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All Journal Indonesian Journal of Urology Journal of Biomedicine and Translational Research Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Biomolecular and Health Science Journal Indian Journal of Forensic Medicine & Toxicology
Kurnia Penta Seputra
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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IPP AS PREDICTIVE FACTOR FOR ACUTE URINARY RETENTION IN BPH PATIENTS Budaya, Taufiq Nur; Purnomo, Basuki B.; Daryanto, Besut; Seputra, Kurnia Penta; Satyagraha, Paksi
Indonesian Journal of Urology Vol 21 No 1 (2014)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v21i1.26

Abstract

Objective: To demonstrate usefulness of Intra Prostatic Protrusion (IPP) as Predictive Factor for Acute Urinary Retention (AUR) in Benign Prostate Hyperplasia (BPH) Patients. Material & methods: Cross sectional retrospective study of case records from January to July 2012 of BPH patients at Saiful Anwar General Hospital (SAGH) Malang was carried out. The data were collected from the Medical Record Division in SAGH Malang. We noted age, prostate volume, IPP, IPSS and urinary retention status. The patients were classified by IPP degree < 5 mm (group A), 5-10 mm (group B), 10 -15mm (group C), > 15mm (group D) and we compared all parameters that we noticed. Results: Eighty patients, mean age was 66.32 years were enrolled. Transabdominal ultrasound determined the mean IPP was 13.5 mm, and prostatic volume 95 cc. IPP values were distributed as follows: group A 10 (12.5%), group B 25 (31.25%), group C 24 (30%), group D 21 (26.25%), with AUR incidence in group A 20%, group B 36%, group C 79%, and group D 81%. The IPP showed a significant correlation with urinary retention (r = 0.8, p < 0.05, OR = 15) and IPSS (r = 0.6, p < 0.05). Conclusion: IPP can be used as predictive factor for the incidence of acute urinary retention in BPH Patients.Keywords: Intra Prostatic Protrusion, Acute Urinary Retention, Benign Prostate Hyperplasia.
PERBEDAAN IPSS, Q MAX, DAN VOLUME PROSTAT PADA PEMBERIAN KOMBINASI INHIBITOR 5α-REDUKTASE (DUTASTERIDE) DAN ANTI ESTROGEN (TAMOXIFEN) PADA PASIEN BPH YANG MENGALAMI LUTS TANPA KOMPLIKASI Seputra, Kurnia Penta; Soetojo, Soetojo; Soebadi, Doddy M
Indonesian Journal of Urology Vol 15 No 2 (2008)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v15i2.351

Abstract

Objective: To compare the IPSS, Q max, and volume of the prostate pre and post treatment of 5α-reductase inhibitor and tamoxyfen in patients with BPH. Material and Methods: We collected 40 patients who had been diagnosed as BPH without urine retention. They were classified in to 4 groups, each group contained of 10 patients who were given tamoxifen, dutasteride, combination tamoxyfen with dutasteride, or placebo. We recorded IPSS, uroflow, and volume of the prostate before and after 3 months of medication. Data were analyzed by the SPSS 12 program. Results: Q max (7,75 + 3,5538 to 9,15 + 2,9448) and IPSS (z score –1,633) after treatment with tamoxyfen (p > 0,05) was not improved. We found significant decrease of the prostate volume (40,124 + 7,9129 to 36,323 + 8,2573) after treatment with tamoxifen (p < 0,05). There is significant improvement of Q max (9,55 + 3,2793 to 15,12 + 4,3522), IPSS (z score –2,887), and significant decrease of the prostate volume (30,93 + 9,0031 to 24,506 + 7,3267) after treatment with dutasteride (p < 0,05). There was also significant improvement of Q max (6,55 + 2,5435 to 8,86 + 4,4475), IPSS (z score –2,449), and decrease of prostate volume (31,403 + 9,0031 to 26,78 + 7,3267) after treatment with the combination dutasteride and tamoxifen (p < 0,05). None of those parameters were improved in placebo group. Conclusion: Q max and IPSS improve significantly in the dutasteride and the combination group. There was a significant decrease of the prostate volume in all groups except the placebo group.
PROFIL KLINIKOPATOLOGI ADENOKARSINOMA PROSTAT DI RSUD DR. SAIFUL ANWAR MALANG PERIODE TAHUN 2015 - 2019: SEBUAH PENELITIAN RETROSPEKTIF Ulfaningtyas, Kiki; Norahmawati, Eviana; Anita, Kenty Wantri; Angelina, Aina; Seputra, Kurnia Penta
Majalah Kesehatan FKUB Vol 8, No 2 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.02.4

