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All Journal Paediatrica Indonesiana Jurnal Prima Medika Sains Jurnal Ners Jurnal Neuroanestesi Indonesia
Siahaan, Andre Marolop Pangihutan
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Childhood borderline lepromatous leprosy Susanto, Martin; Hutahaean, Grace Dumamawarni; Napitupulu, Tiopan; Siahaan, Andre Marolop Pangihutan
Paediatrica Indonesiana Vol. 64 No. 4 (2024): July 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.4.2024.356-62

Abstract

Leprosy (Morbus Hansen) is a chronic, severe infectious disease caused by the Mycobacterium leprae that mostly affects the skin, mucosa, eyes, and nerves. Despite the availability of effective treatment, leprosy has become a major public health problem in many developing countries.
Microplastic: Characteristics, exposure pathways, toxicity, and implication for human health Amrullah, Muhammad Khalaf; Putri, Alifa Nabilah Elma; Nababan, Windika Yosephin; Siahaan, Andre Marolop Pangihutan
Jurnal Prima Medika Sains Vol. 6 No. 1 (2024): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i1.4942

Abstract

Microplastics particles ranging from 1 µm to 5 mm, have gained attention for their omnipresence in marine environments and potential health risks. Initially recognized in the 1990s, microplastics are classified as primary (designed for microscopic dimensions) or secondary (resulting from degradation). Exposure pathways include ingestion, inhalation, and dermal contact, with sources ranging from food and beverages to personal care products. These particles possess unique properties, facilitating their interaction with organic contaminants and potential bioaccumulation in marine life. Their small size allows them to infiltrate ecosystems, raising concerns about their impacts on human health. Studies suggest associations between microplastic exposure and health issues such as inflammatory bowel disease and neurodevelopmental. Microplastics exhibit toxicity through mechanisms like oxidative stress induction and disruption of neurotransmitter levels. They have been detected in human tissues, including the brain, raising concerns about potential neurological impacts. To comprehend the effects on health over time, additional research is required, including biopersistence and tissue accumulation. Regulatory measures and consumer awareness initiatives are crucial to mitigate microplastic pollution and minimize health risks. Strategies to reduce plastic production, enhance recycling, and develop microplastic removal technologies are vital for protecting both human health and the environment. In summary, microplastics pose significant health risks due to their widespread presence and potential toxicity. Understanding their impacts and implementing effective mitigation strategies are essential for safeguarding human health and environmental integrity.
Levetiracetam as an Alternative to Phenytoin for Prophylactic Use in Post-Traumatic Seizures: a Literature Review Nagatri, Gabriela; Situmorang, Dicky Arjuna; Ramoti, Natanael; Siahaan, Andre Marolop Pangihutan; Indharty, Rr. Suzy; Tandean, Steven
Jurnal Neuroanestesi Indonesia Vol 13, No 3 (2024)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v13i3.622

Abstract

Traumatic brain injury (TBI) is a common concern for the causes of disability and mortality and it can cause post-traumatic seizure (PTS). Currently, Brain Trauma Foundation (BTF) recommends phenytoin (PHY) as early PTS prophylaxis for patients with severe TBI. The two most common drugs prescribed for PTS are levetiracetam (LEV) and PHY. However, PHY displays a wide array of disadvantages. LEV appears as a better alternative to PHY because of its easier administration, the absence of need for drug level monitoring, lower drug-drug interaction, and better side-effects profile. It is due to the linear elimination kinetics LEV had in comparison to PHY that have zero order pharmacokinetics. Theoretically, LEV is better than PHY. But according to prior studies, LEV and PHY have comparable efficacy at preventing PTS in the early stages. Furthermore, the current evidence is insufficient to definitely recommend LEV over PHY in terms of effectiveness and adverse effects. This study aimed to analyze levetiracetam as an alternative to phenytoin for prophylactic use in post-traumatic seizure.
The Effect of Intra-Arterial Heparin on Neurogenesis in Neurogenic Areas of the Adult Rat Brain: A Narrative Literature Review Based on Ki-67 and Doublecortin Expression Saleh, Mohammad Fauzy; Anggraini, Dwi Rita; Siahaan, Andre Marolop Pangihutan
Jurnal Ners Vol. 10 No. 3 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.57976

Abstract

Abstract Background: Adult neurogenesis—the continuous generation of new neurons in the subgranular zone (SGZ) of the hippocampal dentate gyrus and the subventricular zone (SVZ)—represents a fundamental process of neural plasticity with implications for cognition, memory, and recovery from neurological injury. Heparin, a widely employed anticoagulant, has emerged as a pharmacological agent with pleiotropic effects on the central nervous system, including modulation of growth factor signaling pathways critical to neurogenesis. Objective: This narrative literature review aims to critically synthesize current evidence on the effects of intra-arterial heparin administration on adult neurogenesis, with particular focus on Ki-67 (cellular proliferation) and Doublecortin (DCX; immature neuron migration) as immunohistochemical biomarkers. Methods: A comprehensive search of Scopus, PubMed, ScienceDirect, and Google Scholar databases was conducted using predefined search strings. Studies published between 2015 and 2025 were prioritized, supplemented by seminal foundational works. Fifteen primary articles met inclusion criteria. Results: Converging evidence indicates that heparin exerts neuroproliferative and neuroprotective effects through its interactions with fibroblast growth factor-2 (FGF-2), brain-derived neurotrophic factor (BDNF), and the Wnt/β-catenin and NF-κB signaling pathways. Intra-arterial administration potentiates these effects by restoring microvascular perfusion, thereby facilitating the survival of Ki-67+ progenitor cells and the maturation of DCX+ neuroblasts in neurogenic niches. Conclusion: Intra-arterial heparin demonstrates significant potential as a pro-neurogenic intervention in adult rodent models, supporting its translational investigation in clinical neuropathological conditions. Standardized biomarker protocols combining Ki-67 and DCX immunolabeling are recommended for future preclinical studies. Keywords: adult neurogenesis; heparin; Ki-67; Doublecortin (DCX); neural progenitor cells; subgranular zone; subventricular zone
Co-Authors Amrullah, Muhammad Khalaf Anggraini, Dwi Rita Hutahaean, Grace Dumamawarni Manurung, Paul Behring Nababan, Windika Yosephin Nagatri, Gabriela Napitupulu, Tiopan Putri, Alifa Nabilah Elma Ramoti, Natanael Saleh, Mohammad Fauzy Simarmata, Ardaniel Euprasia Situmorang, Dicky Arjuna Susanto, Martin Suzy Indharty Tandean, Steven