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All Journal International Journal of Electrical and Computer Engineering Journal of the Indonesian Mathematical Society Journal of Applied Pharmaceutical Research Indonesian Journal of Electrical Engineering and Computer Science
Sharma, Amit
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Computer Science & IT Electrical & Electronics Engineering Mathematics Medicine & Pharmacology

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Journal : Journal of Applied Pharmaceutical Research

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Cinnamomum impressinervium meisn.: antioxidant and antimicrobial activities Bhatia, Lovkesh; Sharma, Amit; Kalra, Rishu; Kumar, Varun
Journal of Applied Pharmaceutical Research Vol. 12 No. 1 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.1.100.107

Abstract

Background: The Cinnamomum impressinervium (CI) Meisn. Tree, which belongs to the Lauraceae family and is endemic to India, is also called Assameses or Tejiya. Numerous pharmacological properties of this plant, including anti-tumor, anti-inflammatory, and antioxidant properties, have been demonstrated. Materials and method: This study examines the phytochemical profile of the leaf using qualitative and quantitative methods. Following the phytochemical analysis of the leaf, the antioxidant efficacy for scavenging free radicals (ABTS and DPPH) was measured. Using the agar well diffusion method, the antibacterial potential of the crude extract and its fractions (aqueous, methanolic, n-hexane, and chloroform) was investigated against six gram-negative, three gram-positive, and one fungal strain. Result and discussion: Antioxidant activities of various extracts viz: aqueous, hexane, chloroform, and ethanol were prepared and subjected to antioxidant and antimicrobial activities. Through qualitative analysis, several alkaloids, steroids, and flavones were identified. In the DPPH and ABTS assays, the aqueous extract had the most potent antioxidant activity, with IC50 values of 123.83±0.42 and 57.86±0.85 μg/mL, respectively. DNA nicking assay is a qualitative analysis that shows DNA protection from free radicals. All the extracts towards B. atropheous showed best inhibition activity but a maximum zone of inhibition was shown by aqueous extracts measuring 40 mm. Aqueous and methanolic extracts are completely inactive towards S. typhi. Conclusion: This study revealed the antioxidant and antimicrobial efficacy of various extracts of Cinnamomum impressinervium Meisn. Leaves In this paper, the antibacterial activity of leaf extracts from Cinnamomum impressinervium Meisn. were studied. The evaluated extracts showed varied levels of inhibitory zones against every tested bacterium.
Assessment of hepatoprotective and nephroprotective effects of Vitis vinifera leaf extract on carbon tetrachloride induced toxicity in rats Kumar, Ashok; Pragi; Sharma, Amit; Kumar, Varun
Journal of Applied Pharmaceutical Research Vol. 12 No. 1 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2024.12.1.82.92

Abstract

Background: Vitis vinifera is known for its antimicrobial activity; however, the hepatoprotective activity of aqueous extracts of aerial parts has also been reported, but the nephroprotective and hepatoprotective activity of ethanolic extracts have not yet been evaluated. Objective: To evaluate Vitis vinifera's hepatoprotective and nephroprotective activities against CCl4-induced toxicity in rats. Methods: Two doses of ethanolic extract of Vitis vinifera (100 and 200 mg/kg/day) were evaluated and compared with silymarin 100 mg/kg. Biochemical blood parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Gamma-glutamyltranspeptidase (GGT), bilirubin, urea, uric acid, total protein and creatinine, and histopathologic changes of liver and kidney were studied and evaluated. Results: Vitis vinifera reduced the elevated blood levels of ALT, AST, ALP, urea, and creatinine, with the ethanol extract to 200 mg/kg/day being more effective. The histopathologic evaluation suggested that Vitis vinifera decreased hepatic and renal necrosis induced by CCl4. The more significant dose resulted in reductions in AST, ALT, GGT, ALP, and bilirubin of 54, 27, 56, 36, and 17%, respectively. Ethanolic extract 200 mg/kg/day also shows a reduction in elevated levels of Creatinine, Urea, Uric Acid, and Total Protein by 61%, 58%, 29%, and 9%, respectively. Conclusion: Hepatoprotective and nephroprotective activities of ethanol extract of Vitis vinifera were demonstrated, with ethanol extract to 200 mg/kg/day being the most effective. This presents scientific evidence for using medicinal plants such as Vitis vinifera in managing liver and kidney disorders.
Evaluation of the hepatoprotective and nephroprotective properties of bael fruit extract against carbon tetrachloride-induced toxicity in rats Garg, Deepak; Sharma, Amit; Pragi; Kumar , Varun
Journal of Applied Pharmaceutical Research Vol. 12 No. 3 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v12i3.524