Abstract

Kanker prostat adalah penyebab keganasan ke-5 pada pria di Indonesia. Atas dasar ini, dilakukan penelitian yang bertujuan  untuk  mengetahui  profil klinikopatologi pasien yang terdiagnosis adenokarsinoma  prostat  di Laboratorium Patologi Anatomi RSUD Dr. Saiful Anwar (RSSA) Malang. Penelitian ini dilakukan secara deskriptif retrospektif dengan data diperoleh dari rekam medis pada Laboratorium Patologi Anatomi RSUD Dr. Saiful Anwar Malang tahun 2015-2019. Kriteria inklusi sampel penelitian adalah semua kasus yang terdiagnosis adenokarsinoma prostat secara histopatologis. Sedangkan spesimen dengan kecurigaan adenokarsinoma prostat yang masih harus dilakukan pemeriksaaan imunohistokimia dikeluarkan dari penelitian. Penelitian menunjukkan penderita adenokarsinoma prostat di Laboratorium Patologi Anatomi RSSA Malang periode tahun 2015-2019 sebanyak 84 (7,58%) kasus, memiliki rentang umur 52-88 tahun, dengan rata-rata usia 68 tahun.  Paling banyak terdiagnosis dari spesimen kerokan, sebanyak 48 (57,14%) kasus.  Sebagian besar diagnosis klinis sesuai dengan hasil pemeriksaan histopatologinya yakni 55 (65,48%) kasus. Derajat diferensiasi yang terbanyak adalah poorly differentiated sebanyak 46 (54,76%) kasus dan prognostic Gleason group grade terbanyak didapatkan grade 4 sebanyak 25 (29,76%) kasus. Dapat disimpulkan kasus adenokarsinoma prostat  rata-rata terjadi pada usia 68 tahun, paling banyak didiagnosis pada bahan kerokan. Sebagian besar kasus memiliki kesesuaian antara diagnosis klinis dan diagnosis histopatologi.  Kasus yang didiagnosis umumnya termasuk dalam kategori poorly differentiated dan prognostic Gleason group grade  4.
The Characteristic of Toddlers Reproductive Health in Posyandu Matahari, Blimbing, Malang, East Java, Indonesia Kurnia Penta Seputra; Besut Daryanto; Zen A Prasetyo; Johanes Dwi Meiyanto; Hamdan Yuwafi Naim
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15838

