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All Journal As-syifaa Jurnal Farmasi JOPS (Journal Of Pharmacy and Science)
Dewi, Evelyne Citra
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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EFEK ANALGETIK EKSTRAK AKUADES DAUN MELINJO (Gnetum gnemon L.) PADA MENCIT PUTIH (Mus musculus L.) JANTAN DENGAN METODE INDUKSI ASAM ASETAT 1% Dewi, Evelyne Citra; Sodik, Anwar; Khuluq, Husnul; Intiyani, Rafila
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1055

Abstract

Pain is an unpleasant sensory and emotional feeling, associated with tissue damage. Melinjo leaves (Gnetum gnemon L.) are a plant that is useful as a traditional medicine for reducing and treating diseases, one of which is pain. The use of traditional medicine has fewer side effects than chemical medicine. This study aims to determine the analgesic activity and best dose of melinjo leaf distilled water extract in male white mice induced by 1% acetic acid. This research is experimental research. The subjects of this research were 25 male white mice. Mice were divided into 5 treatment groups with each group consisting of 5 mice. The treatment groups consisted of negative control CMC-Na 1%, positive control, melinjo leaf aqueous extract group at doses of 50, 100, and 150 mg/kgBW. The pain inducer was given 1% acetic acid. Observations were made by observing the movements of mice to calculate the % of analgesic protection. The data that has been obtained is then tested using One Way Anova and Post Hoc LSD or Games-Howell statistical tests. The results obtained by melinjo leaf aqueous extract at a dose of 150 mg/kgBW had the best analgesic effect because it had the largest % protection, namely 66.89%, and provided a significant effect (p<0.05) in mice induced by 1% acetic acid. Melinjo leaf aqueous extract at a dose of 150 mg/kgBW had the best analgesic effect on male white mice which was declared significant (p<0.05) and the mean difference value was greater.
Uji Efek Analgetik Ekstrak Metanol Daun Melinjo (Gnetum gnemon L.) pada Mencit Putih Jantan dengan Metode Induksi Asam Asetat 1% Dewi, Evelyne Citra; Khuluq, Muhammad Husnul; Sodik, Anwar
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.3908

Abstract

Nyeri merupakan perasaan sensoris serta emosional tidak menyenangkan, berhubungan dengan kerusakan jaringan. Daun melinjo salah satu tanaman yang bermanfaat sebagai obat tradisional untuk mengobati nyeri. Penggunaan obat tradisional efek sampingnya lebih rendah dibandingkan obat kimia. Penelitian ini bertujuan untuk mengetahui aktivitas analgetik dan dosis terbaik ekstrak metanol daun melinjo pada mencit yang diinduksi asam asetat 1%. Metode penelitian ini merupakan penelitian eksperimental dengan subjek penelitiannya mencit sebanyak 25 ekor yang dibagi 5 kelompok perlakuan dengan masing-masing kelompok terdiri 5 ekor mencit. Kelompok perlakuan terdiri kontrol negatif CMC-Na 1%, kontrol positif ponstan, kelompok ekstrak metanol daun melinjo dosis 50, 100, 150 mg/kgBB, penginduksi nyeri diberikan asam asetat 1%. Pengamatan dilakukan dengan mengamati geliat mencit untuk dihitung % proteksinya. Data kemudian diuji statistik One Way Anova dan Post-Hoc LSD atau Games-Howell. Hasil ekstrak metanol daun melinjo dengan dosis 150 mg/kgBB memiliki efek analgetik paling baik karena memiliki % proteksi 78,04%, serta memberikan efek yang signifikan pada mencit yang diiinduksi asam asetat 1%. Ekstrak metanol daun melinjo memiliki efek analgetik terbaik pada mencit secara signifikan (p<0,05) dan nilai mean differencenya lebih besar.
Co-Authors Anwar Sodik, Anwar Intiyani, Rafila Khuluq, Husnul Khuluq, Muhammad Husnul