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All Journal Indonesian Journal of Tropical and Infectious Disease Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Berita Kedokteran Masyarakat
Unicha, Mutiara Shinta Noviar
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Earth & Planetary Sciences Health Professions Medicine & Pharmacology Nursing Public Health

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Novel Potential Immune Response Biomarkers to Multidrug-Resistant Tuberculosis in the Last Five Years Unicha, Mutiara Shinta Noviar; Wayan Tunas Artama; Niken Irfa Nastiti
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 1 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i1.32119

Abstract

Rapid and accurate detection performs an important role in the control of raising MDR-TB. Currently, studies on biomarkers as targets for TB diagnostic tests using immune response products to indicate the presence, mycobacterial load, early markers, and activity, diff erentiation, and progression markers of TB infection are rapidly available. This systematic review aims to summarize the last fi ve years of potential biomarkers studies from the immune response for MDR-TB rapid diagnostic development. The authors performed a literature search on four databases as ProQuest, EBSCO Academic Search, Universitas Gadjah Mada Online Library Journal Database, and Google Scholar, retrieved from January 2016 to December 2021. In total, 18,288 articles were identifi ed and three tudies met the inclusion criteria. Several promising biomarkers were found for MDR-TB diagnosis purposes, such as sCD14, PGLYRP2, FGA, Indoleamine 2, 3- dioxygenase (IDO), and Complement Receptor 2 (CR2). A combination of sCD14, PGLYRP2, and FGA were bringing a diagnostic design with a higher sensitivity (94.7%) and specifi city (80%) than the design of a single protein. Higher IDO activity towards the MDR-TB group than in the DS-TB group with a sensitivity of 87.50 %, specifi city of 72.22 %. CR2 was the main focus due to its association with IL-6. After induction of CR2 peptide in a dose-dependent manner, the expression level of IL-6 was decreased signifi cantly. It might because of CR2 peptide regulating the macrophages proinfl ammatory cytokines secretion to decrease the local infl ammation of the immune response. These biomarkers are strong candidates for MDR-TB diagnosis due to their important role as the pathogenesis marker of MDR-TB. There is a need of further research to investigate those immune response products and their role to eliminate infection of Mycobacterium tuberculosis directly.
The Disruptions-Related Tuberculosis Case Finding and Treatment in Indonesia during COVID-19 Unicha, Mutiara Shinta Noviar; Dwi Murdiati; Intan Wahyuni Tukiyo; Intan Pristian Yuliyani
Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Vol. 11 No. 2 (2023): Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Educatio
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpk.V11.I2.2023.127-132

Abstract

Background: This study aims to find out the disruptions related to the TB new case finding and treatment program during the COVID-19 pandemic in Indonesia. This understanding is needed to conceive effective strategies to face and prevent the issues of TB program implementation in health services and health care. Methods: This review used selected articles conducted in Indonesia, published during the COVID-19 pandemic from March 2020 to July 2022 from ScienceDirect, PubMed, ProQuest, and Google Scholar journal databases. Results: 7187 related studies were identified by the keywords. In the final process, there were 7 studies included in the review. The studies covered 5 provinces mentioned 3 cities and 2 regencies. The disruptions in TB new case finding and treatment health services were affected by participants' knowledge of the differences between TB and COVID-19, family support, family history of COVID-19, comorbidity, double workloads of the health workers, and accessibility of healthcare accommodation. New methods for new case findings and treatment adherence such as scheduled home visits, community-based finding health empowerment, the development of a new invention of eNose-TB, modification of the administration process, and the use of virtual care were implemented to overcome these issues during this pandemic. Conclusion: The majority of tuberculosis issues during COVID-19 were related to social determinants. The health empowerment that involved community and several modifications to health services were applied to healthcare as resolutions besides preserving the achievement of new case findings and treatment programs.
Zooprophylaxis implementation as malaria control program in rural areas in Indonesia: a systematic review Unicha, Mutiara Shinta Noviar; Nastiti, Niken Irfa; Purwanti, Eti; Murdiati, Dwi
BKM Public Health and Community Medicine PHS7 Accepted Abstracts
Publisher : Universitas Gadjah Mada

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Abstract

Objective: This study aims to review whether zooprophylaxis could be an effective prevention program for malaria infection in rural areas, required for its general implementations in Indonesia. Method: The words 'Zooprophylaxis' and 'malaria control' were searched by four electronic databases like ProQuest, EBSCO, Cochrane, and Universitas Gadjah Mada Library database. Only relevant articles which met the eligibility criteria were included in this systematic review. Critical appraisal using PRISMA 2009 and CONSORT 2010 checklist were applied for a full review by contributed authors. Results: The total of 647 articles were screened, and only 15 relevant articles were included in this study. Along with the use of household insecticides, Zooprophylaxis had been implemented in Banyumas Regency in Indonesia and proved to reduce the Man Bitting Rate (MBR) from 1,426 to 0,046. Only types of vector that have zoo-antrophylic bionomic that this program can control. The closer area of vector breeding sites with livestock to settlements plays an important role in the program's success. Also, the ecological-geographical conditions and the proportion of livestock-size could give a protective effect vice versa. Conclusion: Zooprophylaxis could be used effectively as a prevention program for malaria infection in rural areas by considering several conditions and mosquito bionomics. Coupled with the use of spray insecticides for night outdoor activities and bed-net for indoors and the application of ecological modification with the One Health approach, these could increase its effectiveness as a malaria control program in rural areas in Indonesia.
Co-Authors Dwi Murdiati Intan Pristian Yuliyani Intan Wahyuni Tukiyo Niken Irfa Nastiti Purwanti, Eti Wayan Tunas Artama