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Wardhana, M. Fitra
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Education Medicine & Pharmacology Neuroscience Public Health

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Perbandingan Efektivitas Obat Antihipertensi Golongan ARB versus CCB terhadap Penurunan Tekanan Darah pada Pasien Hipertensi Nuryanti, Eva; Wardhana, M. Fitra; Damayanti, Ervina; Triyandi, Ramadhan
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1047

Abstract

Hypertension is defined as a systolic blood pressure of more than 140 mmHg and a diastolic blood pressure of more than 90 mmHg. Hypertension is a degenerative disease that requires long-term treatment. Hypertension is a silent killer disease because it does not cause symptoms and is only detected during physical examination due to certain diseases so that it can be a major cause of morbidity and mortality. Hypertension management guidelines recommend the use of thiazide/ACEi/ARB/CCB diuretic class drug monotherapy. The purpose of this study is to determine the difference in effectiveness between Calcium Channel Blocker (CCB) and Angiostensin Receptor Blocker (ARB) antihypertensives in reducing blood pressure. The method used in this study is through literature review using a database through Google Schoolar and Pubmed with a time span of 2013-2023 using the PICO method with keywords or keywords tailored to the search topic and articles selected based on inclusion criteria. The results of the literature show that ARB and CCB antihypertensives have similar effectiveness in lowering blood pressure. CCB antihypertensives are vasculoselective. This can be beneficial because CCBs are able to reduce peripheral resistance without reducing heart function so as to reduce the incidence of stroke. However, the use of CCBs can cause edema while ARBs have renoprotective effects or effects that protect the kidneys.
Potensi Beberapa Tumbuhan Sebagai Anti Inflamasi di Indonesi Mutiara, Sephia Aruma; Damayanti, Ervina; Wardhana, M. Fitra; Sukohar, Asep
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1096

Abstract

Inflammation is a biological response of the immune system that can be triggered by various factor including pathogens, physical trauma and toxic compounds. Prolonged consumption of NSAID as an anti-inflammatory can caused some serious side effects for the body. As a result, many people has switched to using plants as therapy. Another reason for choosing therapy with plants is more affordable, as well as family traditions trust in the efficacy of a plant. The purpose of this review article is to provide information about several medicinal plants that have anti-inflammatory  activity. The method in this study was a systematic literature review which is traced through database, Google Scholar and Pubmed. The literature used was published in 2019 to 2024 and 11 journals were obtained as primary data. Some plants studied as anti-inflammatory are red spinach (Amarathus tricolor L.), Beligo (Benincasa hispida (Thunb.) Cogn.), Pineapple (Ananas Comosus (L.) Merr.), Kecapi (Sandoricum koetjape (Burm.f. ) Merr., Sesewanua (Clerodendrum squamatum Vahl.), Turmeric (Curcuma domestica Val.), Aloe vera (Aloe vera L), Tamarind (Tamarindus indica L.), Green grass jelly (Cyclea barbata Miers.) and Galangal (Kaempferia galangal L.). In research on the anti-inflammatory activity of several plants studied, it was proven to be able to improve several inflammatory parameters, but at different doses because it depended on the response of the test animals and the secondary metabolite content of each plant.
Co-Authors Asep Sukohar Damayanti, Ervina Mutiara, Sephia Aruma Nuryanti, Eva Triyandi, Ramadhan