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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Sehat Indonesia (JUSINDO) Journal of International Surgery and Clinical Medicine
Darmi, Noer Faisal
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Breastfeeding significant correlated with decreasing of breast cancer risk Muharram, Girry Gustianugraha; Darmi, Noer Faisal; Razi, Fachrul
Journal of International Surgery and Clinical Medicine Vol. 3 No. 2 (2023): (Available online: December 2023)
Publisher : Surgical Residency Program Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jiscm.v3i2.45

Abstract

Background: Extensive literature has established a strong correlation between breastfeeding and a decreased susceptibility to breast cancer. The objective of this study was to examine the breastfeeding status of moms diagnosed with breast cancer. Methods: This study employs a descriptive-analytical approach with a cross-sectional design. The study comprised adult female patients (aged 20-60) who were diagnosed with Breast Cancer, irrespective of the specific kind of cancer confirmed by anatomical pathological investigation. Only non-smokers were considered for analysis. The study excluded patients who had a history of malignancy and those with a family history of cancer. A bivariate analysis was performed to evaluate the study hypothesis. The analysis was conducted utilizing the Chi-Square and unpaired T-test statistical methods using SPSS software. A p-value less than 0.05 is deemed statistically significant. Result: This research encompassed a total of 45 individuals diagnosed with breast cancer. The majority of individuals diagnosed with breast cancer (55.6% of the total) did not engage in exclusive breastfeeding. Similarly, individuals without a breast cancer diagnosis also tended to refrain from exclusive nursing (24.4%). The association between the two variables is statistically significant, as indicated by a p-value of 0.000. The average length of nursing in individuals diagnosed with breast cancer was 2.04 ± 1.81, but in those without breast cancer, it was 10.10 ± 9.01. The statistical tests indicate a substantial association between the two variables, as evidenced by a p-value of 0.000. Conclusion: A notable correlation exists between breastfeeding and a diminished likelihood of developing breast cancer.
Breast Cancer Patients at Dr. Zainoel Abidin Hospital Banda Aceh Meildi, Maria; Arifki, Azwar; Razi, Fachrul; Darmi, Noer Faisal; Razi, Khalikul
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 2 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v7i2.295

Abstract

Breast cancer was the most common cancer-related death in women. Epidemiology reports the incidence to increase related to stage, histopathologic and subtype. Epidemiology reports in Aceh of breast cancer patients treated at Zainoel Abidin Banda Aceh Hospital are still limited. We want to report breast cancer patient profiles in Aceh. This study uses a quantitative descriptive approach by analyzing medical data of breast cancer patients recorded during 2021. The variables analyzed include age, age, location of cancer, histopathology type, grading and subtype of breast cancer performed. In this study, it was found that patients diagnosed with breast cancer were aged 36-50 years with images of 53 patients (37.86%) patients aged over 50 years and 14 (10%) patients aged under 36 years. The most common histopathology types were invasive ductal carcinoma 64%, and invasive lobular carcinoma 36%. Histopathology grading of breast cancer obtained the highest grade with grade III as many as 79 patients (56%). The most common subtype of breast cancer was triple negative. Breast cancer patients were most common at the age of 50 years old, histopathology was invasive ductal carcinoma, and the most common subtype of breast cancer was Triple Negative.
Pengaruh Periode Penggunaan Tamoxifen Terhadap Kejadian Endometriosis Pada Penderita Kanker Payudara Agreno, Marshal; Darmi, Noer Faisal; Ismy, Jufriady; Erdani, Ferry; Hidayat, Imam
Majalah Kedokteran Indonesia Vol 71 No 6 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.6-2021-447

Abstract

Introduction: Tamoxifen (selective estrogen receptor) is the standard hormonal therapy in women with breast cancer with positive estrogen receptor. The use of this regimen proved to reduce the incidence of relapse at local, collateral, or distant body area, and also decrease breast cancer mortality. One of the effects of tamoxifen is to induce endometrial proliferation, cause various abnormalities in endometrial tissue.Method: This study is an unpaired categorical comparative analytic study with a retrospective single cohort (internal comparison group) design. All breast cancer patients at dr. Zainoel Abidin Banda Aceh from 2017 - 2019 was involved in this research. Evaluation of the incidence of endometriosis was carried out based on the duration of tamoxifen using the Mann-Whitney U test. This study is an unpaired categorical comparative analytic study with a retrospective single cohort (internal comparison group) design. All breast cancer patients at dr. Zainoel Abidin Banda Aceh from 2017 - 2019 was involved in this research. Evaluation of the incidence of endometriosis was carried out based on the duration of tamoxifen using the Mann-Whitney U test.Result: A total of 114 patients (46.15%) out of a total of 247 breast cancer patients using tamoxifen reported experiencing endometriosis with a mean age of 49 years old. Most of the patients diagnosed with stage IIIB breast cancer of ductal cell carcinoma. A total of 111 people (97.37%) experienced endometriosis after taking tamoxifen for 30-36 months and the remaining 3 (2.63%) after 24-29 months. The mean duration of tamoxifen use associated with endometriosis was 34 months (p less than 0.001).Conclusion: Long-term use of tamoxifen in breast cancer patients increases the risk of endometriosis
Co-Authors Agreno, Marshal Arifki, Azwar Erdani, Ferry Fachrul Razi Imam Hidayat Ismy, Jufriady Meildi, Maria Muharram, Girry Gustianugraha Razi, Khalikul