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Identification of Prednison and Methyl Prednisolon in Weight-Gain Jamu from Online Marketplace Using TLC-Densitometry Method Fatmawati, Sofia; Siregar, Mirawati; Ananta, Lastri; Adjie, Sundari Kusuma
Jurnal Ilmu Kesehatan Vol 12 No 1 (2024): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar

Jamu or traditional medicine is an ingredient or mixture of ingredients derived from plant ingredients, animal ingredients, mineral ingredients, extract preparations (galenic), or a combination of these ingredients which have been used for generations for healing based on experience. Weight-gain jamu is a traditional medicine which is useful for increasing appetite and body weight. The product is widely used today and marketed through online platforms. This study aims to determine the corticosteroids Prednisone and Methyl Prednisolone that are present in weight-gain jamu using the TLC-Densitometry method. This study used 10 samples of weight-gain jamu purchased from the Shopee e-marketplace with inclusive criteria. Silica Gel GF 254 nm was used as the stationary phase. The mobile phases used are chloroform: ethyl acetate (1:9) for prednisone and water-saturated butanol: toluene: ether (5:10:85) for methyl prednisolone. Spiked samples were performed for confirmation of method validation. The results of this research showed that 2 jamu samples contained prednisone at 247 nm wavelength, and no jamu samples were positive for methyl prednisolone. This method could be applied to detect corticosteroids such as prednisone and methyl prednisolone in weight gain herbal medicine.

Identification of Prednison and Methyl Prednisolon in Weight-Gain Jamu from Online Marketplace Using TLC-Densitometry Method Fatmawati, Sofia; Siregar, Mirawati; Ananta, Lastri; Adjie, Sundari Kusuma
Jurnal Ilmu Kesehatan Vol 12 No 1 (2024): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar

Jamu or traditional medicine is an ingredient or mixture of ingredients derived from plant ingredients, animal ingredients, mineral ingredients, extract preparations (galenic), or a combination of these ingredients which have been used for generations for healing based on experience. Weight-gain jamu is a traditional medicine which is useful for increasing appetite and body weight. The product is widely used today and marketed through online platforms. This study aims to determine the corticosteroids Prednisone and Methyl Prednisolone that are present in weight-gain jamu using the TLC-Densitometry method. This study used 10 samples of weight-gain jamu purchased from the Shopee e-marketplace with inclusive criteria. Silica Gel GF 254 nm was used as the stationary phase. The mobile phases used are chloroform: ethyl acetate (1:9) for prednisone and water-saturated butanol: toluene: ether (5:10:85) for methyl prednisolone. Spiked samples were performed for confirmation of method validation. The results of this research showed that 2 jamu samples contained prednisone at 247 nm wavelength, and no jamu samples were positive for methyl prednisolone. This method could be applied to detect corticosteroids such as prednisone and methyl prednisolone in weight gain herbal medicine.

Edukasi, Budidaya dan Pemanfaatan Tanaman Obat yang Berada di Sekitar Kita: Education, Cultivation and Utilization of Medicinal Plants that are Around Us Siregar, Mirawati; Pahriyani, Ani; Sulistyaningsih, Endang
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 10 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i10.7619

Green meniran plants and Chinese betel leaves are medicinal plants that are widely used by the community. This activity aims to educate the public regarding the correct use of medicinal plants, their benefits, processing, and cultivation methods. The training implementation method is carried out by providing counseling and direct observation of sample plants and how they are processed. To measure success, namely collecting pre-test and post-test data, allowing researchers to measure participants' knowledge before and after health education. The results of the activity show that the level of knowledge of the elderly increased after taking part in the event as seen from the results of the correct scores on the post-test. The participants' knowledge increased because apart from providing education in the form of counseling, it was accompanied by direct identification of plants from samples provided by the team.

Pendampingan self-management diabetes dan hipertensi bagi lansia melalui edukasi dan games Pahriyani, Ani; Sulistaningsih, Endang; Siregar, Mirawati
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 6 No 1 (2023)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v6i1.19568

Kegiatan Program Kemitraan Masyarakat ini bertemakan Penguatan Self-Management Diabetes dan Hipertensi melalui edukasi dan Games di Muhammadiyah Senior Care Rumah Sakit Islam Jakarta Sukapura dengan sasaran lansia tergabung dalam Muhammadiyah Senior Care (MSC) RS Islam Jakarta Sukapura Jakarta Utara. Tema ini dipilih karena salah satu cara yang efektif dalam penguatan self-management untuk penyakit menahun yang banyak diderita oleh para lansia adalah pengobatan secara paliatif yang diharapkan dapat meningkatkan kualitas hidup pasien. Metode penyuluhan ini menggunakan metode Asset Based Communities Development (ABCD) melalui edukasi dan permainan yang dapat merangsang otak dan meningkatkan semangat para lansia serta menambah pengetahuan pasien. Materi edukasi disampaikan langsung oleh dosen farmasi dalam tim pengabdian ini dan kompetensi baik dari sisi keilmuan maupun dasar-dasar penyuluhan yang disampaikan oleh dosen yang sekaligus praktisi kesehatan di Rumah Sakit. Hasil dari pelaksanaan kegiatan ini dapat dilihat dengan antusiasme peserta dalam kegiatan ini serta didukung dari hasil penyebaran kuesioner pengetahuan self-management diabetes dan hipertensi setelah kegiatan berlangsung diperoleh 52% peserta pengetahuannya dengan kategori baik, 32% kategori cukup dan 16% kategori kurang. Simpulan dari kegiatan ini bahwa penguatan self-management diabetes dan hipertensi memiliki kemanfaatan bagi masyarakat warga Muhammadiyah Senior Care RSIJ Sukapura.

Identification and Assay of Isoniazid and Pyrazinamide in Fixed-Dose Dispersible Tablets Containing Rifampicin Using High-Performance Liquid Chromatography Santikasari, Citra; Wulandari, Meyliana; Nafisa Ulfa, Shofi; Siregar, Mirawati; Sulaiman, Syed Azhar Syed
Jurnal Riset Sains dan Kimia Terapan Vol. 11 No. 2 (2025): Jurnal Riset Sains dan Kimia Terapan, Volume 11 Nomor 2, Desember 2025
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.112.04

Tuberculosis (TB) remains a major global health challenge, particularly in Indonesia, which ranks among the countries withthe highest TB burden. Fixed-dose dispersible anti-tuberculosis formulations containing rifampicin, isoniazid, and pyrazinamide are widely recommended to enhance patient adherence and minimize the risk of drug resistance. Ensuring the quality and appropriate dosage of active pharmaceutical ingredients is essential for achieving therapeutic effectiveness and maintaining TB control. This study aimed to perform routine quality assessment and regulatory compliance assays on commercialanti-TB fixed-dose combination (FDC) dispersible tablets using a reversed-phase high-performance liquid chromatography (HPLC) method as specified in the International Pharmacopoeia 2025. The HPLC system was equipped with a C18 column and used a mobile phase consisting of acetate buffer (pH 5) and methanol (94:6 v/v). System suitability testing was conducted before analysis, with %RSD values below 2%, resolution greaterthan 2.0, and tailing factors ≤ 2.0, indicating acceptable precision, selectivity, and chromatographic performance. The retention times of isoniazid and pyrazinamide were consistent with those of the reference standards, confirming identity. The assay results showed that pyrazinamide (100.3%) and isoniazid (99.9%) were within the specification limits set by the International Pharmacopoeia. These findings demonstrate that the official monograph method is suitable for regulatory-grade quality control testing of dispersible anti-tuberculosis fixed-dose combination tablets, and that the tested product met pharmacopeial quality requirements.

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