Abstract

Background & Objective: The screening of reproductive health plays an essential role of early detectionof reproductive health disorder. There was a study which suggested that there was at least one congenitaldisorder every 100 live births. The Congenital reproductive disorder are mostly found in type of hypospadias,enlarged clitoris, micropenis, fusion of labia majora, and genital ambiguity. Data collected in Saiful AnwarGeneral Hospital revealed that period of 2012-2017 there were 109 hypospadias cases, 64 undescendedtesticle cases, and 80 cases of testicular torsion. However, for the Disorders of Sex Development cases, therewere found 12 cases from period of 2015-2017, with mean age was school age (8-14 years old). Unfortunately,there was no data of congenital reproductive disorder in toddlers, thus we conducted screening of toddlersreproductive health in PosyanduMatahari which located in Malang, East Java, Indonesia in order to find outthe number of incidence of toddlers congenital reproductive disorder and held the early detection.Materials & Methods: This is observational descriptive study. Screening was held in PosyanduMatahariwhich located in GedungSerbagunaRw. 14, Bunulrejo, Jodipan, Blimbing, Malang, in October 27, 2018. Itused method of physical examination (age, weight, height, external genital examination), and if it was foundsuspicious of disease or disorder of toddler congential reproductive health, thus it would be given referral toappropriate health careResults: This screening event involved 46 toddlers (1-5 years old). From 46 toddlers, there were 14 toddlers(30.43%), 10 toddlers suffered from Phimosis (21.74%), 1 toddler with Hydrocele (2.17%), dan 3 toddlerssuffered from UDT (6.52), who were referred to urology clinic in Saiful Anwar General Hospital to undergofurther examination and treatment.Conclusion:The incidence of toddlers reproductive disorder of this event was 30,43%, showed that thisage group (1-5 years old) had significant amount of congenital reproductive disorder and screening playedimportant role for early detection and improving parental knowledge to prevent the delay of treatment forreproductive disorder.
The Potential of Cammelia sinensis (Tea Leaves) Active Compound as Alternative Therapy on castrate-resistant prostate cancer (CRPC) with Androgen Receptor Inhibition: In Silico Study Mega Memory Rahasa Putra; Kurnia Penta Seputra
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.32147

Abstract

Introduction: Prostate cancer is a leading global cause of increased mortality and morbidity in men which can be complicated by castrate-resistant prostate cancer (CRPC). Pharmacological therapy by inhibiting the androgen receptor (AR) can inhibit prostate cancer progression. Tea leaves (Camellia sinensis) are believed to inhibit the prostate cancer progression but the mechanism is still unknown. Therefore, research on the mechanism by in silico study is needed with the AR as target protein.Methods: The effectivity of tea leaves’ active compound to inhibit androgen receptor was evaluated by docking server with abiraterone acetate as a control. The tea leaves' active compounds consist of catechin, epicatechin, epigallocatechin gallate, epigallocatechin, gallate epicatechin, gallocatechin gallate, and gallocatechinResults: The result showed that epicatechin, epigallocatechin, and gallocatechin have lower free binding energy (ΔG) and high amino acid residue similarity on AR compared with abiraterone acetate. But, it has lower surface interaction compared with abiraterone acetate. Conclusion: Epicatechin, epigallocatechin, and gallocatechin are predicted to have potential as alternative therapy in CRPC with AR Inhibition.
THE ROLE OF DOCETAXEL AS FIRST-LINE CHEMOTHERAPY ON PSA LEVEL AND QOL IN CRPC PATIENTS Seputra, Kurnia Penta; Nurhadi, Pradana; Satria, Hikmat
Indonesian Journal of Urology Vol 31 No 2 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i2.853

Abstract

Objective: Prostate cancer is the second most common cancer in men and the fifth leading cause of death worldwide. 10-20% of cases can progress to a more aggressive stage called castration-resistant prostate cancer (CRPC) with a higher death rate. Clinical guidelines recommend docetaxel as first-line chemotherapy and evaluated using the PSA test. This study aims to investigate the effect of docetaxel chemotherapy on PSA levels in CRPC. Material & Methods: A retrospective study was conducted from January 2016 until August 2022 according to the medical records database Saiful Anwar Hospital. There were 16 patients who met the inclusion criteria, including male patients with a diagnosis of CRPC who received castration therapy and found an increase in PSA 3 times of nadir or found 2 or more bone metastatic lesions or soft tissue lesions > 2 cm, received 6 series of docetaxel chemotherapy, and have a PSA data was performed before and after chemotherapy. Statistical analysis was performed using a differential T-test. Results: The results, obtained were significantly different (p<0.05) on the average PSA (log) pre-post chemotherapy, visual analog scale (VAS), and quality of life, and not significantly different on BMI pre-post chemotherapy. Conclusion: 6 cycles of docetaxel chemotherapy resulted in a decrease in PSA levels of CRPC significantly. It showed an excellent response to docetaxel chemotherapy in managing CRPC patients. Limitations of this study were specifically the retrospective cohort study model and the ability to reduce PSA levels in assessing the prognosis of CRPC. Keywords: Castration-resistant prostate cancer, chemotherapy, docetaxel, prostate-specific antigen.
EXPERIENCE OF TESTICULAR CANCER PATIENT LONG TERM FOLLOW-UP IN TERTIARY REFERRAL HOSPITAL Nugroho, Prasetyo; Seputra, Kurnia Penta; Medianto
Indonesian Journal of Urology Vol 31 No 1 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i1.868

