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Khonsa
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Engineering Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Physics Other

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The Effectiveness Test of Tembelekan (Lantana camara L.) Leaf Extract Gel for Cuts Healing in Male White Mice Khonsa
Media Farmasi Indonesia Vol. 20 No. 1 (2025): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v20i1.288

Abstract

The study of natural products as an alternative medicine to speed up the cuts healing process has become a popular topic of scientific research. One of the plants is Tembelekan (Lantana camara L.) leaves. Its formulation into a gel form can increase drug release. This study aims to determine the effectiveness of Tembelekan leaf extract gel preparations for healing cut wounds in male white mice. The method used in this research was an experimental method on 5 groups with 5 mice in each group. The positive control group was given Bioplacenton®, the negative control group was given gel base, and the treatment group was given 10%, 15%, and 20% Tembelekan leaf extract gel. The gel was applied to the wound twice a day and the observation used Linkert scale. Based on the results of the Kruskal Wallis test, an Asymp.Sig value of 0,030 < 0,050 was obtained, indicating that Tembelekan leaf extract gel was effective in healing cuts. Tembelekan leaf extract gel with varying concentrations of 10%, 15% and 20% has an effect of healing cuts in male white mice. The fastest healing of cuts occurred within 9 days with Tembelekan leaf extract gel with a concentration of 20%. Keywords: Tembelekan, cuts, wound healing, gel, effectiveness test
Uji Efektivitas Pemberian Salep Ekstrak Ikan Patin (PANGASIUS SP.) Terhadap Penyembuhan Luka Bakar Stadium II Kronik Tertutup Pada Tikus Putih Jantan Galur Wistar Khonsa; Rini Setiawati
Journal Transformation of Mandalika, e-ISSN: 2745-5882, p-ISSN: 2962-2956 Vol. 4 No. 10 (2023): Oktober
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jtm.v4i10.2234

Abstract

Luka bakar merupakan suatu bentuk kerusakan atau kehilangan jaringan. Luka bakar stadium II mengalami kerusakan pada seluruh bagian dermis hingga hampir mengenai hipodermis. Ikan patin merupakan bahan alam yang dapat dimanfaatkan sebagai bahan obat pada luka. Tujuan penelitian ini untuk mengetahui bahwa salep fase minyak ekstrak ikan patin memiliki efektivitas terhadap penyembuhan luka bakar stadium II kronik tertup pada tikus putih jantan galur wistar. Penelitian ini menggunakan 20 ekor tikus dan dibagi menjadi 5 kelompok yaitu kelompok kontrol normal, kelompok kontrol positif (krim burnazin), kelompok kontrol negatif (basis salep), kelompok kontrol salep fase minyak ekstrak ikan patin konsentrasi 10% dan 20% terhadap 4 ekor tikus dengan luka bakar stadium II dan pengamatan dilakukan sampai hari ke-17 perlakuan. Luas area luka diukur dengan program Macbiophotonic image J, dihitung % daya penyembuhan dan nilai AUC. Uji statistik terhadap rata-rata nilai AUC per tikus dengan program SPSS for Windows 22.0 menggunakan One Way ANOVA dan Post hoc Test-LSD. Hasil analisis menunjukkan bahwa tidak terdapat perbedaan signifikan (p>0,05) antara kelompok perlakuan dengan kelompok kontrol negatif (AUC = 596,25 % x hari) dan kontrol normal (AUC = 596,85 % x hari). Hal ini mengindikasikan bahwa salep fase minyak ekstrak ikan patin tidak memiliki efektivitas penyembuhan bakar stadium II kronik tertutup pada tikus jantan galur wistar.
Co-Authors Aida Mawaddah Rini Setiawati Rini Setiawati