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All Journal Jurnal Medika Malahayati International Journal of Psychology and Health Science
Ardanayasa, I Gede Risnawan Suastika
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PILIHAN MANAJEMEN PASCA PAJANAN ANTRAKS PADA MANUSIA: KAJIAN LITERATUR Parmelia, Manik; Ardanayasa, I Gede Risnawan Suastika; Kenwa, Komang
Jurnal Medika Malahayati Vol 7, No 4 (2023): Volume 7 Nomor 4
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v7i4.11285

Abstract

Abstrak: Pilihan untuk Manajemen Pasca Pajanan Antraks pada Manusia: Sebuah Telaah Sistematis. Anthrax adalah penyakit zoonosis yang disebabkan oleh bakteri bacillus anthracis. Manajemen yang cepat dan tepat diperlukan untuk mencegah hasil yang merugikan pada pasien antraks pada manusia. Tulisan ini bertujuan untuk menjelaskan lebih lanjut terapi yang tersedia untuk manajemen pasca paparan antraks. Pencarian PubMed dilakukan untuk ‘human anthrax’ AND ‘treatment’ dari database selama 10 tahun terakhir. Sebanyak 1.449 artikel ditemukan dan 8 studi ditelaah lebih jauh. Delapan penelitian menunjukkan beberapa pilihan post-exposure prophylaxis (PEP) untuk antraks pada manusia, terutama anthrax  inhalasi, yaitu imunoglobulin, raxibacumab, obiltoxaximab, dan beberapa jenis yang masih dalam pengembangan, seperti AV7909 dan Px563L. Telaah sistematis ini menunjukkan bahwa setiap penelitian menunjukkan konsentrasi antraks yang bertahan lama dan dalam jumlah yang tinggi dalam sirkulasi sehingga menunjukkan terapi imunoglobulin dapat berperan sebagai profilaksis pasca pajanan yang baik dengan menunjukkan respons imun yang adekuat pada orang sehat.
The Role of Folic Acid Supplementation in Reducing Anemia Complications in Patients with Chronic Kidney Disease: A Systematic Analysis of Randomized Controlled Trials Eryana, I Made; Ardanayasa, I Gede Risnawan Suastika
International Journal of Psychology and Health Science Vol. 3 No. 4 (2025): International Journal of Psychology and Health Science (October - December 2025
Publisher : Greenation Publisher & Yayasan Global Research National

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/ijphs.v3i4.1603

Abstract

Chronic Kidney Disease (CKD) is a global health issue with an increasing prevalence, particularly among the elderly population. One of the major complications of CKD is anemia, which negatively impacts patient outcomes, leading to reduced quality of life and increased morbidity and mortality. Folic acid supplementation has been proposed as an effective intervention for managing anemia in CKD patients, but its clinical impact remains controversial. This systematic review aims to evaluate the role of folic acid supplementation in reducing anemia-related complications in CKD patients. Methods: A systematic search was conducted using PubMed, Science Direct, Google Scholar, and the Cochrane Library for randomized controlled trials (RCTs) published between 2014 and 2024. Included studies were those assessing the effects of folic acid supplementation on anemia in CKD patients. The Cochrane Risk of Bias Tool was used to assess the quality of the studies. Data on hemoglobin levels, erythropoiesis-stimulating agent (ESA) use, and other anemia-related outcomes were extracted and synthesized narratively. Results: Five RCTs involving 681 patients were included. Folic acid supplementation consistently improved hemoglobin levels and sideremia in CKD patients across all studies. Three studies reported significant reductions in inflammation markers. One study demonstrated a protective effect of folic acid against contrast-induced nephropathy. Adverse events were rare, with only one study reporting a slight increase in uric acid levels in some patients. Discussion: Folic acid supplementation appears to be an effective and safe intervention for improving anemia in CKD patients, particularly in those with resistance to conventional iron therapies. The benefits include improved hemoglobin levels, reduced inflammation, and potential protection against nephropathy. However, further long-term studies are needed to evaluate the stability of these effects and their impact on patient outcomes.
Co-Authors Eryana, I Made Kenwa, Komang Parmelia, Manik