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All Journal International Journal of Public Health Science (IJPHS) Pharmaceutical Sciences and Research (PSR)
James, Richard Johari
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Health Professions

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Exploring Rosella (Hibiscus sabdariffa L.) Calyx Extracts as Natural Dye and Antioxidants in Lip Cream Product: Formulation and Evaluation Ariestanti, Donna Maretta; Mun'im, Abdul; Djajadisastra, Joshita; Hutami, Riska Amalia Putri; Fadhila, Redhalfi; James, Richard Johari
Pharmaceutical Sciences and Research Vol. 10, No. 3
Publisher : UI Scholars Hub

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Abstract

Rosella, also known as Hibiscus sabdariffa L., is a plant that contains anthocyanin compounds in its calyx, which are known for their antioxidant properties. These compounds give the plant a captivating red color and can be used as natural dyes. This study aimed to exploit anthocyanins in rosella calyx as natural dyes and antioxidants in lip cream product. The formulations employed extracts from rosella calyx, a viscous extract from maceration in 96% ethanol (F1) and a commercially available powdered rosella extract (F2). Evaluation on the formulations demonstrated that both F1 and F2 effectively maintained the color integrity of the lip cream. Moreover, an irritation test among 10 respondents showed no adverse reactions. Additionally, a hedonic test of 30 respondents revealed uniformity in homogeneity, odor, and spreadability on both formulations. However, a noticeable contrast emerged in color intensity, with F2 exhibiting greater intensity and preference over F1. The rosella calyx extract also demonstrated its antioxidant potential with an IC50 value of 130.11 ± 2.08 µg/ml. The study highlights the utility of rosella calyx extracts as a dual-functioning component in lip cosmetics. The findings indicate the variations in formulation efficacy and color intensity, emphasizing the potential of rosella-derived extracts in developing cosmetics with enhanced aesthetic appeal and functional antioxidant attributes.
Antioxidant Activities and Protective Effects of Shorea macrophylla Leaf and Bark Extracts Ramli, Salfarina; Sukri, Nik Nor Sabrina; Zulkifli, Nur Adhwa’ Faqihah; Ariestanti, Donna Maretta; Choo, Chee Yan; Halim, Hasseri; Manshoor, Nurhuda; James, Richard Johari
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

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Shorea macrophylla, also known as the ‘Engkabang’ tree or Light Red Meranti, is renowned for its role in reforestation efforts. Despite lacking records of traditional use, the reported biological activities of other species within the Shorea genus spark curiosity about the potential biological activities of this plant. Therefore, this study aims to explore the antioxidant capabilities of S. macrophylla leaf and bark extracts, along with their protective effects against oxidative stress using a brine shrimp model. In the evaluation of antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays were employed. Extracts were incubated in DPPH and FRAP solutions, and absorbances were measured at 517 and 593 nm, respectively. The brine shrimp lethality assay (BSLT) involved exposing brine shrimps (Artemia salina) to various concentrations of the extract, with LC50 values determined through probit regression analysis. Oxidative stress protection assays entailed treating brine shrimps with safe doses of S. macrophylla extracts before exposure to H2O2, with subsequent observation of survival rates. The DPPH assay unveiled IC50 values of 1.025 and 0.693 mg/mL for S. macrophylla leaf and bark extracts, respectively, while FRAP values exhibited a concentration-dependent relationship. BSLT demonstrated concentration-dependent mortality, with LC50 values of 0.93 and 0.6455 mg/mL for S. macrophylla leaf and bark extracts, respectively. Pre-treatment with S. macrophylla extracts significantly increased brine shrimp survival against H2O2-induced oxidative stress. In conclusion, both S. macrophylla leaf and bark water extracts demonstrated noteworthy antioxidant activities and exhibited protective effects against oxidative stress in brine shrimps. These findings provide insights into the antioxidant activities and protective effects of S. macrophylla Leaf and Bark extracts.
Protective effect of Carica papaya leaves against oxidative stress in brine shrimps James, Richard Johari; Halim, Hasseri; Nasir, Mohd Mursyidul Amin; Amiruddin, Fatimatul Huda; Nor Hazalin, Nurul Aqmar Mohamad
International Journal of Public Health Science (IJPHS) Vol 12, No 3: September 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i3.22494

Abstract

Carica papaya, a type of tree from the Caricaceae family, is renowned for its medicinal benefits due to its diverse chemical composition. The leaves of Carica papaya, in particular, are commonly used in traditional medicine for their purported anti-dengue, anti-malarial, antioxidant, and anti-inflammatory properties. However, despite their widespread use, there is limited research available on the antioxidant characteristics of Carica papaya leaves. This study aimed to examine the potential protective effects of Carica papaya leaves methanolic (CPLM) extract against oxidative stress in Artemia salina (brine shrimp). To evaluate the antioxidant potential of CPLM extract, two commonly used antioxidant activity assays, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing antioxidant power (FRAP) assays, were performed. Additionally, an oxidative stress protection assay was carried out by exposing ten Artemia salina nauplii to CPLM extract for one hour before exposing them to hydrogen peroxide (H2O2). The results of this study showed that the CPLM extract has antioxidant properties. Additionally, the oxidative stress protection assay revealed that the CPLM extract increased the survival rate of Artemia salina nauplii exposed to H2O2. The study suggests that the CPLM extract obtained from Carica papaya leaves possesses antioxidant properties. It can provide protection against oxidative stress caused by hydrogen peroxide in Artemia salina.
Co-Authors Amiruddin, Fatimatul Huda Ariestanti, Donna Maretta Choo, Chee Yan Fadhila, Redhalfi Halim, Hasseri Hutami, Riska Amalia Putri Joshita Djajadisastra, Joshita Manshoor, Nurhuda Mun'im, Abdul Nasir, Mohd Mursyidul Amin Nor Hazalin, Nurul Aqmar Mohamad Ramli, Salfarina Sukri, Nik Nor Sabrina Zulkifli, Nur Adhwa’ Faqihah