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All Journal Jurnal Locus Penelitian dan Pengabdian GANESHA MEDICINA
Wiratama, Bayu Kresna
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Aerospace Engineering Automotive Engineering Decision Sciences, Operations Research & Management Electrical & Electronics Engineering Health Professions Mathematics Medicine & Pharmacology Public Health

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NYERI KEPALA SENTINEL PADA PERDARAHAN SUBARAKHNOID Wiratama, Bayu Kresna; Kamelia, Luh Putu Lina; Kesanda, I Made Phala; Agustini, Ni Nyoman Mestri; Kapakisan T., I Ketut S.
Ganesha Medicina Vol. 3 No. 2 (2023)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/gm.v3i2.69356

Abstract

Perdarahan Subarakhnoid (PSA) adalah kondisi perdarahan pada area subarakhnoid yang terletak pada otak. Gejala umum yang dirasakan pasien dan merupakan ciri khas gejala PSA adalah thunderclap headache yang muncul dengan onset mendadak dan mencapai intensitas nyeri maksimum dalam hitungan detik hingga menit namun tidak sedikit pula pasien mengalami nyeri kepala sentinel sebagai penanda awal PSA. Pasien perempuan 52 tahun dikeluhkan keluarganya mengalami kesadaran menurun ±30 menit disertai dengan ditemukannya muntah makanan. Setelah sadar pasien mengeluhkan pusing sejak ±20 hari sebelum masuk rumah sakit yang semakin memberat setiap harinya dan hari ini tiba – tiba memuncak dalam waktu singkat. Pada pemeriksaan CT-Scan didapatkan Saccular Aneurysm di ICA/PCoA Junction sisi kiri dengan tanda rupture pada sisi inferior. Terapi yang diberikan berupa loading 300 cc Normal Saline 0,9%, Manitol 200 cc yang dilanjutkan 100 cc sebanyak 6x tapering off, Asam Tranexamat 3x1 gram, Dexamethasone 2x5 mg intravena, Pantoprazole 2x40 mg intravena, Paracetamol 1gr@6 jam intravena, Nimodipin 2.2 cc/jam dan pasien dirawat di ruang ICU selama 5 hari dan dilanjutkan perawatan di HCU Stroke Unit RSUD Kabupaten Buleleng selama 5 hari,
Vitamin D As Predictive Biomarker In The Severity of Acne Vulgaris: A Systematic Review Dewi, Merly Purnama; Sari, Ida Ayu Diah Purnama; Wiratama, Bayu Kresna; Rahmayani , Irma
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 1 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i1.5065

Abstract

This systematic review aims to evaluate differences in serum vitamin D levels between individuals with acne vulgaris and healthy individuals and to assess whether vitamin D levels can serve as a predictive biomarker for the severity of acne vulgaris. A systematic search was conducted using Publish or Perish, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, in Scopus, PubMed, Semantic Scholar, and SINTA databases. Eligible studies involved participants aged 12–59 years from Asia and Africa. Nine studies met the criteria, including 1,212 participants (655 with acne vulgaris and 557 healthy controls). The methodological quality of each included study was assessed using the Newcastle-Ottawa Scale (NOS), covering selection, comparability, and outcome domains. Most studies reported lower serum vitamin D levels in acne patients than in controls. Six studies showed a significant inverse correlation with acne severity, while three found no significant correlation, possibly due to influencing factors such as sun exposure, diet, supplements, and lifestyle. Although most studies indicate a significant inverse relationship between serum vitamin D levels and acne severity, the absence of predictive models and statistical validation prevents vitamin D from being established as a clinical predictive biomarker. Further prospective research employing validated predictive tools is required to confirm its role in acne management.
Co-Authors Dewi, Merly Purnama Kamelia, Luh Putu Lina Kapakisan T., I Ketut S. Kesanda, I Made Phala Ni Nyoman Mestri Agustini Rahmayani , Irma Sari, Ida Ayu Diah Purnama