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All Journal Jurnal Ilmu Kesehatan Indonesian Journal of Medical and Pharmaceutical Science
Haq, Mailatul Ilal
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Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Potential of Several Phytochemicals of Mangrove Species (Rhizopora stylosa) as Inhibitor of Both Viral Gene Expression and Bacterial Nucleic Acid Synthesis Hadi, Ismanurrahman; Irawan, Ade; Ulfah, Mariam; Putra, Teguh Adiyas; Efriani, Like; Haq, Mailatul Ilal; Purnama, Muhamad Rifki
Jurnal Ilmu Kesehatan Vol 10 No 1 (2022): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v10i1.3278

Abstract

The mangrove family (Rhizophora stylosa) has been used as traditional medicine. Due to the habitat of mangroves, they develop unique phytochemicals. Thus, they have the potential to become a source of plant-based therapeutic agents. However, many of the them remain uninvestigated. The purpose of this study was to predict the potential of some phytochemicals of the mangrove family as an inhibitor of both viral gene expression and bacterial nucleic acid. Some bioactive compounds of mangrove (taraxerol, pyrethrin, 2-Furancarboxaldehyde, and avicequinone A) were used as subject of this study. The main protease (Mpro) of SARS-Cov-2 virus (PDB ID: 6y2e), the staphylococcus aureus's proteins: topoisomerase II DNA gyrase (PDB id: 2XCT), and tyrosyl-tRNA synthetase (PDB id: 1JIJ) were used as targeted protein. The drug-likeness of compounds were analyzed using Swiss ADME based on the Lipinsky rule of five. Meanwhile, the affinity value between proteins and ligands was predicted using Autodock Vina. The root means square distance (RMSD) value (<2 A) and the binding cavity of drugs (ivermectin and ciprofloxacin) were used as validation parameters. This study resulted that only taraxerol compounds have a violation of Lipinsky's rule. Even so, out of the phytochemical compound of mangrove, the taraxerol has the highest affinity in Mpro and topoisomerase II DNA gyrase protein, although still lesser than ivermectin against Mpro; while avicequinone A has the highest affinity against tyrosyl-tRNA synthetase. This concludes that some phytochemicals of the mangrove family could be developed as an antibacterial and antiviral agents of therapy.
Hubungan Pengetahuan terhadap Perilaku Penggunaan Obat Kumur di Bulan Ramadhan Sabiti, Farroh Bintang; Rochajati, Siti; Haq, Mailatul Ilal
Indonesian Journal of Medical and Pharmaceutical Science Vol. 4 No. 1 (2025)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v4i1.366

Abstract

Background: One of the health problems that often occur during the fasting month is problems with the teeth and mouth. Dental and oral problems are important things to pay attention to. Apart from causing bad breath, this can also affect a person's self-confidence. Generally, dental and oral problems can be prevented by using mouthwash. When using mouthwash during the Ramadhan, it must be done properly and correctly. Good knowledge towards the practice of using mouthwash is very important. Methods: This research is a descriptive study with a cross sectional approach used random sampling techniques. Data analysis used the Spearman test. Results: The category of knowledge of mouthwash medicines at Semarang city health center was 83% in the good category. Meanwhile, in the practice category, 80% were in the good category and 20% were in the bad category. Conclusion: There is a relationship between knowledge and public attitudes regarding the practice of selecting halal herbal medicines in pharmacies. Where the significant values are between knowledge and practice using mouthwash at ramadhan (0.00*),
Potential of Several Phytochemicals of Mangrove Species (Rhizopora stylosa) as Inhibitor of Both Viral Gene Expression and Bacterial Nucleic Acid Synthesis Hadi, Ismanurrahman; Irawan, Ade; Ulfah, Mariam; Putra, Teguh Adiyas; Efriani, Like; Haq, Mailatul Ilal; Purnama, Muhamad Rifki
Jurnal Ilmu Kesehatan Vol 10 No 1 (2022): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v10i1.3278

Abstract

The mangrove family (Rhizophora stylosa) has been used as traditional medicine. Due to the habitat of mangroves, they develop unique phytochemicals. Thus, they have the potential to become a source of plant-based therapeutic agents. However, many of the them remain uninvestigated. The purpose of this study was to predict the potential of some phytochemicals of the mangrove family as an inhibitor of both viral gene expression and bacterial nucleic acid. Some bioactive compounds of mangrove (taraxerol, pyrethrin, 2-Furancarboxaldehyde, and avicequinone A) were used as subject of this study. The main protease (Mpro) of SARS-Cov-2 virus (PDB ID: 6y2e), the staphylococcus aureus's proteins: topoisomerase II DNA gyrase (PDB id: 2XCT), and tyrosyl-tRNA synthetase (PDB id: 1JIJ) were used as targeted protein. The drug-likeness of compounds were analyzed using Swiss ADME based on the Lipinsky rule of five. Meanwhile, the affinity value between proteins and ligands was predicted using Autodock Vina. The root means square distance (RMSD) value (<2 A) and the binding cavity of drugs (ivermectin and ciprofloxacin) were used as validation parameters. This study resulted that only taraxerol compounds have a violation of Lipinsky's rule. Even so, out of the phytochemical compound of mangrove, the taraxerol has the highest affinity in Mpro and topoisomerase II DNA gyrase protein, although still lesser than ivermectin against Mpro; while avicequinone A has the highest affinity against tyrosyl-tRNA synthetase. This concludes that some phytochemicals of the mangrove family could be developed as an antibacterial and antiviral agents of therapy.
Co-Authors Ade Irawan Efriani, Like Hadi, Ismanurrahman Purnama, Muhamad Rifki Putra, Teguh Adiyas Rochajati, Siti Sabiti, Farroh Bintang Ulfah, Mariam