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All Journal Jurnal Periodic Jurusan Kimia UNP Jurnal SOLMA Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ ABDIMAS SILIWANGI Walisongo Journal of Chemistry Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Dunia Farmasi Jurnal Ilmu Kesehatan Best Journal (Biology Education, Sains and Technology) HERBAPHARMA : Journal of Herb Farmacological Jurnal Insan Farmasi Indonesia Journal of Fundamental and Applied Pharmaceutical Science Indonesian Community Journal Ekalaya: Jurnal Pengabdian Kepada Masyarakat Indonesia Journal Of Medicine And Health Sciences (Medisci)
Ulfah, Mariam
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Antibacterial Effectiveness of BS Endophyte Mushroom Extract on Media Growing Red Rice Iryani, Iryani; Pramesti, Radia Sagita; Riga, Riga; Ulfah, Mariam
Walisongo Journal of Chemistry Vol 6, No 1 (2023): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v6i1.13241

Abstract

BS endophytic Fungi is a Fungi isolated from the flower of the bitter plant (A. Paniculata) which is known to produce various secondary metabolites which are reported to have antibacterial bioactivity. This study aimed to determine the antibacterial activity of extract from endophytic Fungi BS isolated from bitter flower (A. Paniculata) on brown rice growing media against Streptococcus mutans, Staphylococcus aureus, and Pseudomonas aeruginosa bacteria. The method used is endophytic Fungi BS grown on media extracted by maceration method with solvent. The antibacterial activity test of the extract was carried out by disc diffusion method. The results obtained showed that the extract of the endophytic Fungi BS grown on brown rice media gave activity to inhibit the growth of Streptococcus mutans, Staphylococcus aureus, and Pseudomonas aeruginosa bacteria at concentrations of 10%, 30%, and 50%. In conclusion, the extract of BS endophytic Fungi isolated from A. paniculata flowers has potential as an antibacterial
Aktivitas Antibakteri Fraksi n-Heksana Kulit Nanas (Ananas comosus) Terhadap Bakteri Staphylococus aureus Dan Escherichia coli Ulfah, Mariam; Hadi, Ismanurrahman; oliviana, Resya
HERBAPHARMA : Journal of Herb Farmacological Vol. 6 No. 1 (2024): Volume 6 Nomor 1 Juni 2024
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v6i1.403

