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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research
Rachmad Faisal
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Analysis of the Role of Vitamin C Hypovitaminosis in Scurvy on Bone Health: A Single Center Observational Study at Dr. Moewardi General Hospital, Surakarta, Indonesia Nefihancoro, Udi Heru; Rachmad Faisal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1066

Abstract

Background: Scurvy, vitamin C deficiency, is a rare condition but remains relevant in Indonesia. This study aims to analyze the role of vitamin C hypovitaminosis in the development of scurvy and its impact on bone health through an observational study at Dr. Moewardi General Hospital. Surakarta. Methods: A cross-sectional observational study was conducted on 30 patients diagnosed with scurvy at Dr. Moewardi General Hospital Surakarta during the 2020-2023 period. Demographic data, medical history, nutritional status, and severity of scurvy were collected. A radiological examination of the bone is performed to assess scurvy-related changes. Descriptive, comparative, and Spearman correlation statistical analyzes were used. Results: The majority of patients were men (66.7%) with a mean age of 45 years. A history of an unbalanced diet with low fruit and vegetable intake was found in the majority of patients (86.7%). Common symptoms include fatigue (86.7%), joint pain (73.3%), bleeding gums (60%), and skin bleeding (53.3%). The severity of scurvy varied, with 10 patients (33.3%) experiencing severe scurvy. Radiological examination shows significant changes in long bones, especially osteoporosis and thinning of the cortex, which is more obvious in patients with severe scurvy. Spearman correlation analysis showed a positive correlation between the severity of scurvy and the incidence of osteoporosis (rho = 0.495, p = 0.005) and cortical thinning (rho = 0.394, p = 0.031). Conclusion: Vitamin C hypovitaminosis plays a significant role in the development of scurvy and has a negative impact on bone health. Early screening and diagnosis of scurvy are important to prevent musculoskeletal complications. Nutritional education and dietary interventions to increase vitamin C intake need to be intensified, especially in high-risk groups.
Analysis of the Role of Vitamin C Hypovitaminosis in Scurvy on Bone Health: A Single Center Observational Study at Dr. Moewardi General Hospital, Surakarta, Indonesia Nefihancoro, Udi Heru; Rachmad Faisal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1066

Abstract

Background: Scurvy, vitamin C deficiency, is a rare condition but remains relevant in Indonesia. This study aims to analyze the role of vitamin C hypovitaminosis in the development of scurvy and its impact on bone health through an observational study at Dr. Moewardi General Hospital. Surakarta. Methods: A cross-sectional observational study was conducted on 30 patients diagnosed with scurvy at Dr. Moewardi General Hospital Surakarta during the 2020-2023 period. Demographic data, medical history, nutritional status, and severity of scurvy were collected. A radiological examination of the bone is performed to assess scurvy-related changes. Descriptive, comparative, and Spearman correlation statistical analyzes were used. Results: The majority of patients were men (66.7%) with a mean age of 45 years. A history of an unbalanced diet with low fruit and vegetable intake was found in the majority of patients (86.7%). Common symptoms include fatigue (86.7%), joint pain (73.3%), bleeding gums (60%), and skin bleeding (53.3%). The severity of scurvy varied, with 10 patients (33.3%) experiencing severe scurvy. Radiological examination shows significant changes in long bones, especially osteoporosis and thinning of the cortex, which is more obvious in patients with severe scurvy. Spearman correlation analysis showed a positive correlation between the severity of scurvy and the incidence of osteoporosis (rho = 0.495, p = 0.005) and cortical thinning (rho = 0.394, p = 0.031). Conclusion: Vitamin C hypovitaminosis plays a significant role in the development of scurvy and has a negative impact on bone health. Early screening and diagnosis of scurvy are important to prevent musculoskeletal complications. Nutritional education and dietary interventions to increase vitamin C intake need to be intensified, especially in high-risk groups.
Liquid Nitrogen-Recycled Autograft Augmented with a Non-Vascularized Fibular Strut for Refractory Pediatric Osteosarcoma: A Case Report of the Cryo-Immunological Reconstruction Mujjadid Idulhaq; Khrisna Purwa Satyaksa; Rachmad Faisal
Archives of The Medicine and Case Reports Vol. 6 No. 4 (2025): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v6i4.827

Abstract

Reconstruction of large segmental bone defects following limb salvage surgery for osteosarcoma presents a significant challenge in pediatric populations, particularly in resource-limited settings where expandable endoprostheses are inaccessible. This study evaluates the efficacy of a biological reconstruction technique using Liquid Nitrogen-treated recycled autograft augmented with a fibular strut, known as the Modified Capanna Technique. We present the case of an 8-year-old female with Enneking Stage IIB high-grade osteoblastic osteosarcoma of the distal femur. The patient exhibited a refractory response (Huvos Grade II) to a neoadjuvant non-methotrexate chemotherapy regimen. Wide resection was performed, followed by a specific cryo-protocol: the tumor-bearing bone was frozen in Liquid Nitrogen (−196°C) for 20 minutes, thawed physiologically, augmented with an intramedullary non-vascularized fibular strut, and stabilized with a locking compression plate. At 12 months postoperative, the patient achieved solid radiographic union with a Radiographic Union Scale for Tibial fractures score of 11/12. No local recurrence or distant metastasis was detected. The Musculoskeletal Tumor Society score improved from 10% pre-operatively to 80% post-operatively, reflecting independent ambulation. A comparative analysis revealed that the procedure cost was approximately 12% of a standard imported megaprosthesis. In conclusion, the liquid nitrogen-recycled autograft, when mechanically augmented, offers a theoretically sound and cost-effective limb salvage solution. It provides immediate anatomical restoration and potential cryo-immunological benefits, making it a viable alternative for refractory cases in developing healthcare systems.
Co-Authors Khrisna Purwa Satyaksa Mujjadid Idulhaq Nefihancoro, Udi Heru