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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Ophthalmologica Indonesiana
Pandjaitan, Hadwer Wicaksono
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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CORRELATION OF CENTRAL CORNEAL THICKNESS TO ACTUAL INTRAOCULAR PRESSURE IN MYOPIA PATIENTS Pandjaitan, Hadwer Wicaksono; Ariesti, Andrini
Majalah Oftalmologi Indonesia Vol 51 No 1 (2025): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v51i1.101669

Abstract

Background : Central Corneal Thickness (CCT) is promote in the diagnosis and management of glaucoma, especially in myopic patients. Understanding the correlation between CCT and IOP (Intraocular Pressure) aids in glaucoma detection and control. The objective of this study is to determine the correlation between CCT and actual IOP in myopic patients. Methods : This research is an observational study with ethical committee approval, involving medical students from the Faculty of Medicine at Andalas University undergoing clinical clerkships at Dr. M Djamil Padang General Hospital. They were grouped into emmetropia, mild myopia, and moderate myopia. Data included visual acuity measurements, autorefraction, CCT measurements using OCT, and IOP with CCT correction. Samples with eye abnormalities, systemic conditions, myopia > 6D, a history of eye surgery, contact lens wear, and IOP > 21 mmHg were excluded. All data were analyzed statistically. Results : The study involved 78 eyes from 78 individuals, consisting of 26 eyes per group. The actual CCT and IOP values in mild myopia, moderate myopia and emmetropia are 506.31 ± 11,263 μm with 15.81 ± 1,234 mmHg, 533.96 ± 21,342 μm with 16.12 ± 1,336 mmHg, and 487.81 ± 28,272 μm with 15.35 ± 1.056 mmHg. There was a strong positive correlation between CCT and IOP (r=0.737, p=0.000), as well as a moderate negative correlation between CCT and actual IOP (r=-0.492, p=0.000). Conclusion : This research reveals a negative correlation between CCT and actual IOP in myopic patients, highlighting the importance of glaucoma screening for myopic patients due to their thinner corneas.
Risk Factors Associated with Intraocular Pressure and the Correlation of Central Corneal Thickness to Actual Intraocular Pressure in Myopia Patients Pandjaitan, Hadwer Wicaksono; Andrini Ariesti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1112

Abstract

Background: Myopia, a prevalent refractive error, is associated with an increased risk of glaucoma, a leading cause of irreversible blindness. Central corneal thickness (CCT) is a key factor in glaucoma assessment, as thinner corneas can lead to underestimation of intraocular pressure (IOP). This study aimed to investigate the correlation between CCT and actual IOP in myopic patients, considering various risk factors that may influence IOP. Methods: This cross-sectional study included myopic patients aged 20-25 years. Participants underwent comprehensive ophthalmic examinations, including visual acuity assessment, autorefraction, CCT measurement using optical coherence tomography (OCT), and Goldmann applanation tonometry for IOP measurement. IOP values were corrected for CCT. Statistical analysis was performed using ANOVA, Pearson correlation tests, and multivariate regression analysis to identify independent risk factors for elevated IOP. Results: A total of 78 eyes from 78 participants were analyzed. The mean CCT was significantly thinner in moderate myopia compared to mild myopia and emmetropia (p = 0.000). While IOP was lower in moderate myopia, the actual IOP, after CCT correction, was not significantly different among the groups (p = 0.078). A strong positive correlation was found between CCT and IOP (r = 0.737, p = 0.000), and a moderate negative correlation was observed between CCT and actual IOP (r = -0.492, p = 0.000). Multivariate regression analysis identified axial length (p = 0.021) and family history of glaucoma (p = 0.038) as independent risk factors for elevated IOP. Conclusion: This study highlights the importance of CCT assessment in myopic patients, as thinner corneas can mask elevated IOP. Regular eye examinations, including CCT and IOP measurements, are crucial for early detection and management of glaucoma in this high-risk population. Axial length and family history of glaucoma were identified as independent risk factors for elevated IOP, emphasizing the need for comprehensive risk assessment in myopic individuals.
Risk Factors Associated with Intraocular Pressure and the Correlation of Central Corneal Thickness to Actual Intraocular Pressure in Myopia Patients Pandjaitan, Hadwer Wicaksono; Andrini Ariesti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1112

Abstract

Background: Myopia, a prevalent refractive error, is associated with an increased risk of glaucoma, a leading cause of irreversible blindness. Central corneal thickness (CCT) is a key factor in glaucoma assessment, as thinner corneas can lead to underestimation of intraocular pressure (IOP). This study aimed to investigate the correlation between CCT and actual IOP in myopic patients, considering various risk factors that may influence IOP. Methods: This cross-sectional study included myopic patients aged 20-25 years. Participants underwent comprehensive ophthalmic examinations, including visual acuity assessment, autorefraction, CCT measurement using optical coherence tomography (OCT), and Goldmann applanation tonometry for IOP measurement. IOP values were corrected for CCT. Statistical analysis was performed using ANOVA, Pearson correlation tests, and multivariate regression analysis to identify independent risk factors for elevated IOP. Results: A total of 78 eyes from 78 participants were analyzed. The mean CCT was significantly thinner in moderate myopia compared to mild myopia and emmetropia (p = 0.000). While IOP was lower in moderate myopia, the actual IOP, after CCT correction, was not significantly different among the groups (p = 0.078). A strong positive correlation was found between CCT and IOP (r = 0.737, p = 0.000), and a moderate negative correlation was observed between CCT and actual IOP (r = -0.492, p = 0.000). Multivariate regression analysis identified axial length (p = 0.021) and family history of glaucoma (p = 0.038) as independent risk factors for elevated IOP. Conclusion: This study highlights the importance of CCT assessment in myopic patients, as thinner corneas can mask elevated IOP. Regular eye examinations, including CCT and IOP measurements, are crucial for early detection and management of glaucoma in this high-risk population. Axial length and family history of glaucoma were identified as independent risk factors for elevated IOP, emphasizing the need for comprehensive risk assessment in myopic individuals.
Co-Authors Andrini Ariesti Ariesti, Andrini