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All Journal Indonesian Journal of Urology Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Global Health research
Purnomo, Athaya Febriantyo
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Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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FACTORS INFLUENCING POST-CIRCUMCISION WOUND HEALING Daryanto, Besut; Satyagraha, Paksi; Kustono, Andri; Dhani, Fauzan Kurniawan; Negara, Edvin Prawira; Purnomo, Athaya Febriantyo; Sholihah, Nikmatus; Hanggara, Dian Sukma
Indonesian Journal of Urology Vol 31 No 2 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i2.960

Abstract

Objective: This study aims to determine the effect of the penile gland and smegma smear, the expression of collagen and fibroblasts in the preputium, on post-circumcision wound healing. Material & Methods: A cross-sectional study conducted in Malang with samples obtained by purposive sampling on September 17, 2022. Inclusive criteria were uncircumcised males who agreed to be circumcised and had no contraindications to the procedure. Furthermore, the preputium obtained from the circumcision procedure was stained with Hematoxylin-Eosin (HE) and counted under an optical microscope. Post-circumcision evaluation was carried out seven days after the procedure. The data were analyzed using the regression method; p denotes the probability value or significance level, while the b score denotes the degree of influence. Results: There were total of 31 research samples that had a significant difference in the average age between the samples with post-circumcision complaints (11.25 ± 2.75) and those without complaints (8.5 ± 2.73) (p=0.05). The regression test found that bacterial culture, fibroblasts, and collagen had significant effects of 24%, 25%, and 24%, respectively. Conclusions: Skin elasticity decreases with age, as marked by increased fibroblasts and decreased collagen density. Fibroblast factors, collagen, and bacterial culture are significant in wound healing. Keywords: Circumcision, collagen, fibroblast, wound healing.
Efficacy and safety of rituximab in children with steroid- and calcineurin inhibitor-dependent nephrotic syndrome: a systematic review of randomized controlled trials Sharon, Sharon; Nadhifah, Nadhifah; Heriawan, Timotius Ivan; Rahmatika, Nadya; Zahara, Nadia Eva; Purnomo, Athaya Febriantyo; Lazarus, Gilbert
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.490-500

Abstract

Background Efficacy of rituximab in the management of idiopathic nephrotic syndrome in children is well-established, however there is limited evidence of its efficacy in children with steroid- and calcineurin inhibitor-dependent nephrotic syndrome (CNI-SDNS). Objective To investigate the efficacy and safety of rituximab in children with CNI-SDNS. Methods We conducted a comprehensive search for relevant RCTs in PubMed, Scopus, Cochrane Central Register of Controlled Trials, and Google Scholar. Eligible RCTs were included, assessed for risk of bias using the Revised Cochrane risk-of-bias tool for randomized trials, and summarized narratively. Results A total of five RCTs (299 children) were included in the review. Rituximab was effective in maintaining remission and preventing relapse in pediatric CNI-SDNS patients, in a manner potentially superior to conventional therapy. Furthermore, rituximab successfully resulted in a higher rate of steroid and CNI withdrawal, along with prolonged drug-free period. However, the benefits of rituximab in children with focal segmental glomerulosclerosis (FSGS) remains equivocal. The drug was generally well-tolerated, both in the short-term and long-term, with a low incidence of adverse events and infusion reactions, typically of mild and reversible nature. Conclusion Rituximab appears to be effective and safe in treating children with CNI-SDNS, offering potential benefits in reducing dependence on steroids and CNIs. Larger trials comparing the effectiveness of rituximab specifically between children with minimal change disease (MCD) and FSGS are warranted to further validate and strengthen our findings.
Polymorphic CAG and GGN repeats in Cryptorchidism patient risk: A meta-analytical study Lutfiana, Nurul Cholifah; Purnomo, Athaya Febriantyo; Ibrahimiyah, Nur Aisah
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.22603

