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All Journal Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Sains dan Teknologi
Suzan Astyamalia
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Uji Aktivitas Antibakteri Ekstrak Etanol Kombinasi Daun Kepel (Stelechocarpus Burahol) dan Pegagan (Centella Asiatica) Suzan Astyamalia; Maulana Tegar Aditya Nugraha; Ferli Eko
INSOLOGI: Jurnal Sains dan Teknologi Vol. 2 No. 2 (2023): April 2023
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v2i2.1832

Abstract

Kepel and pegagan (kola) leaves have been used as traditional- medicine. Combination kepel and pegagan leaves wasn’t known exactly how its antibacterial activity yet. The purpose of this study was to determine the combination ethanol extract of kepel and kola leaves as antibacterial activity. The method of this study is the well diffusion method. The data were analyzed using quantitative descriptive methods to obtain the minimum, maximum, mean and standard deviation values for the data. The analysis used a descriptive method to explain the antibacterial activity of the ethanol extract of kepel and pegagan leaves against Escherichia coli and Staphylococcus epidermidis with the ratio of kepel and pegagan leaves in extracts 10:90, 30:70, 50:50, 70:30 and 90:10. The results showed that Escherichia coli bacteria had the largest inhibitory diameter in a combination of 70 parts of Kepel leaves and 30 parts of pegagan leaves with an inhibitory diameter of 0.800 cm, while for gram-positive bacteria, Staphylococcus epidermidis, the optimal inhibitory diameter was 0.950 cm in a combination of 40 parts kepel leaves and 60 parts of pegagan leaves. The combination of kepel and pegagan leaves is in providing bacterial inhibition. Escherichia coli bacteria are bacteria that are commonly found in the digestive tract and Staphylococcus epidermidis which generally causes acne.
Formulasi dan Karakterisasi Nanopartikel Ekstrak Biji Carica (Carica pubescens) dengan Variasi Konsentrasi Kitosan menggunakan Metode Gelasi Ionik Fania Putri Luhurningtyas; Prashinta Nita Damayanti; Suzan Astyamalia; Mir-a Kemila; Evi Novitasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39161

Abstract

Carica seeds (Carica pubescens) contain alkaloid, saponin, and flavonoid compounds, which have pharmacological activities such as antibacterial, anti-inflammatory, immunomodulatory, and antihyperlipidemic properties, but their bioavailability is low. Nanotechnology has significantly advanced in drug delivery systems because it can enhance absorption in the gastrointestinal tract, allowing entry into the bloodstream. This study aims to create and evaluate the characteristics of carica seed extract nanoparticles with varying concentrations of chitosan. The carica seed extract was obtained using the maceration method with 70% ethanol as the solvent. The Carica seed extract was then formulated into nanoparticles using the ionic gelation method with varying concentrations of chitosan: NaTPP, specifically formulas FA (0.3:1), FB (0.2:1), and FC (0.1:1). The resulting nanoparticle colloids were characterized for particle size, polydispersity index (PDI), percent transmittance (%T), and specific functional groups. The results showed that the particle sizes for formulas FA, FB, and FC were 243.7 nm, 47.96 nm, and 116.6 nm, respectively. The PDI values for formulas FA, FB, and FC were 0.378, 0.357, and 0.52, respectively. The percent transmittance for all three formulas ranged from 99.5% to 99.6%. The characterization of functional groups indicated interactions between the carica seed extract, chitosan, and NaTPP, with the presence of OH, N-H, aliphatic CH, P=O, and PO3 groups. These interactions were observed based on the shift in wavenumbers in the FTIR results for each sample. All carica seed nanoparticle formulas showed particle sizes within the nanometer range (<1000 nm), polydispersity indices less than 1, percent transmittance close to 100%, and specific functional groups indicating interactions between the extract and the coating polymer. Formula FB was the optimal formula, with the smallest nanoparticle size (<100 nm), a PDI value of <0.5, and a percent transmittance of >99%.
Co-Authors Evi Novitasari Fania Putri Luhurningtyas Ferli Eko Maulana Tegar AdityaNugraha Mir-a Kemila Prashinta Nita Damayanti