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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Journal of Fundamental and Applied Pharmaceutical Science
Devi, Reni Selviana
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Medicine & Pharmacology

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In Vivo Antihyperuricemia Activity of Kelubut Leaf Ethyl Acetate Extract (Passiflora foetida, L.) From Samarinda City Mochtar, Chaerul Fadly; Faradillah, Ayu; Bakhtiar, Muh Irham; Devi, Reni Selviana; Husna, Qur’anni Akhwatun; Hafidzah, Elva; Varizza, Fathiah Putri; Aisyiyah, Novia Misnawati
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19171

Abstract

The development of the times creates shifts in lifestyle and eating patterns that trigger hyperuricemia. Hyperuricemia is generally treated with synthetic drugs, but on the other hand, it causes side effects. So the use of natural ingredients such as kelubut leaves can be an alternative treatment. The purpose of this study was to determine the ethyl acetate extract of kelubut leaves has activity as an anti-hyperuricemia. The research uses experimental research methods with a design in the form of a pretest and posttest design. Mice were used and divided into 5 groups, namely the positive control group, the negative control and the group given the extract with three different doses including doses of 250 mg/Kg BW, 125 mg/Kg BW, and 62.5 mg/Kg BW. Mice will be conditioned by hyperuricemia and given different treatments in each group. Data on uric acid levels were analyzed by Kruskal-Wallis and Mann-Whitney. The results of the study showed that administration of the extract at a concentration of 250 mg/Kg BW reduced uric acid levels as much as the positive control group at 120 minutes, but was not statistically different (p0.05) from the positive control. This study concludes that the ethyl acetate extract of kelubut leaves has anti-hyperuricemic activity at a dose of 250 mg/Kg BW showing the best-reducing activity in reducing uric acid levels in mice.
In-Vivo Anti-Inflammatory Activity of Kelubut Leaf Ethyl Acetate Extract (Passiflora foetida L.) from Samarinda City Mochtar, Chaerul Fadly; Devi, Reni Selviana; Hamzah, Hasyrul; Faradillah, Ayu; Hafidzah, Elva; Varizza, Fathiah Putri; Aisyiyah, Novia Misnawati; Husna, Qur'anni Akhwatun
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.18287

Abstract

Kelubut (Passiflora foetida L.), as an anti-inflammatory, is widely found in various regions in Indonesia, including in Central Kalimantan. Its main chemical compounds include alkaloids, phenols, glycosides, flavonoids, and cyanogenic compounds. Flavonoids show more than a hundred kinds of bioactivity, including antipyretic, analgesic, and anti-inflammatory. This study aims to determine the anti-inflammatory activity of kelubut leaf extract (Passiflora foetda L.) against mice (Mus musculus). This research went through a Pretest and Posttest Control Group Design with 5 treatment groups, negative control, positive control, and ethyl acetate extract of kelubut leaves with 3 doses of 250 mg/KgBW, 125mg/KgBW and 62.5 mg/KgBB. Before being given treatment, each treatment group was induced by carrageenin by sub-planar injection into the sole of the left leg of the mouse. Then, the edema developed rapidly and persisted for 6 hours. After being induced by carrageenin, the researchers waited for 30 minutes and measured the volume of edema every 30 minutes to 120 minutes. The inhibition of all groups of ethyl acetate extract of kelubut leaves showed anti-inflammatory activity, but the resulting abilities were different. Inflammation inhibition by ethyl acetate extract at a dose of 250 mg/KgBW was 92.78%, at a dose of  125 mg/KgBW, was 91.76%, and at a dose of 62.5 mg/KgBW was 84.61%. From the results obtained, the ethyl acetate extract group of kelubut leaves at a dose of 250 mg/KgBW had the greatest inflammatory inhibition activity compared to a dose of 125 mg/KgBW and 62.5 mg/KgBW.
POTENSI EKSTRAK ETIL ASETAT DAUN KELUBUT DARI KOTA SAMARINDA SEBAGAI AGEN ANTIHIPERGLIKEMIK Varizza, Fathiah Putri; Mochtar, Chaerul Fadly; Damis, Nur Lutfiah; Elva; Devi, Reni Selviana; Aisyiyah, Novia Misnawati; Husna, Qur’anni Akhwatun; Faradillah, Ayu
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 10 No. 2 (2023)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v10i2.11334

Abstract

Daun kelubut (Passiflora foetida L.) merupakan bahan alam yang dapat digunakan sebagai pengobatan herbal penyakit diabetes melitus. Penelitian ini bertujuan untuk mengetahui potensi ekstrak etil asetat daun kelubut sebagai antihiperglikemia. Digunakan rancangan the pre-posttest control group design dengan 5 kelompok perlakuan (P1: Na-CMC 1% (kontrol negatif), P2: glibenklamid (kontrol positif), P3: ekstrak etil asetat daun kelubut 250mg/kgBB, P4: ekstrak etil asetat daun kelubut 500mg/kgBB dan P5: ekstrak etil asetat daun kelubut 750mg/kgBB). Sebelum pengujian, mencit diinduksi aloksan dengan dosis 150mg/kgBB secara intraperitoneal. Mencit dengan kadar glukosa >200 mg/dL dapat diberikan perlakuan selama 6 jam secara oral. Pengukuran kadar glukosa dilakukan pada jam ke-0, 3, 4 dan 6. Data yang didapatkan lalu dianalisis menggunakan SPSS versi 26 dengan uji ANOVA. Hasil penelitian menunjukkan bahwa kelompok uji ekstrak etil asetat dengan dosis 750mg/kgBB memiliki kemampuan dalam menurunkan kadar glukosa darah terbaik karena mendekati hasil dari kontrol positif glibenklamid sebagai pembanding. Perbedaan dosis juga mempengaruhi kadar glukosa darah, semakin tinggi dosis yang diberikan, maka efektivitasnya semakin meningkat.
Co-Authors Aisyiyah, Novia Misnawati Chaerul Fadly Mochtar Damis, Nur Lutfiah Elva Faradillah, Ayu Hafidzah, Elva Hamzah, Hasyrul Husna, Qur'anni Akhwatun Husna, Qur’anni Akhwatun Muh Irham Bakhtiar Varizza, Fathiah Putri