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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Putri, Septia Harma
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Management of Thrombocytopenia with Partial Splenic Embolization in Liver Cirrhosis Putri, Septia Harma; Arnelis; Saptino Miro
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 6 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i6.1015

Abstract

Thrombocytopenia is a frequent complication in patients with cirrhosis. Thrombocytopenia is generally divided into mild, moderate, and severe thrombocytopenia. Thrombocytopenia in liver cirrhosis not only increases the risk of bleeding during surgery but can also have an impact on patient management, such as liver biopsy, administration of antiviral therapy, and postponement of elective surgery. The pathophysiology of thrombocytopenia in chronic liver disease can be caused by decreased platelet production, sequestration in the spleen, and increased platelet destruction. Partial splenic embolization (PSE) is one option for treating thrombocytopenia in chronic liver disease. PSE is an effective procedure in treating complications associated with hypersplenism and portal hypertension, such as esophageal varices, pancytopenia, portal hypertensive gastropathy and ascites.
Correlation Of Serum 25-Hydroxyvitamin D Levels With Glycemic Control In Type 2 Diabetes Mellitus Patients Putri, Septia Harma; Aprilia, Dinda; Decroli, Eva
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 2 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i2.18731

Abstract

ABSTRACT Background: Type 2 diabetes mellitus (T2DM) is caused by reduced insulin sensitivity, which can lead to insulin shortage. Several recent investigations have found that vitamin D is connected with insulin secretion and sensitivity. Vitamin D insufficiency is linked to poor glucose regulation. Aim: To determine the correlation between serum 25-hydroxyvitamin D levels and glycemic control in Type 2 DM patients. Method: T2DM patients' serum levels of 25-Hydroxyvitamin D, Fasting Blood Glucose (FBG), 2-hours postprandial blood glucose (2-h PBG), and HbA1c were examined in this cross-sectional analytical observational study. Statistical analysis was also performed. Result: From 49 samples included, the number of male subjects was almost the same as female, mean age was 58 years. There was a decrease in serum 25-Hydroxyvitamin D levels with a median of 27.87 ng/ml (12,626 -94,367). Glycemic control was found to be poor, the median of FBG levels was 134 mg/dl (61-339), 2-h PBG levels was 208 mg/dl (93-488) and HbA1c levels was 7.5% (5.6-12.8). Analysis using Spearman correlation between serum 25-Hydroxyvitamin D levels with levels of FBG, 2-h PBG and HbA1c showed values of r = -0.538 and p = 0.000, r = -0.354 and p 0.013, r = -0.501 and p 0.000. Conclusion: There was a statistically significant negative correlation between serum 25-Hydroxyvitamin D levels and levels of FBP, 2h-PBG and HbA1c in T2DM patients. Keywords: 25-Hydroxyvitamin D serum, glycemic control, fasting blood glucose, two-hour postprandial blood glucose, HbA1c.
Management of Thrombocytopenia with Partial Splenic Embolization in Liver Cirrhosis Putri, Septia Harma; Arnelis; Saptino Miro
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 6 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i6.1015

Abstract

Thrombocytopenia is a frequent complication in patients with cirrhosis. Thrombocytopenia is generally divided into mild, moderate, and severe thrombocytopenia. Thrombocytopenia in liver cirrhosis not only increases the risk of bleeding during surgery but can also have an impact on patient management, such as liver biopsy, administration of antiviral therapy, and postponement of elective surgery. The pathophysiology of thrombocytopenia in chronic liver disease can be caused by decreased platelet production, sequestration in the spleen, and increased platelet destruction. Partial splenic embolization (PSE) is one option for treating thrombocytopenia in chronic liver disease. PSE is an effective procedure in treating complications associated with hypersplenism and portal hypertension, such as esophageal varices, pancytopenia, portal hypertensive gastropathy and ascites.
Co-Authors Aprilia, Dinda Arnelis Eva Decroli Saptino Miro