Abstract

Objective: This study aims to determine the survivability testicular cancer patients at a tertiary hospital in Malang, Indonesia. Material & Methods: This is study conducted from January 2021 to January 2022 at Saiful Anwar General Hospital in Malang, East Java. Involving 32 testicular cancer patients. Data was obtained through medical record January 2017 – January 2022. Analysis was carried out to determine the survivability of the patient. Results: The results showed that the proportion of 1 to 5 year survival rate in testicular cancer patients was 96% and 21%. Kaplan Meier test showed significant difference of patient survival in the radiation therapy exposure (p=0.021), Karnofsky score (p=0.010), tumour type (p=0.019), and response of chemotherapy (p=0.015). Conclusion: The survival rate of testicular cancer patients are strongly influenced by the karnofsky score, radiation therapy exposure, tumour type, and chemotherapy response. Therefore early diagnosis and treatment plays an important role in improving survival rate of the patients. Keywords: Testicular cancer, survival rate, seminoma, non seminoma.
SUCCESSFUL TRANSURETHRAL RESECTION OF ANTERIOR URETHRAL VALVE IN CHILDREN : A CASE REPORT Akbar, Fariz Kemal; Seputra, Kurnia Penta; Nurhadi, Pradana
Indonesian Journal of Urology Vol 31 No 1 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i1.933

Abstract

Objective: This case report will present transurethral resection of double anterior urethral valves in tertiary hospital. Case(s) Presentation: A three-year-old boy who complained of a poor stream of urine and discomfort during micturition. From the radiological examination, the main finding was found on ultrasound (USG), with thickening of the bladder wall without upper tract abnormality. On panendoscopy, we found double anterior urethral valves at bulbar part and trabeculation in bladder. Discussion: The resection of the valves was performed and achieved an excellent result included normal stream of urine and there was no discomfort during micturition. Conclusion: Anterior Urethral Valve is a rare case that can be caused a lower urinary tract obstruction. A good understanding of AUV’s radiological and endoscopic anatomy is required to differentiate it from other diseases, essential to prevent further injury, and also to decide for appropriate management. Keywords: Anterior Urethral Valve, Congenital Anomaly, Urinary Obstruction
Revealing the Potency of Camelia sinensis and Serenoa repens as Purinoreceptor Inhibitor for Benign Prostatic Hyperplasia Treatment through in Silico Study Putra, Mega Memory Rahasa; Seputra, Kurnia Penta
Journal of Biomedicine and Translational Research Vol 10, No 2 (2024): August 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i2.21211

