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All Journal Indonesian Journal of Urology
Satria, Hikmat
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Health Professions Medicine & Pharmacology Public Health

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THE ROLE OF DOCETAXEL AS FIRST-LINE CHEMOTHERAPY ON PSA LEVEL AND QOL IN CRPC PATIENTS Seputra, Kurnia Penta; Nurhadi, Pradana; Satria, Hikmat
Indonesian Journal of Urology Vol 31 No 2 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i2.853

Abstract

Objective: Prostate cancer is the second most common cancer in men and the fifth leading cause of death worldwide. 10-20% of cases can progress to a more aggressive stage called castration-resistant prostate cancer (CRPC) with a higher death rate. Clinical guidelines recommend docetaxel as first-line chemotherapy and evaluated using the PSA test. This study aims to investigate the effect of docetaxel chemotherapy on PSA levels in CRPC. Material & Methods: A retrospective study was conducted from January 2016 until August 2022 according to the medical records database Saiful Anwar Hospital. There were 16 patients who met the inclusion criteria, including male patients with a diagnosis of CRPC who received castration therapy and found an increase in PSA 3 times of nadir or found 2 or more bone metastatic lesions or soft tissue lesions > 2 cm, received 6 series of docetaxel chemotherapy, and have a PSA data was performed before and after chemotherapy. Statistical analysis was performed using a differential T-test. Results: The results, obtained were significantly different (p<0.05) on the average PSA (log) pre-post chemotherapy, visual analog scale (VAS), and quality of life, and not significantly different on BMI pre-post chemotherapy. Conclusion: 6 cycles of docetaxel chemotherapy resulted in a decrease in PSA levels of CRPC significantly. It showed an excellent response to docetaxel chemotherapy in managing CRPC patients. Limitations of this study were specifically the retrospective cohort study model and the ability to reduce PSA levels in assessing the prognosis of CRPC. Keywords: Castration-resistant prostate cancer, chemotherapy, docetaxel, prostate-specific antigen.
THE EFFECT OF HIGH-INTENSITY FOCUSED ELECTROMAGNETIC (HIFEM) THERAPY ON PATIENTS WITH URGE URINARY INCONTINENCE Daryanto, Besut; Nur Budaya, Taufiq; Satria, Hikmat
Indonesian Journal of Urology Vol 33 No 1 (2026)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v33i1.1139

Abstract

Objective: This study aims to determine the effect of HIFEM on OABSS and pad usage through the Voiding Diary. Material & Methods: An experimental study with pre and post-test. Patients will be given a questionnaire before and after undergoing HIFEM therapy for six sessions, and be followed for one month. Data analysis was carried out using SPSS software. Paired T-test was used for data with normal distribution, while the Wilcoxon Non-parametric test was used for data which is not normally distributed. Data are considered statistically significant if the p-value <0.05. Results: Twenty-eight patients completed the study. After six HIFEM sessions, the mean OABSS significantly decreased from 12.89 ± 1.03 to 11.61 ± 1.59 (p < 0.001), and pad usage reduced from 8.39 ± 1.20 to 2.82 ± 1.56 (p < 0.001). Conclusion: Six sessions of HIFEM therapy were associated with a decrease in OABSS and pad use in patients with urinary incontinence. But OABSS did not significantly reduce in patient with DM and HT. Keywords: HIFEM, urinary incontinence, OABSS.
Co-Authors Kurnia Penta Seputra Nur Budaya, Taufiq Nurhadi, Pradana