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All Journal JURNAL FARMASIMED (JFM) Jurnal Pengabdian Masyarakat Putri Hijau
Evi Depiana
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Formulation Combination Of Kecombrang (Etlingera elatior) Leaf Extract And Papaya Leaves (Carica papaya L.) As Antidiabetes Simorangkir, Delisma Marsauli; Linta Meliala; Masria Sianipar; Evi Depiana; Ella Pratiwi
Jurnal FARMASIMED (JFM) Vol 6 No 2 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v6i2.1935

Abstract

Diabetes imellitus iis ia ichronic imetabolic idisease icharacterized iby iincreased iblood iglucose ilevels ithat ican ibe itreated iwith itraditional imedicine iderived ifrom iplants. iOne iexample iof iplants ithat ican ireduce iblood iglucose ilevels iis ikecombrang ileaves iand ipapaya ileaves iwhich icontain iflavonoids. iThe ipurpose iof ithis istudy iwas ito idetermine ithe ieffect iof icapsule iadministration iof ia icombination iof ikecombrang ileaf iextract iand ipapaya ileaf iextract iin ireducing iblood iglucose ilevels icompared iwith iglibenclamide. iThe istudy iused i24 irats iinduced iby ialloxan iand idivided iinto i8 igroups that is i icapsule ibase,i iglibenclamide idose i0.45 img/kgBB (positive icontrol), ikecombrang iextract icapsules idose i100 img/kgBB, ipapaya iextract icapsules idose i200 img/kgBB, icombination iof ikecombrang iextract icapsules idose i50 img/kgBB iand ipapaya iextract icapsules idose i100 img/kgBB, icombination iof ikecombrang iextract icapsules idose i50 img/kgBB iand ipapaya iextract icapsules idose i200 img/kgBB, icombination iof ikecombrang iextract icapsules idose i100 img/kgBB iand ipapaya iextract icapsules idose i100 img/kgBB, iand icombination iof ikecombrang iextract icapsules idose i100 img/kgBB iand ipapaya iextract icapsules idose i200 img/kgBB. iData iwere istatistically ianalyzed iusing iOne iWay iAnova. iThe iresults iof idata ianalysis iof iall itreatment igroups ihave ian ieffect ion ireducing iblood isugar ilevels ibecause ithe isig ivalue i<0.05 iexcept ithe inegative icontrol igroup. iBased ion iOne iWay iAnova ianalysis iof ithe ieight imost ieffective itreatments iis ithe icontrol igroup iwith iglibenclamide iadministration, then followed by the combination group of kecombrang leaf extract capsules at a dose of 100mg / kgBB and papaya leaf extract 200mg / kgBB.
The Effect of Laban Leaf Ethanol Extract Cream (Vitex pinnata) on Wound Healing on Male White Rats (Rattus norvegicus) Wistar Strain Simorangkir, Delisma Marsauli; Evi Depiana; Masria Sianipar; Chindy Umaya; Gratia Apulina
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2713

Abstract

Wound healing is a process that involves the restoration of injured or dead tissue and replacing it with new tissue through the process of cell regeneration. Although the wounds that occur tend to be mild, they need to be treated immediately to avoid infection that will hinder the healing process, even causing dangerous diseases. Therefore, natural product-based treatments have been explored naturally because of their ability to provide optimal wound healing effects to patients such as laban leaves (Vitex pinnata). The method used in this study was a laboratory experiment that began with the manufacture of extracts, cream formulations, and testing of wound healing activity. The test animals, male white rats of the Wistar strain, were divided into 5 groups for different treatments. Wound healing activity was measured by observing the diameter of the wound and healing time, and analyzed statistically using the One Way Anova method. The results showed that the preparation of ethanol extract cream of laban leaves (Vitex pinnata) was effective in accelerating the healing of cuts in male white rats at a concentration of 25% which was almost the same as the positive control. The conclusion of this study shows that the ethanol extract of laban leaves (Vitex pinnata) can be formulated into an effective cream preparation for wound healing, with a concentration of 25% as the most optimal concentration.
FORMULASI SEDIAAN LILIN EKSTRAK MINYAK ATSIRI BUNGA SEDAP MALAM (Polianthes tuberosa ) SEBAGAI AROMATERAPI TIO RANTI SARI SEMBIRING; Evi Depiana
Jurnal Pengabdian Masyarakat Putri Hijau Vol. 6 No. 3 (2026): Jurnal Pengabdian Masyarakat Putri Hijau (JPMPH)
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v6i3.3096

Abstract

This study aims to formulate and evaluate aromatherapy wax preparations from nightshade flower essential oil extract (Polianthes tuberosa) as an effort to handle non-pharmacological stress. The essential oil of the nightshade flower is obtained through the method of steam distillation from 10 kg of fresh flowers, resulting in 30 ml of essential oil. The characterization of simplicia showed a moisture content of 5.71%, a water soluble cider content of 17.13%, an ethanol soluble cider content of 18.01%, a total ash content of 10.82%, and an acid-insoluble ash content of 1.49%, meeting the requirements of the Indonesian Herbal Pharmacopoeia. Phytochemical screening identifies alkaloids, flavonoids, tannins, saponins, triterpenoids, and glycosides. Aromatherapy candles are formulated in four variations of essential oil concentrations (Polianthes tuberosa): 0% (F0), 5% (F1), 10% (F2), and 15% (F3), as well as one positive control (F4). Physical evaluation shows all formulas have a good, dense, and air bubble-free appearance. The hedonic test showed that the F3 formula (15% essential oil) was preferred by the panelists in terms of aroma, shape, and color, and provided a significant relaxation and refreshment effect, close to the quality of commercial products. The F3's burn time reaches 10 hours, showing good durability.
Co-Authors Chindy Umaya Delisma Marsauli Simorangkir Ella Pratiwi Gratia Apulina Linta Meliala Masria Sianipar Tio Ranti Sari Br Sembiring