Abstract

Background: Benign prostatic hyperplasia (BPH) is the most common prostate disease in elderly men that leads to a significant deterioration in patients' quality of life (QoL). Pharmacological therapy of 5-alpha reductase inhibitor and alpha adrenoreceptors blocker often causes several side effects that decrease the QoL, so it is necessary to develop a new treatment for BPH. Purinoreceptor is a novel receptor that can inhibit electrically evoked nerve-mediated contractions in the prostate. Tea leaves (Camellia sinensis) and Saw palmetto (Serenoa repens) are herbs that have potential as alternative therapies for BPHObjective: to reveal the mechanism of Camellia sinensis and Serenoa repens through purinoreceptor and the other receptorsMethods: Structures of active compounds were extracted from PubChem and protein from PBD. The active compounds Camellia sinensis and Serenoa repens to the target protein purinoreceptors, 5-alpha-reductase, and alpha adrenoreceptors was evaluated in silico using a docking server with Finasteride dan Tamsolusin as a control. Molecular docking method using dockingserver application.Results: Epigallocatechin gallate only compound that has potency in blocking purinoceptors and 5-alpha-reductase. Capric acid, Caprylic acid, Lauric acid, Linoleic acid, and Myristic acid have the potential to bind to alpha adrenoreceptor ligands.Conclusion: Camellia sinensis have potential and effects as alternative therapies in benign prostatic hyperplasia on the target protein purinoreceptors, 5-alpha-reductase, and alpha adrenoreceptors. But, Serenoa repens have potential only through alpha adrenoreceptors.
SARM Rad140 Increases Osteoblasts, Muscle Fiber Size, Myonuclei, and Reduces Osteoclasts in Orchidectomized Wistar Rats Budaya, Taufiq Nur; Daryanto, Besut; Seputra, Kurnia Penta; Fabrianta, Dio Mafazi; Ekaputra, Aditya Airlangga; Dewi, RA Rose Khasana; Anita, Kenty Wantri; Dhani, Fauzan Kurniawan; Rofifa, Amira Fithri
Molecular and Cellular Biomedical Sciences Vol 9, No 1 (2025)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v9i1.536

Abstract

Background: Orchidectomy is a surgical androgen deprivation therapy (ADT) for prostate cancer patients to achieve castrate testosterone levels. Selective androgen receptor modulators (SARMs) are used to mitigate the adverse effects of ADT, including elevated risk of osteoporosis, and reduced skeletal muscle mass. Rad140 is a novel SARMs that has high affinity for the androgen receptors. This study was conducted to determine the effects of SARM Rad140 on the number of osteoblasts, osteoclasts, muscle fiber cross-sectional area (CSA), muscle size, and number of myonuclei in rats underwent orchidectomy.Materials and Methods: An experimental study was conducted using a randomized post-test only control group design. Following orchidectomy, SARM Rad140 was administered orally for six weeks at various doses. Osteoblasts, osteoclasts, muscle fiber CSA, muscle size, and number of myonuclei were measured. Quantitative analysis was performed using one-way ANOVA.Results: There were significant differences in the effects of SARM Rad140 at different doses on osteoblast and osteoclast cells. At higher doses, the osteoblast cell counts in rats tended to increase, while the osteoclast counts tended to decline. The treatment group also showed significant results in the CSA of the gastrocnemius muscle fibers, as well as in the number of myonuclei of the gastrocnemius muscle.Conclusion: SARM Rad140 significantly increased the number of osteoblasts, muscle fiber CSA, and gastrocnemius muscle myonuclei, while decreasing osteoclasts. SARM Rad140 is a promising therapy for osteoporosis and muscle weakening due to ADT.Keywords: SARM Rad140, orchidectomy, osteoblasts, osteoclasts, muscle fiber cross sectional area, myonuclei
Co-Authors Aina Angelina Akbar, Fariz Kemal Basuki B. Purnomo Dewi, Rose Khasana Dhani, Fauzan Kurniawan Doddy M Soebadi Ekaputra, Aditya Airlangga Eviana Norahmawati Fabrianta, Dio Mafazi Hamdan Yuwafi Naim Husein, Rahmat Johanes Dwi Meiyanto Kenty Wantri Anita, Kenty Wantri Medianto Mega Memory Rahasa Putra Nurhadi, Pradana Paksi Satyagraha Prabowo, Satria Adji Hady Prasetyo Nugroho Putra, Mega Memory Rahasa Rachmad Sarwo Bekti Rofifa, Amira Fithri Satria, Hikmat Soetojo Soetojo Taufiq Nur Budaya Ulfaningtyas, Kiki Zen A Prasetyo