Abstract

Kulit nanas (Ananas comosus) di Indonesia umumnya hanya dibuang begitu saja sebagai limbah, padahal kulit nanas memiliki senyawa kimia yang berpotensi sebagai antibakteri. Kulit nanas mengandung senyawa flavonoid, tanin, vitamin C, karotenoid, alkaloid, terpenoid dan saponin. Penelitian ini bertujuan untuk mengetahui kandungan senyawa metabolit sekunder fraksi n-heksana kulit nanas dan melakukan uji antibakteri terhadap fraksi n-heksana kulit nanas. Penelitian ini dilakukan secara eksperimen, kulit nanas diekstraksi dengan metode maserasi menggunakan pelarut etanol 96% kemudian di fraksinasi dengan metode partisi menggunakan pelarut n-heksan. Fraksi n-heksana dengan konsentrasi 25%, 50% dan 75% kemudian diuji antibakterinya. Kloramfenikol digunakan sebagai kontrol positif dan DMSO sebagai kontrol negatif. Uji antibakteri dilakukan dengan metode difusi cakram.  Hasil penelitian ini menunjukkan bahwa fraksi n-heksana kulit nanas mengandung senyawa alkaloid, flavonoid, saponin, terpenoid. Hasil uji antibakteri fraksi n-heksana kulit nanas menunjukkan bahwa fraksi n-heksana kulit nanas dengan konsentrasi 75% dapat menghambat bakteri S. aureus dengan nilai zona hambat 12 mm dan terhadap bakteri E. coli dengan zona hambat 12 mm dimana aktivitas antibakteri ini dikategorikan kuat. Dari penelitian ini didapatkan bahwa kulit nanas memiliki potensi yang sangat baik sebagai agen antibakteri dari bahan alam.   ABSTRACTPineapple peel (Ananas comosus) in Indonesia is commonly discarded as waste; however, it contains chemical compounds that have potential as antibacterial agents. Pineapple peel contains flavonoids, tannins, vitamin C, carotenoids, alkaloids, terpenoids, and saponins. This study aims to identify the secondary metabolite compounds in the n-hexane fraction of pineapple peel and to conduct antibacterial tests on this fraction. The research was experimental; pineapple peel was extracted using maceration with 96% ethanol as the solvent, followed by fractionation using n-hexane. The n-hexane fractions at concentrations of 25%, 50%, and 75% were then tested for antibacterial activity. Chloramphenicol served as a positive control, and DMSO as a negative control. Antibacterial testing was performed using the disc diffusion method. The results indicated that the n-hexane fraction of pineapple peel contains alkaloids, flavonoids, saponins, and terpenoids. Antibacterial testing of the n-hexane fraction showed that the 75% concentration inhibited S. aureus and E. coli bacteria with zones of inhibition measuring 12 mm, indicating strong antibacterial activity. This study demonstrates that pineapple peel has great potential as a natural antibacterial agent.
FORMULASI DAN EVALUASI SEDIAAN SABUN MANDI PADAT EKSTRAK ASETON KULIT NANAS MADU (Ananas comosus (L) merr) Hadi, Ismanurrahman; Alfayyasy, Akhmad Irfan; Ulfah, Mariam
HERBAPHARMA : Journal of Herb Farmacological Vol. 5 No. 2 (2023): Volume 5 Nomor 2 Desember 2023
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v5i2.409

Abstract

Kulit nanas madu (Ananas comosus (L) merr) merupakan limbah dari kulit nanas yang sering tidak termanfaatkan. Kulit nanas madu diketahui kaya akan flavonoid yang berperan sebagai antioksidan yang mampu melindung kulit dari paparan radikal bebas. Penelitian ini bertujuan untuk memformulasikan ekstrak aseton kulit nanas madu menjadi sedian topikal sabun mandi padat. Kulit nanas madu diekestrak menggunakan pelarut aseton, lalu diujikan kandungan fitokimianya. Hasil skrining fitokimia menunjukan ekstrak aseton kulit nanas madu positif mengandung flavonoid, saponin, alkaloid dan tanin. Ekstrak diformulasikan menjadi sabun mandi padat dengan konsentrasi 0% (F1), 1% (F2), 3% (F3) ekstrak. Hasil evaluasi menunjukkan karakteristik fisik sabun padat memiliki bentuk padatan solid disertai aroma khas nanas. Selain itu, hasil uji pH dan stabilitas busa berada pada rentang yang baik (pH 9; stabilitas busa selama 5 menit). Meskipun begitu, hasil uji homogenitas menunjukkan adanya ketidakhomogenitasan pada semua rentang konsentrasi. Pada uji kesukaan semua responden menunjukkan adanya kecenderungan suka pada fomula F2. Hasil yang didapat menunjukan formula terbaik dan paling disukai konsumen adalah pada kadar zat aktif 1%.
Uji Aktivitas Antioksidan Ekstrak Aseton Kulit Nanas Madu (Ananas comosus (L) Merr.) Menggunakan Metode DPPH (2,2-Diphenyl-1-picilhidrazyl) Hadi, Ismanurrahman; Prihatiningsih, Sherly; Ulfah, Mariam
HERBAPHARMA : Journal of Herb Farmacological Vol. 6 No. 1 (2024): Volume 6 Nomor 1 Juni 2024
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v6i1.411