Abstract

Genetic mutations in the androgen receptor (AR) gene have been identified as the cause of androgen insensitivity syndrome. These mutations are linked to inconsistent development of the Wolffian duct and may result in conditions such as micropenis, hypospadias, and cryptorchidism. The androgen receptor has two polymorphic sites located in exon 1, which consists of varying amounts of CAG and GGN repeats. These repetitions lead to the formation of polyglutamine and polyglycine stretches of varied lengths. Increased CAG repeats lead to a decrease in androgen receptor transcriptional activity, but the impact of GGN triplets is less well understood. This research examined the CAG and GGN repeat lengths in males who had a past medical record of cryptorchidism. Prospective and retrospective observational studies from PubMed, Science Direct, and Embase were systematically searched up to 15th November 2020. Primary outcomes were analyzed using a fixed or random effect model regarding its heterogeneity and continued with multilevel modeling of each polymorphism and ethnicity. CAG and GGN repeat polymorphism was found to be significantly different compared to control in contributing to cryptorchidism (CAG: 0.55 [CI 95%=0.19-0.91]; p-value=0.003 and GGN 0.90 [CI95%=0.65-1.15]; p value<0.000).  In conclusion, CAG and GGN repeat polymorphism have an essential role in the incidence of cryptorchidism.
Effectiveness of Deep Brain Stimulation (DBS) in the Anterior Thalamic Nucleus (ATN) for Drug-Resistant Epilepsy: A Comprehensive Literature Review Hidayat, Yoga Arif; Monika, Caroline; Rusli, Bryant Agustino; Ramadhan, Irfan Fadillah; Purnomo, Athaya Febriantyo
Indonesian Journal of Global Health Research Vol 6 No 5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i5.3274

Abstract

Epilepsy, a chronic neurological disorder characterized by recurrent seizures, significantly impacts the lives of millions worldwide. While antiepileptic drugs have become the standard of care for seizure control, a substantial portion of epilepsy patients, estimated at approximately one-third, continues to experience seizures despite trying multiple medications. Consequently, there is a pressing need to explore alternative and more effective treatment options. This study was conducted to review more deeply Deep Brain Stimulation (DBS) has emerged as a promising intervention for individuals with drug-resistant epilepsy. DBS entails the implantation of small electrodes into specific brain regions to provide controlled electrical stimulation, aiming to modulate abnormal neural activity associated with seizures. Among the targeted brain regions, the Anterior Thalamic Nucleus (ATN) has garnered substantial attention due to its potential to reduce seizure frequency in individuals for whom conventional therapies have proven inadequate. A literature search was conducted from journal articles using databases in the form of Pubmed, Medline, Google Scholar, Proquest, Embase, SAGE, and Web of Science. The search strategy involved using a set of keywords and their synonyms without any publication date restrictions. In this comprehensive review, the effectiveness of DBS in the ATN for drug-resistant epilepsy is critically examined. Notably, recent clinical trials have shown significant promise. For instance, the SANTE (Stimulation of Anterior Nucleus of Thalamus for Epilepsy) study demonstrated that, after three months, 110 drug-resistant epilepsy patients receiving DBS in the ATN experienced a remarkable 40% reduction in seizure frequency. Long-term follow-up revealed progressive improvements, with a subsequent 69% decrease in seizure frequency over five years. There is potential adverse events associated with DBS, including bledding, infections, paresthesia, moving disorder and psychiatric disorder. DBS is highly effective in reducing seizure frequency, controlling seizures, and improving the patient’s quality of life. DBS can also serve as a treatment option for various other neurological disorders. In the future it is expected to become more effective with advances in neuroscience, particularly neurointerventions, which allow more precise anatomical targeting. Monitoring possible side effects caused by DBS is critical to optimizing patient outcomes. In conclusion, this review underscores the potential of DBS in the ATN as an effective therapy for drug-resistant epilepsy. While significant progress has been made, further research is needed to refine treatment parameters, enhance patient selection, and evaluate long-term outcomes. DBS represents a beacon of hope for individuals whose lives are profoundly affected by drug-resistant epilepsy, offering the prospect of improved seizure control and enhanced quality of life.
Co-Authors Dhani, Fauzan Kurniawan Hanggara, Dian Sukma Heriawan, Timotius Ivan Hidayat, Yoga Arif Ibrahimiyah, Nur Aisah Kustono, Andri Lazarus, Gilbert Lutfiana, Nurul Cholifah Monika, Caroline Nadhifah, Nadhifah Negara, Edvin Prawira Nikmatus Sholihah Paksi Satyagraha Rahmatika, Nadya Ramadhan, Irfan Fadillah Rusli, Bryant Agustino Sharon, Sharon Zahara, Nadia Eva