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All Journal Paediatrica Indonesiana Jurnal Prima Medika Sains Jurnal Neuroanestesi Indonesia
Siahaan, Andre Marolop Pangihutan
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Childhood borderline lepromatous leprosy Susanto, Martin; Hutahaean, Grace Dumamawarni; Napitupulu, Tiopan; Siahaan, Andre Marolop Pangihutan
Paediatrica Indonesiana Vol. 64 No. 4 (2024): July 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.4.2024.356-62

Abstract

Leprosy (Morbus Hansen) is a chronic, severe infectious disease caused by the Mycobacterium leprae that mostly affects the skin, mucosa, eyes, and nerves. Despite the availability of effective treatment, leprosy has become a major public health problem in many developing countries.
Microplastic: Characteristics, exposure pathways, toxicity, and implication for human health Amrullah, Muhammad Khalaf; Putri, Alifa Nabilah Elma; Nababan, Windika Yosephin; Siahaan, Andre Marolop Pangihutan
Jurnal Prima Medika Sains Vol. 6 No. 1 (2024): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i1.4942

Abstract

Microplastics particles ranging from 1 µm to 5 mm, have gained attention for their omnipresence in marine environments and potential health risks. Initially recognized in the 1990s, microplastics are classified as primary (designed for microscopic dimensions) or secondary (resulting from degradation). Exposure pathways include ingestion, inhalation, and dermal contact, with sources ranging from food and beverages to personal care products. These particles possess unique properties, facilitating their interaction with organic contaminants and potential bioaccumulation in marine life. Their small size allows them to infiltrate ecosystems, raising concerns about their impacts on human health. Studies suggest associations between microplastic exposure and health issues such as inflammatory bowel disease and neurodevelopmental. Microplastics exhibit toxicity through mechanisms like oxidative stress induction and disruption of neurotransmitter levels. They have been detected in human tissues, including the brain, raising concerns about potential neurological impacts. To comprehend the effects on health over time, additional research is required, including biopersistence and tissue accumulation. Regulatory measures and consumer awareness initiatives are crucial to mitigate microplastic pollution and minimize health risks. Strategies to reduce plastic production, enhance recycling, and develop microplastic removal technologies are vital for protecting both human health and the environment. In summary, microplastics pose significant health risks due to their widespread presence and potential toxicity. Understanding their impacts and implementing effective mitigation strategies are essential for safeguarding human health and environmental integrity.
Levetiracetam as an Alternative to Phenytoin for Prophylactic Use in Post-Traumatic Seizures: a Literature Review Nagatri, Gabriela; Situmorang, Dicky Arjuna; Ramoti, Natanael; Siahaan, Andre Marolop Pangihutan; Indharty, Rr. Suzy; Tandean, Steven
Jurnal Neuroanestesi Indonesia Vol 13, No 3 (2024)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v13i3.622

Abstract

Traumatic brain injury (TBI) is a common concern for the causes of disability and mortality and it can cause post-traumatic seizure (PTS). Currently, Brain Trauma Foundation (BTF) recommends phenytoin (PHY) as early PTS prophylaxis for patients with severe TBI. The two most common drugs prescribed for PTS are levetiracetam (LEV) and PHY. However, PHY displays a wide array of disadvantages. LEV appears as a better alternative to PHY because of its easier administration, the absence of need for drug level monitoring, lower drug-drug interaction, and better side-effects profile. It is due to the linear elimination kinetics LEV had in comparison to PHY that have zero order pharmacokinetics. Theoretically, LEV is better than PHY. But according to prior studies, LEV and PHY have comparable efficacy at preventing PTS in the early stages. Furthermore, the current evidence is insufficient to definitely recommend LEV over PHY in terms of effectiveness and adverse effects. This study aimed to analyze levetiracetam as an alternative to phenytoin for prophylactic use in post-traumatic seizure.
Co-Authors Amrullah, Muhammad Khalaf Hutahaean, Grace Dumamawarni Manurung, Paul Behring Nababan, Windika Yosephin Nagatri, Gabriela Napitupulu, Tiopan Putri, Alifa Nabilah Elma Ramoti, Natanael Simarmata, Ardaniel Euprasia Situmorang, Dicky Arjuna Susanto, Martin Suzy Indharty Tandean, Steven