Abstract

Background: Bael is well-known for its antibacterial properties. Aqueous fruit extracts have also been shown to have hepatoprotective properties; the nephroprotective and hepatoprotective properties of Ethanolic extracts have not yet been tested. Objective: To evaluate the hepatoprotective and nephroprotective activities of Bael against CCl4-induced toxicity in rats. Methods: Two dosages of Bael's Ethanolic extract (100 and 200 mg/kg/day) were compared with 100 mg/kg of silymarin. Histopathologic alterations of the liver and kidney, as well as biochemical blood parameters such as bilirubin, urea, uric acid, total protein and creatinine, alkaline phosphatase (ALP), alanine aminotransferase (ALT), were examined and assessed. Results: Bael was more successful in lowering high levels of urea, creatinine, ALT, AST, and ALP when he used a 200 mg/kg/day methanol extract. According to the histopathologic assessment, Bael lessened the CCl4-induced hepatic and renal necrosis. The more significant dose resulted in reductions in AST, ALT, GGT, ALP, and bilirubin of 45,25, 52,36, and 16%, respectively. Ethanolic extract 200 mg/kg/day also shows a reduction in elevated levels of Creatinine, Urea, Uric Acid, and Total Protein by 57%, 52%, 34%, and 9%, respectively. Conclusion: There were established hepatoprotective and nephroprotective effects of the Bael fruit methanol extract, with 200 mg/kg/day being the most beneficial dose. This provides scientific proof that medicinal herbs like Bael can be used to treat renal and liver diseases.
Novel coumarin chalcone derivatives: synthesis, docking, and antimicrobial evaluation Kumari, Sumita; Sharma, Amit; Yadav, Sonia
Journal of Applied Pharmaceutical Research Vol. 13 No. 1 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i1.838

Abstract

Background: This study synthesized and evaluated a series of coumarin chalcones for their antimicrobial efficacy against microbial and fungal strains. Methodology: Ten new coumarin chalcones were prepared by Claisen- Schmidt condensation by using 4-hydroxy coumarin as a precursor and followed by refluxing obtained intermediate (3-(4-aminophenyl)-3-oxo prop-1-enyl)-4-hydroxy-2H-chromen-one) with substituted aromatic benzaldehyde in the presence of piperidine as a catalyst. IR, 1HNMR, 13CNMR, and GCMS characterized all synthesized compounds. The agar well diffusion method assessed these compounds for antimicrobial activity against various bacterial and fungal strains such as E. coli, P. aeruginosa, B. subtills, S. aureus, and C. albicans. Zone inhibition was measured for each compound (10µL) against all strains. Results and Discussion: The study showed that derivatives 4c, 4e, 4f, and 4g showed strong potential for inhibition towards various fungal and microbial strains. The inhibition zone for 4c and 4e was emerged as 5.48±0.448, 7.02±0.332, 5.62±0.321, 6.81±0.021, 7.72±0.421 and 5.13±0.179, 6.76±0.511, 4.24±0.273, 4.64±0.231, 5.48±0.049 while compound 4f and 4g showed 5.40±0.420, 6.69±0.168, 5.71±0.245, 5.28±0.042, 7.09±0.175, and 4.94±0.814, 6.58±.0160, 6.01±0.455, 6.61±0.021, 6.91±0.414 mm, respectively. Between -7.1 to -10.2Kcal/mol is the range of docking score of derivatives by interactions of DNA gyrase and compounds analyzed. Here, compound 4g exhibited the highest DNA gyrase inhibition, and compound 4c exhibited a strong inhibition with docking scores of -10.2 kcal/mol and -9.8 kcal/mol, respectively. Conclusion: The findings of this work contribute to a better understanding the potential of synthesised compounds as drug candidate against microbial infections through ADMET study.
Co-Authors Awasthi, Mukesh Bhatia, Lovkesh Garg, Deepak Gupta, Indrajeet Jain, Parita Kalra, Rishu Kaur, Gagandeep Kumar , Varun Kumar, Ashok Kumar, Sandeep Kumar, Varun Kumari, Sumita Mani, Naveen Mathur, Vidhu Pragi Shokeen, Vikrant Shukla, Rahul Yadav, Sonia