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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Nefertiti, Eva Pravitasari
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Identification of Bioactive Compounds from Pedada Fruit Extract (Sonneratia Caseolaris) to Prevent Stunting Damayanti, Azarine Ahnafia; Diarsvitri, Wienta; Nefertiti, Eva Pravitasari; Rahayu, Indri Ngesti
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 1 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i1.7491

Abstract

Stunting is a problem that still cannot be resolved throughout the world, especially in Indonesia. Children who are malnourished show high levels of blood oxidative stress biomarkers as well as inhibition in growth. To understand prevention of stunting, research was conducted using pedada fruit (Sonneratia caseolaris) which is a mangrove plant taken at the Wonorejo Magrove Ecotourism, Rungkut District, Surabaya City, East Java. The results of the research were used to reveal that there are bioactive compounds in pedada fruit extract to prevent stunting. This research used One Shot Experimental Study. The variables studied used primary data from screening of phenolic and flavonoid antioxidant metabolite compounds at the FK UHT Pharmacy Laboratory and screening for Cu, Fe, Zn mineral content at the UPT East Java Nutrition Laboratory. Result: Based on the results of qualitative phytochemical screening, pedada fruit contained phytochemical compounds, namely phenolics and flavonoids. Mineral screening of pedada fruit was carried out using the Atomic Absorption Spectrophotometry (AAS) method. Pedada fruit extract contained zinc (Zn) of 1.057 mg, while copper (Cu) and iron (Fe) of 0 mg.
Oxidative Stress and the Severity of Gastroesophageal Reflux Disease: Is There Any Correlation? Imro'ati, Tri Asih; Sugihartono, Titong; Widodo, Budi; Nefertiti, Eva Pravitasari; Wibawa, I Dewa Nyoman
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 3 (2024): VOLUME 25, NUMBER 3, December, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/253202445-52

Abstract

Background: Oxidative stress plays a crucial role in the inflammatory response of the oesophageal epithelium; hence, therapies that affect oxidative stress may be a new approach in GERD management.  The objective is to analyze and determine the correlation between Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI) with severity of GERD.Methods: This is an observational analytic study using a cross-sectional design,that  conducted at the Endoscopic Unit of three hospitals in Surabaya, which held from June 2020 to March 2021. The 18 to 60 years old subjects who meet the GERD-Q score 8-18 and not meet the exclusion criteria undergo an endoscopic examination to determine the GERD severity and blood test. Data analysis was using the Spearman rank correlation test.Results: This study indicates that most subjects are women, with mean age 39.31±10.99 years, most are GERD grade A, the mean value of TOS, TAS, ISO respectively is 5.18±1.60, 1.58±0.18, and 3.36±1.35. The laboratory test results show insignificant different based on GERD degree.  There is a non-significant positive correlation between TOS and GERD severity, a significant negative correlation  between TAS and  GERD severity, and a significant positive correlation between OSI and GERD severity (respectively, r = 0.121, p = 0.266 vs r = -0.323, p = 0.044 vs r = 0.345, p = 0.033).Conclusion:  The TAS and OSI may be correlated to the GERD severity but still need further investigations. 
The Effect of Hyperbaric Oxygen Therapy on Neutrophil to Lymphocyte Ratio (NLR) in Wistar Strain Female White Rats (Rattus norvegicus) Induced by 7,12-dimethylbenz[a]anthracene (DMBA) Mangkuluhur, Ande; Sudiarta, Ketut Edy; Nefertiti, Eva Pravitasari
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1406

Abstract

Background: Tumors are caused by uncontrolled cell growth, and the immune system plays a crucial role in this process. Neutrophils and lymphocytes are key immune cells involved in tumor behavior. Adenosine and its A2 receptor can activate neutrophils to promote inflammation that may lead to tumor growth. In contrast, lymphocyte especially cytotoxic T cells, can attack and kill tumor cells, helping to reduce tumor growth and inflammation. This study explores how hyperbaric oxygen therapy (HBOT) can influence the neutrophil-to-lymphocyte ratio (NLR) in female Wistar rats exposed to a known carcinogen, 7,12- dimethylbenz[a]anthracene (DMBA).Method: The research followed a post-test-only control group design. Two control groups were established: one that received a normal diet and the other that was treated with DMBA at a dosage of 20 mg/kgBW for four weeks. The treatment group received both the carcinogen and HBOT at 1.7 Atmospheric Absolute for 30 minutes, three times daily for five days. Blood samples were taken, and the NLR was measured using IBM SPSS software version 26. Result: Results showed significant differences in NLR among the groups. The negative control group had a mean NLR of 1.3444, the positive control group had 3.7889, and the treatment group had 1.6889. A statistically significant difference in these mean NLR values (p = 0.000) was observed among Female Wistar Rats subjected to the effects of the carcinogen DMBA combined with HBOT. Conclusion: The study concluded that HBOT significantly reduced NLR values in these rats exposed to the carcinogen. These findings highlight the potential of HBOT as a supportive therapeutic intervention in modulating the tumor-associated immune environment.
Co-Authors Damayanti, Azarine Ahnafia I Dewa Nyoman Wibawa Imro'ati, Tri Asih Indri Ngesti Rahayu Mangkuluhur, Ande Sudiarta, Ketut Edy Titong Sugihartono Widodo, Budi Wienta Diarsvitri