Abstract

Antioksidan memegang peranan yang sangat penting dalam kesehatan tubuh manusia karena mampu mencegah atau menetralkan reaksi oksidatif yang melibatkan radikal bebas. Salah satu buah yang berpotensi sebagai antioksidan adalah nanas madu (Ananas comosus (L) Merr.). Tujuan penelitian ini adalah untuk mengujikan aktivitas antioksidan dari kulit nanas madu menggunakan metode 2,2-Diphenyl-1-picilhidrazyl (DPPH). Ekstraksi kulit nanas madu dilalakukan dengan pelarut aseton. Setelah itu ekstrak diidentifikasi senyawa fitokimianya meliputi golongan flavonoid, alkaloid, tanin dan saponin. Hasil identifikasi menunjukkan ekstrak aseton kulit nanas madu positif mengandung flavonoid, alkaloid, saponin dan tanin. Pengujian lanjutan dilakukan untuk mengujikan aktivitas antioksidannya menggunakan metode DPPH. Hasil yang didapat ekstrak aseton kulit nanas madu memiliki nilai IC50 sebesar 42,75mg/mL. Berdasarkan hasil tersebut, ekstrak kulit nanas madu memiliki aktivitas antioksidan yang kuat.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN ASAM JAWA (Tamarindus indica L) TERHADAP BAKTERI Propionibacterium acne DAN BAKTERI Pseudomonas aeruginosa Irawan, Ade; Ulfah, Mariam; Fadillah, Aulia Nur Indri
HERBAPHARMA : Journal of Herb Farmacological Vol. 5 No. 2 (2023): Volume 5 Nomor 2 Desember 2023
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v5i2.420

Abstract

The goal of this research is to find out the capability of tamarind leaf ethanol extract (Tamarindus indica Linn) to inhibit the maturationof Propiomibacterium acnes and Pseudomonas aeruginosa bacteria as well as the optimal concentration of tamarind leaf extract that can do so. Using 96% ethanol as a solvent, maceration was used for extraction. Antibacterial activity testing uses the agar diffusion method by means of discs. According to studies on the antibacterial action of tamarind leaf ethanol extract opposed tothe bacteria Propionibacterium acne and Psedomonas aeruginosa, at a concentration of 20%, the extract can already block the development of bacteria in the medium range, while at a concentration of 80%, the extract can inhibit bacterial growth in the strong category. The one-way anova method and the LSD test were used to examine the antibacterial activity test findings. According to Anova data, the test bacteria were suppressed at doses of 20%, 40%, 60%, & 80%. Effective concentrations to inhibit Propionibacterium acne bacteria and Pseudomonas aeruginosa bacteria at concentrations of 20%, 40%, 60%, & 80%. The measurement of the area of bacterial growth inhibition increases with tamarind leaf extract concentration. Flavonoids, alkaloids, saponins, tannins, and steroids can be found in tamarind leaf ethanol extract. Tamarind leaf ethanol extract has antibacterial activity against Propionicaterium acne and Pseudomonas aeruginosa bacteria and has an inhibition zone at 80% concentration with an average diameter of 25.83 cm and 17.66 cm.
Formulation of Shampoo from Rice Bran Extract (Oryza sativa) and Essential Oil Pomelo Peel (Citrus maxima) Hadi, Ismanurrahman; Silviyani, Amerta; Ulfah, Mariam
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19328

Abstract

Rice bran (Oryza sativa) is a by-product of rice processing that contains bioactive terpenoid compounds such as oryzanol. This compound has many pharmacological effects such as antioxidant, anti-fungal, anti-bacterial, etc. On the other hand, the essential oil of pomelo peel (Citrus maxima) has a refreshing aroma and also contains a variety of phytochemicals that are efficacious as antioxidants. This study aims to identify optimal formulations of shampoo with a combination of acetone extract from rice bran and essential oil of pomelo peel. Rice bran was extracted using acetone solvent, while essential oil from pomelo peel was obtained by distillation. Phytochemical screening of acetone extract showed the presence of terpenoids, flavonoids, alkaloids, tannins, and saponins. The extracts and essential oil were formulated into shampoo into 4 groups (FI, FII, FIII, FIV), which respectively contained 0%, 10%, 15%, and 20% extract. The results showed the evaluation of the best physical shampoo in Formula III because volunteers preferred Formula III and its better foam stability. Based on these results, it can be concluded that the acetone extract of rice bran and the essential oil of pomelo  peel could be formulated into good shampoo.
Alpha Glucosidase Inhibitory Activity of Tiger Milk Mushroom (Lignosus rhinocerus) Ethanolic Extract Ulfah, Mariam; Efirani, Like; Hadi, Ismanurrahman
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.20299

