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Journal : Heart Science Journal

Hemodialysis prophylaxis and renal replacement therapy in contrast associated acute kidney injury (CA-AKI): literature study Satwikajati, Sawitri; Novi Kurnianingsih
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.6

Abstract

Contrast associated acute kidney injury (CA-AKI) had been the main focus along the development of percutaneous invasive procedure. Contrast associated acute kidney injury (CA-AKI) increase risk of dead among hospitalized patient. The use of iodine based contrast along percutaneous procedure potentially induce contrast associated acute kidney injury (CA-AKI). Many potential hazardous effect may effect individual with CA-AKI such as myocardial re-infarction, stent thrombosis, dead, and major adverse cardiac event (MACE). Many strategies had been developed to prevent and treat CA-AKI such as risk stratification, hydration with normal saline, avoid nephrotoxic drug, use of statin, and N-acetilcystein but when all strategies failed, hemodialysis prophylaxis and renal replacement therapy had potential benefit in CA-AKI.
Hemodialysis prophylaxis and renal replacement therapy in contrast associated acute kidney injury (CA-AKI): literature study Satwikajati, Sawitri; Novi Kurnianingsih
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.6

Abstract

Contrast associated acute kidney injury (CA-AKI) had been the main focus along the development of percutaneous invasive procedure. Contrast associated acute kidney injury (CA-AKI) increase risk of dead among hospitalized patient. The use of iodine based contrast along percutaneous procedure potentially induce contrast associated acute kidney injury (CA-AKI). Many potential hazardous effect may effect individual with CA-AKI such as myocardial re-infarction, stent thrombosis, dead, and major adverse cardiac event (MACE). Many strategies had been developed to prevent and treat CA-AKI such as risk stratification, hydration with normal saline, avoid nephrotoxic drug, use of statin, and N-acetilcystein but when all strategies failed, hemodialysis prophylaxis and renal replacement therapy had potential benefit in CA-AKI.
Correlation Study of Cotinine and Monocyte Chemoattractant Protein-1 (MCP-1) with Carotid Intima-Media Thickness (cIMT) in Male Active Tobacco Smoke Satwikajati, Sawitri; Kurnianingsih, Novi; Tjahjono, Cholid Tri; Wihastuti, Titin Andri; Sargowo, Djanggan; Rizal, Ardian
Heart Science Journal Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.01.6

Abstract

Background : Tobacco smoke exposure induces intima-media thickness by reducing nitric oxide and increasing adhesive molecule activity, with circulating cotinine serving as a marker; we hypothesize a correlation between monocyte chemoattractant protein-1 (MCP-1) and carotid intima-media thickness (cIMT) in active male smokers. Method : We conducted an observational cross-sectional analytic study involving 125 male participants, with 62 being active tobacco smokers and 63 non-smokers. Data were presented as mean ± SD, and the correlation between variables was analyzed using Pearson correlation. Result : Cotinine and MCP-1 levels were significantly higher in the smoker population (p 0.000) compared to non-smokers. The incidence of positive cIMT findings was higher in the smoker group (5%) than in the non-smoker group (2%). In the active smoker population, cotinine (r 0.21; p 0.11) showed a positive but non-significant correlation with positive cIMT findings, while MCP-1 showed a negative correlation (r -0.19, p 0.14) with positive cIMT findings. Smoking duration (r 0.162; p 0.223) and the amount of tobacco smoke (r 0.003; p 0.982) demonstrated a positive correlation with cotinine. MCP-1 exhibited a non-significant positive correlation with smoking duration (r 0.122; p 0.345) and a non-significant negative correlation with the amount of tobacco smoke (r -0.002; p 0.989). Conclusion : Among active tobacco smokers, cotinine showed a positive but non-significant correlation with positive cIMT findings, while MCP-1 exhibited a non-significant negative correlation with positive cIMT findings.Â