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All Journal Majalah Kedokteran Bandung Journal of Biomedicine and Translational Research CRJIM (Clinical and Research Journal in Internal Medicine) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Putra, Mega Memory Rahasa
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Revealing the Potency of Camelia sinensis and Serenoa repens as Purinoreceptor Inhibitor for Benign Prostatic Hyperplasia Treatment through in Silico Study Putra, Mega Memory Rahasa; Seputra, Kurnia Penta
Journal of Biomedicine and Translational Research Vol 10, No 2 (2024): August 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i2.21211

Abstract

Background: Benign prostatic hyperplasia (BPH) is the most common prostate disease in elderly men that leads to a significant deterioration in patients' quality of life (QoL). Pharmacological therapy of 5-alpha reductase inhibitor and alpha adrenoreceptors blocker often causes several side effects that decrease the QoL, so it is necessary to develop a new treatment for BPH. Purinoreceptor is a novel receptor that can inhibit electrically evoked nerve-mediated contractions in the prostate. Tea leaves (Camellia sinensis) and Saw palmetto (Serenoa repens) are herbs that have potential as alternative therapies for BPHObjective: to reveal the mechanism of Camellia sinensis and Serenoa repens through purinoreceptor and the other receptorsMethods: Structures of active compounds were extracted from PubChem and protein from PBD. The active compounds Camellia sinensis and Serenoa repens to the target protein purinoreceptors, 5-alpha-reductase, and alpha adrenoreceptors was evaluated in silico using a docking server with Finasteride dan Tamsolusin as a control. Molecular docking method using dockingserver application.Results: Epigallocatechin gallate only compound that has potency in blocking purinoceptors and 5-alpha-reductase. Capric acid, Caprylic acid, Lauric acid, Linoleic acid, and Myristic acid have the potential to bind to alpha adrenoreceptor ligands.Conclusion: Camellia sinensis have potential and effects as alternative therapies in benign prostatic hyperplasia on the target protein purinoreceptors, 5-alpha-reductase, and alpha adrenoreceptors. But, Serenoa repens have potential only through alpha adrenoreceptors.
The impact of coblation and non-coblation techniques on hemorrhage and pain outcomes in tonsillectomy: A meta-analysis Kuncahyo, Sandi Dwi; Putra, Mega Memory Rahasa; Istyawati, Ersty
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 1, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss1.art13

Abstract

Tonsillectomy, a common surgical procedure, carries significant complications, including haemorrhage and postoperative pain, impacting patient morbidity and mortality. This study explores the effectiveness of coblation compared to traditional non-coblation techniques in managing these complications. Coblation, proposed to reduce risks associated with tissue removal, was evaluated through a systematic literature search using databases such as PubMed, Google Scholar, and Cochrane. The selected studies were rigorously analysed based on specific inclusion and exclusion criteria. Results from ten journals included in this review indicate no significant difference in primary haemorrhage outcomes between coblation and non-coblation techniques (odds ratio 1.49; 95% CI: 0.68-3.23; p=0.32), with low heterogeneity (I²=0%; p=0.81). However, coblation was associated with a statistically significant reduction in secondary haemorrhage (odds ratio 0.66; 95% CI: 0.45-0.95; p=0.03) and postoperative pain (effect size -0.84; 95% CI: -0.94 to -0.74; p < 0.00001). These findings suggest that coblation may be more effective in reducing secondary haemorrhage and postoperative pain compared to non-coblation techniques.
Correlation Between Anemia, Sexually Transmitted Infections, and Low Birth Weight Among Pregnant Women Suprapto, Elviara Martha Tinova; Putra, Mega Memory Rahasa; Bangun, Thomas Yan; Azizah, Nur
Majalah Kedokteran Bandung Vol 57, No 3 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.4212

Abstract

Anemia in pregnancy and sexually transmitted infections (STIs) are global health issues linked to low birth weight. This study explored the correlation between these factors and low birth weight at the General Hospital of Scholoo Keyen, South Sorong, Southwest Papua, Indonesia. A cross-sectional observational analytic study was conducted from September 2022 to March 2023, involving pregnant women who gave birth at the General Hospital of Scholoo Keyen. The correlation between risk factors and low birth weight was analyzed using the chi-square test with a significance threshold of p<0.05. Results showed that among 162 pregnant women (average age: 27.72±6.62 years), anemia severity was distributed as follows:severe (3.7%), moderate (16.0%), and mild (40.1%). However, no significant relationship was found between anemia and birth weight (p=0.850, p>0.05). The incidences of HIV, syphilis, and hepatitis B were 3.1%, 13.6%, and 7.4%, respectively. A significant association was identified between HIV infection and low birth weight (p=0.000), while no such association was found for syphilis (p=0.160) or hepatitis B infection (p=0.852). In conclusion, HIV infection is associated with low-birth-weight newborns, but there are no apparent relationships between anemia, syphilis, or hepatitis B infection and low-birth-weight newborns, This study implies the importance of nutritional support among pregnant mothers with HIV and delaying pregnancy in HIV-positive women to until their immune system improve.
The Acute respiratory distress syndrome in clinical tuberculosis patients with ventricular extrasystole: The Acute respiratory distress syndrome as complication clinical tuberculosis patients Yahya, Moh. Yahya Al-Hilal; Putra, Mega Memory Rahasa
Clinical and Research Journal in Internal Medicine Vol. 6 No. 2 (2025): Volume 6 No 2, November 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2025.006.02.13

Abstract

Tuberculosis (TB) is a global health issue that can lead to severe pulmonary damage and systemic complications. Ventricular extrasystole, a type of arrhythmia, is not commonly associated with TB. A 25-year-old female with a history of pulmonary TB was admitted to the intensive care unit with severe dyspnea, cough, and fever. The patient was diagnosed with ARDS and found to have ventricular extrasystoles on the electrocardiogram (ECG). The patient was managed with a multidisciplinary approach that included mechanical ventilation, initiation of anti-tubercular therapy, and anti-arrhythmic medications. The management strategy focused on stabilizing the patient's respiratory and cardiac status while treating the underlying TB infection. The patient was discharged after 5 days of hospitalization and continued the anti-TB regimen.
Co-Authors Bangun, Thomas Yan Istyawati, Ersty Kuncahyo, Sandi Dwi Kurnia Penta Seputra Nur Azizah Suprapto, Elviara Martha Tinova Yahya, Moh. Yahya Al-Hilal