Abstract

Tiger's milk mushroom (TMM) is a plant that can only grow in certain regions in Asia. Indonesia is the country that has the most TMM plants in the world. This plant grows wild in the forests of Kalimantan and Papua. This plant is widely used by people to treat fever, breast cancer and asthma. TMM is known to have various pharmacological activities such as anticancer. The research about TMM originate from Indonesia is still rarely carried out. So, the aim of this research is to carry out an alpha glucosidase inhibition activity test of TMM ethananolic extract. The method used for extraction the TMM is maceration method using ethanol solvent. To identify the secondary metabolite compounds from TMM, phytochemical tests and thin layer chromatography (TLC) tests were carried out.  Inhibition test of alpha glucosidase enzyme activity of TMM ethanolic extract was carried using p-nitrophenyl-alpha-D-glucopyranoside reagent. The results of this phytochemical test are the ethanol extract of TMM contains flavonoid, alkaloid, terpenoid and phenolic compounds. This is confirmed by the TLC test where this test indicates the presence of flavonoid and alkaloid compounds. The results of the alpha glucosidase enzyme inhibition activity test showed that the ethanol extract of tiger milk mushrooms had an IC 50 value of  39.96 ppm which are categorized strong antidiabetic activity. From this research can be concluded that TMM ethanlolic extract very potential as an antidiabetic drug.
Potential of Several Phytochemicals of Mangrove Species (Rhizopora stylosa) as Inhibitor of Both Viral Gene Expression and Bacterial Nucleic Acid Synthesis Hadi, Ismanurrahman; Irawan, Ade; Ulfah, Mariam; Putra, Teguh Adiyas; Efriani, Like; Haq, Mailatul Ilal; Purnama, Muhamad Rifki
Jurnal Ilmu Kesehatan Vol 10 No 1 (2022): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v10i1.3278

Abstract

The mangrove family (Rhizophora stylosa) has been used as traditional medicine. Due to the habitat of mangroves, they develop unique phytochemicals. Thus, they have the potential to become a source of plant-based therapeutic agents. However, many of the them remain uninvestigated. The purpose of this study was to predict the potential of some phytochemicals of the mangrove family as an inhibitor of both viral gene expression and bacterial nucleic acid. Some bioactive compounds of mangrove (taraxerol, pyrethrin, 2-Furancarboxaldehyde, and avicequinone A) were used as subject of this study. The main protease (Mpro) of SARS-Cov-2 virus (PDB ID: 6y2e), the staphylococcus aureus's proteins: topoisomerase II DNA gyrase (PDB id: 2XCT), and tyrosyl-tRNA synthetase (PDB id: 1JIJ) were used as targeted protein. The drug-likeness of compounds were analyzed using Swiss ADME based on the Lipinsky rule of five. Meanwhile, the affinity value between proteins and ligands was predicted using Autodock Vina. The root means square distance (RMSD) value (<2 A) and the binding cavity of drugs (ivermectin and ciprofloxacin) were used as validation parameters. This study resulted that only taraxerol compounds have a violation of Lipinsky's rule. Even so, out of the phytochemical compound of mangrove, the taraxerol has the highest affinity in Mpro and topoisomerase II DNA gyrase protein, although still lesser than ivermectin against Mpro; while avicequinone A has the highest affinity against tyrosyl-tRNA synthetase. This concludes that some phytochemicals of the mangrove family could be developed as an antibacterial and antiviral agents of therapy.
UJI AKTIVITAS ANTIBAKTERI SEDIAAN SABUN PADAT EKSTRAK ETANOL KULIT JERUK BALI (Citrus maxima) TERHADAP BAKTERI Staphylococcus aureus DAN Pseudomonas aeruginosa Putra, Teguh Adiyas; Ulfah, Mariam; Ayu Syarifah, Nyimas
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 1 (2024): Volume 7, No 1, Tahun 2024
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i1.51127

