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All Journal Journal of Fundamental and Applied Pharmaceutical Science Journal of Tropical Pharmacy and Chemistry
Musa, Neksumi
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Antidiabetic Activity of Diospyros mespiliformis on Alloxan-Induced Diabetic Rats Dahiru, Mubarak Muhammad; Musa, Neksumi
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19798

Abstract

The rate of morbidity and mortality attributed to diabetes has become a concern and challenge for individuals and governments. The availability, affordability, and efficacy of plant-based drugs make them an attractive choice for diabetic management in low-income countries and rural communities. Thus, their application in folkloric medicine for diabetic management. This study investigated the antidiabetic activity of the crude ethanol extract (CRE), ethyl acetate (EAF), and aqueous (AQF) fractions Diospyros mespiliformis (DM) in alloxan-induced diabetic rats to justify its acclaimed applications in folkloric medicine. The effect of the plant extract and its fractions on the aspartate aminotransferase, glutamyl aminotransferase, albumin, urea, creatinine, electrolytes, and lipid profile was determined by biochemical assay methods. The result showed a significant (p 0.05) decrease in fasting blood glucose for all the extracts, while the aspartate aminotransferase, gamma-glutamyl transferase, and albumin were significantly (p 0.05) decreased in the EAF only. The urea and creatinine levels of the CRE and AQF were decreased significantly (p 0.05), while K+, Cl-, and HCO3- levels decreased significantly (p 0.05) for the treatment groups. Furthermore, a significant (p 0.05) decrease in total cholesterol and triglyceride was observed for the EAF. Conclusively, DM exhibited significant hypoglycemic and hypolipidemic potential with improved lipid profile and hepato-renal function. Thus, the observed antidiabetic activity of the plant might justify its acclaimed utilization in the treatment/management of diabetes and its related ailment.    
Crude Ethanol Extract of Diospyros mespiliformis Hochst. ex A. DC. Ebenaceae Leaf and Its Fractions Ameliorate Hyperglycemia and Hyperlipidemia in Alloxan-induced Diabetic Rats Dahiru, Mubarak Muhammad; Musa, Neksumi
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 2 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i2.625

Abstract

This study investigated the antidiabetic activity of the crude ethanol extract of Diospyros mespiliformis (DM) and its ethyl acetate (EEF) and aqueous (AQF) fractions on alloxan-induced diabetic rats. The result indicated a significant (p < 0.05) decrease and improvement in fasting blood glucose (FBG) level and body weight, respectively. The treatment groups exhibited a significantly (p < 0.05) decreased aspartate aminotransferase (AST) level (100-117 IU/L) and decreased gamma-glutamyl transferase (GGT) level in the EEF (4.80 ± 1.02 IU/L) and AQF (5.80 ± 0.80 IU/L) groups only. All the extract-treated groups exhibited a significant increase (p < 0.05) in urea and creatinine levels than the naïve control group (6.94 ± 0.20 mM/L). Moreover, the Na+ remained significantly (p > 0.05) unchanged while the K+ level was significantly (p < 0.05) increased for the treatment groups. The HCO3- of the treated groups increased significantly (p < 0.05) except for the AQF (21.60 ± 1.63 mM/L) group. The total cholesterol and triglyceride levels decreased significantly (p < 0.05) for the treatment groups while the high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) levels remained unchanged but significantly higher than the metformin group. DM possesses significant hypoglycemic and hypolipidemic activity lowering hyperglycemia and hyperlipidemia, and improving body weight and diabetic markers.
Co-Authors Badgal, Enoch Buba Dahiru, Mubarak Muhammad