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All Journal Dentino: Jurnal Kedokteran Gigi B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah
Santoso, Astrid Widhowaty
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Dentistry

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MANAGEMENT OF COATED TONGUE RESEMBLES PSEUDOMEMBRANOUS CANDIDIASIS IN A MULTIDRUG-THERAPY PATIENT Santoso, Astrid Widhowaty; T. Santo, Agustin Ninintowe; Setiadhi, Riani
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18863

Abstract

Introduction: Coated tongue or tongue coating is characterized by white deposit covering dorsum of the tongue. The thick-coated tongue almost resembles oral candidiasis. It is challenging to make the diagnosis and provide the proper treatment especially when supporting examination tools are unavailable. Objective: To discuss the diagnosis making and management of coated tongue with suspicion of pseudomembranous candidiasis with a lack of supporting examination tools. Case(s): A 61-year-old man was referred to the Oral Medicine Clinic for oral examination. No complaints of  pain in the oral cavity. He had a history of type-2 diabetes mellitus, coronary heart disease (CHD), and pleuritis and was taking medication. During hospitalization, never cleaned his oral cavity. Case Management: Intraorally, white plaque covering almost the entire dorsum of the tongue, which could be scraped off on the anterior 1/3 but not on the posterior 2/3. The diagnosis was suspected coated tongue with oral candidiasis as the differential diagnosis. The treatments were compressing the tongue using gauze soaked in 3% hydrogen peroxide (H2O2) solution, scrapping off using a tongue scraper, then rinsing with water. The thick-coated tongue can be easily removed. He was also given 0,2% chlorhexidine gluconate (CHX) mouthwash as an antiseptic and petroleum jelly for dry lips. The tongue condition improved on 2nd day therapy after rinsing regularly using 0,2% CHX. Conclusion: Recognizing the signs, symptoms, and associated factors of Candida infection is important. Coated tongue which resembles pseudomembranous candidiasis was successfully treated using 3% H2O2 compresses, tongue scraping, and 0.2% CHX mouthwash. Keywords: Chlorhexidine gluconate, Coated tongue, Hydrogen peroxide, Infection, Oral candidiasis
MATRIX METALOPROTEINASE AS A POTENTIAL SALIVARY BIOMARKER FOR ORAL SQUAMOUS CELL CARCINOMA Santoso, Astrid Widhowaty; Setiadhi, Riani
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 11, No 1 (2024): Vol 11 No 1, Juni 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v11i1.1470

Abstract

Introduction: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide and the most prevalent form of oral cancer. The five-year survival rate for OSCC varies considerably depending on the stage of the disease, ranging from 40% to 60%. The majority of cases are diagnosed at an advanced stage, resulting in a significantly reduced life expectancy. Therefore, there is a clear need for effective strategies to detect cancer at an early stage. Aim: The objective of this article is to identify the potential of matrix metalloproteinase (MMP) as a salivary biomarker for the early detection of oral squamous cell carcinoma (OSCC). Review: Saliva is considered a potential source of biomarkers for oral cancer due to its continuous contact with cancerous lesions in the oral cavity and the various enzymes, hormones, antibodies, antimicrobial constituents, and cytokines it contains. MMP is an extracellular endopeptidase enzyme present in saliva and associated with the carcinogenesis process. It has been identified as a salivary biomarker for the early detection of OSCC. The levels of several MMP proteins in the saliva of OSCC patients have been found to be elevated, including MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, and MMP-13. Conclusion: The increased levels of salivary MMP, which were most specifically found in OSCC patients, included MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-12, and MMP-13. This suggests that MMP may be a potential salivary biomarker for the early detection of OSCC
Co-Authors Riani Setiadhi T. Santo, Agustin Ninintowe