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All Journal Indonesian Journal of Urology Journal of Anaesthesia and Pain
Faida, Nova Auliyatul
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Health Professions Medicine & Pharmacology Public Health

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ASSESSING CARDIOVASCULAR SAFETY OF TESTOSTERONE REPLACEMENT THERAPY FOR MALE HYPOGONADISM: A SYSTEMATIC REVIEW AND META-ANALYSIS Rachman, Manarul Iman Alfafa; Vilado, Irene Yasmina; Satriawan , Ilham; Lalchanzani , Jawaharlal Akbar; Faida, Nova Auliyatul; Permata , Angeline Asti Shiela; Nurhadi, Pradana; Daryanto, Besut
Indonesian Journal of Urology Vol 31 No 3 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i3.988

Abstract

Objective: This study aims to comprehensively assess TRT's cardiovascular safety in males with hypogonadism, providing valuable insights for treatment decisions. Material & Methods: Adhering to PRISMA guidelines, we registered our PROSPERO protocol and analyzed relevant English-language randomized clinical trials published from 2008 to 2023. Results: Among 1187 initial papers, 7 studies met inclusion criteria, with 6 in quantitative analysis and all 7 in qualitative assessment. Our findings indicate that TRT does not significantly increase the risk of cardiovascular events compared to placebo. Specifically, the analysis of major adverse cardiac events (MACE) yielded an OR of 0.90 (95% CI: 0.74, 1.10; I² = 26%; p = 0.25), while the evaluation of all cardiovascular adverse events revealed an OR of 1.37 (95% CI: 0.73, 2.55; I² = 75%; p = 0.001). Conclusion: This study offers reassurance for clinical decision-making by suggesting that TRT is not significantly associated with an elevated cardiovascular risk in hypogonadal men, addressing the ongoing debates on this issue. Keywords: Cardiovascular safety, hypogonadism, testosterone replacement therapy.
Comparison of General Anesthesia vs Spinal Anesthesia on Post Operative Pain After Hysterectomy - A Systematic Review and Meta-analysis Lalchanzani, Jawaharlal Akbar; Faida, Nova Auliyatul; Auzan, Asyrafly
Journal of Anaesthesia and Pain Vol. 7 No. 1 (2026): January
Publisher : Faculty of Medicine, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Background: Hysterectomy is among the most frequently performed major surgical procedures. General anesthesia (GA) remains the most commonly used technique. The selection between GA and spinal anesthesia (SA) can significantly impact patient outcomes, particularly in terms of pain control and the incidence of postoperative nausea and vomiting. This systematic review and meta-analysis aim to compare the effects of GA versus SA on duration of operation, pain intensity, post-operative analgesic consumption, and the incidence of nausea and vomiting in patients undergoing hysterectomy. Methods: This systematic review and meta-analysis were conducted to assess the duration of operation, pain intensity, postoperative analgesic consumption, and the incidence of nausea and vomiting in GA and SA in hysterectomy. The data was tested using random-effect models.   Result: Out of eight studies, a total of 1.054 patients were included. Our findings indicate that the intensity of postoperative pain in the GA group obtained a significantly higher Visual Analogue Scale (VAS) Score compared to the SA group (MD, 0.84; 95% CI, [0.11, 1.56]; p = 0.02, I² = 56%). However, no significant results were found on other outcomes including operative time (MD, 1.95; 95% CI, [-1.30, 5.19]; p = 0.24, I² = 10%), analgesic consumption (MD, -7.48; 95% CI, [-20.38, 5.43]; p = 0.26, I² = 96%) and nausea vomiting events (RR, 0.71; 95% CI, [0.48, 1.05]; p = 0.09, I² = 0%). Conclusion: SA showed significant reductions in pain scores compared with GA, suggesting potential benefits for pain relief. However, the choice of anesthesia should be guided by patient-specific factors, the complexity of the surgery, and clinical preferences.
Co-Authors Auzan, Asyrafly Lalchanzani , Jawaharlal Akbar Lalchanzani, Jawaharlal Akbar Nurhadi, Pradana Permata , Angeline Asti Shiela Rachman, Manarul Iman Alfafa Satriawan , Ilham Vilado, Irene Yasmina