this condition.

The Art of Diagnosis from Breath Sound: A Literature Review Ambun Suri Afdi, Tania Libristina; Sri Indah Indriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 3 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i3.943

Breath sounds provide relevant information related to lung abnormalities. It is often difficult to differentiate between breath sounds, this is due to the different characteristics of each breath sound. Differentiating the types of breath sounds is crucial in making an accurate diagnosis. Breath sounds are divided into normal breath sounds and abnormal (additional) breath sounds. Normal breath sounds are sounds that originate from the chest wall, such as tracheal, bronchial, bronchovesicular and vesicular breath sounds. Meanwhile, abnormal (additional) breath sounds are breath sounds that indicate an abnormal condition in the respiratory system. Normal and abnormal breath sounds have different characteristics such as intensity, duration, frequency, quality of air flow, air flow pattern, air distribution, body position, location of sound production, changes in pressure and vibration of dense tissue in the lungs.

Bronchoscopy Diagnostic Procedures in Central and Peripheral Lesions: A Narrative Literature Review Syaf, Syarlidina; Sri Indah Indriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 5 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i5.983

Bronchoscopy is a medical procedure that provides tracheobronchial visualization by placing a bronchoscope and is carried out by a competent doctor. Bronchoscopy is the main interventional procedure used in determining the diagnosis and staging of cancer patients and plays a role in interstitial lung disease and infections. The basic principle of bronchoscopy sampling is carried out with a combination of rinsing, brushing, needle aspiration and biopsy. Cryobiopsy has advantages over conventional forceps biopsy and electrocautery because it can produce tissue without artifacts. Navigated bronchoscopy techniques have facilitated peripheral lung tumor biopsies that have better diagnostic yield than conventional transbronchial biopsies. The combination of navigation bronchoscopy with an ultrathin bronchoscope for peripheral lesions is more effective than either modality.

Bronchoalveolar Lavage in Interstitial Lung Disease: A Narrative Literature Review Romadani, Rizki; Sri Indah Indriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 2 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i2.918

Establishing a diagnosis of interstitial lung disease (ILD) is very important because the diagnosis of ILD is often missed with other lung diseases. Apart from clinical diagnosis of ILD, other tests are also required, such as a lung biopsy, which can be done using open lung biopsy but has high mortality and morbidity rates. Apart from that, lung biopsy can be done using video-assisted thoracoscopy (VATS) and transbronchial biopsy, but it is relatively more expensive compared to examination bronchoalveolar lavage (BAL), which is another diagnostic approach of ILD. Bronchoalveolar lavage is performed using a flexible fiber bronchoscope (fiberoptic bronchoscopy), which has a lower morbidity and mortality rate.

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