Abstract

Grapefruit (Citrus maxima) has antibacterial activity mostly located in the peel. Compounds that are antibacterial in grapefruit peel (Citrus maxima) are flavonoids. The purpose of this study was to determine the best concentration of solid soap preparations of ethanol extract of grapefruit peel (Citrus maxima) that can inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa bacteria. The method used is maceration by soaking simplisia in 96% ethanol for 1x24 hours then concentrated with a rotary evaporator and then evaporated with a watter bath. The finished extract was tested for phytochemical compounds of alkaloids, flavonoids, saponins and tannins. Then thin layer chromatography was carried out to emphasize flavonoid compounds. Then solid soap preparations were made with extract concentrations F1 5%, F2 7%, and F3 9%, then preparation evaluations were carried out such as organoleptic tests, homogeneity, pH, foam stability and cleaning power. After that, the antibacterial test was carried out using the disc method. The results of the diameter of the inhibition zone of the best Staphylococcus aureus antibacterial test were F3 9% concentration, which was 2.6 cm. While for Pseudomonas aeruginosa bacteria with 9% F3 concentration is also the best with an inhibition zone diameter of 1.3cm.
Efektivitas Antibakteri Ekstrak Jamur Endofit BS pada Media Tumbuh Beras Merah Pramesti, Radia Sagita; Iryani, Iryani; Ulfah, Mariam
Periodic Vol 13, No 1 (2024): PERIODIC
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/periodic.v13i1.119654

Abstract

BS endophytic fungus is a fungus isolated from the flower of the bitter plant (A. paniculata) which is known to produce various secondary metabolites which are reported to have antibacterial bioactivity. The purpose of this study was to determine the antibacterial activity of the extract of the endophytic fungus BS isolated from the bitter flower (A. paniculata) on brown rice growing media against Streptococcus mutans, Staphylococcus aureus, and Pseudomonas aeruginosa bacteria. BS endophytic fungi were grown on brown rice media and then extracted by maceration method with ethyl acetate as solvent. The antibacterial activity test of the extract was carried out by disc diffusion method. The results showed that BS endophytic mushroom extract grown on brown rice media could inhibit the growth of Streptococcus mutans, Staphylococcus aureus, and Pseudomonas aeruginosa bacteria at concentrations of 10%, 30%, and 50%. In conclusion, BS endophytic fungus isolated from A. paniculata flower can inhibit the growth of bacteria with the smallest diameter inhibitors successively on Staphylococcus aureus, Streptococcus mutans, Pseudomonas aeruginosa bacteria
Co-Authors Ade Irawan Adriani , Dhiva Alfayyasy, Akhmad Irfan Anshar Al Khairi, Varel Ayu Puspitasari, Ayu Ayu Syarifah, Nyimas Carissa Azachra, Akmevi Difta Rahmatika, Siti Efirani, Like Efriani, Like Faaizah, Adinda Fadillah, Aulia Nur Indri Hadi, Ismanurrahman Haq, Mailatul Ilal Iryani Iryani Lestary, Desy Mansor, Khaeron Nesta, Nesta oliviana, Resya Permatasari, Nova Pramesti, Radia Sagita Prihatiningsih, Sherly Purnama, Muhamad Rifki Putra, Teguh Adiyas Rahmatika, Siti Difta Riga, Riga Rizki, Kiki Nur Silviyani, Amerta Sri Benti Etika Suryelita, Suryelita Widayanti, Wiwin Yulianti, Dara Puspita Zahrotun Nisa, Zahrotun