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All Journal Journal of Islamic Pharmacy Eksakta : Berkala Ilmiah Bidang MIPA
Almutahrihan, Irsan Fahmi
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health

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Analisis Jejaring Farmakologi Tanaman Jati Belanda (Guazuma ulmifolia Lamk.) Sebagai Imunomodulator Lena, Nour; Jamil, Ahmad Shobrun; Muchlisin, M. Artabah; Almutahrihan, Irsan Fahmi
Journal of Islamic Pharmacy Vol 8, No 1 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i1.20782

Abstract

Covid-19 merupakan wabah penyakit yang menginfeksi sistem pernafasan pada manusia. Kasusnya terjadi hampir di seluruh negara di dunia dan keberadaannya sangat meresahkan karena penyebarannya terjadi dengan sangat cepat. Salah satu upaya yang dapat dilakukan untuk mencegah penyebaran penyakit Covid-19 adalah dengan meningkatkan sistem imun. Sistem imun melindungi tubuh dari infeksi dengan memproduksi molekul protein yang disebut antibodi yang mengikat antigen agen infeksi. Berdasarkan studi literatur yang telah dilakukan, beberapa tanaman lokal Indonesia memiliki potensi sebagai imunomodulator. Fokus penelitian ini ditujukan untuk mengetahui jejaring protein yang terkait dengan sistem imun tubuh yang teraktivasi karena pemberian ekstrak tanaman jati belanda (Guazuma ulmifolia Lamk.). Metode penelitian yang digunakan adalah deskriptif eksploratif berdasarkan online database dan web server (KNApSAck Family, Dr. Duke’s Phytochemical and Ethnobotanical Databases, SwissTargetPrediction, GeneCards, SwissADME, Venny, dan StringDB). Berdasarkan hasil penelitian, tanaman G. ulmifolia mengandung 17 senyawa metabolit sekunder, lima diantaranya memiliki bioavailabilitas yang tinggi meliputi ent-catechin, (-)-epigallocatechin, caffeine, kaempferol, dan quercetin. Senyawa (-)-epigallocatechin diprediksi dapat berinteraksi dengan MAPK14 yang memiliki koneksi dengan lima jalur penting dalam imunomodulator yaitu Fc epsilon RI signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, THF17 cell differentiation, TNF signaling pathway, dan IL-17 signaling pathway.
In Silico Study Potential Secondary Metabolite Candidate of Citronella Grass (Cymbopogon nardus) on Immunity Cases Veda, Adella Infia Helga; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Almutahrihan, Irsan Fahmi; Satriawan, Herland
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 03 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol23-iss03/418

Abstract

Foreign invaders in the form of bacteria, fungi, or viruses can cause various diseases if they enter the body, both molecularly and cellularly. Hence, the body needs a compound that can maintain and enhance the immune and immune systems to recognize abnormal cells that can become a source of disease for the body. Improving immunity/resistance for people with diseases is very important so that people undergoing treatment are given immunostimulant drugs or pharmaceutical preparations. This study aimed to determine the protein network associated with the body's immune system, which was activated by the administration of citronella (Cymbopogon nardus). The research method used is explorative descriptive with in silico analysis using a computational model with software including KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, C. nardus contains 40 secondary metabolites, 25 of them have high bioavailability. Based on pharmacological network analysis, (-)-menthol is an important compound that plays a role in the immune system because it is expected to interact with three crucial pathways related to immunomodulators.
Co-Authors Ahmad Shobrun Jamil Lena, Nour Muchlisin, M. Artabah Satriawan, Herland Veda, Adella Infia Helga