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All Journal JBIO: jurnal biosains (the journal of biosciences) JURNAL FARMASIMED (JFM) Jurnal Penelitian Farmasi dan Herbal Jurnal Pengabdian Masyarakat Putri Hijau
Simorangkir, Delisma Marsauli
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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SOSIALISASI EDUKASI PENGGUNAAN VITAMIN NEUROTROPIK BAGI MASYARAKAT DESA KWALA SIMEME KECAMATAN NAMORAMBE Simorangkir, Delisma Marsauli
Jurnal Pengabdian Masyarakat Putri Hijau Vol 5 No 3 (2025): Jurnal Pengabdian Masyarakat Putri Hijau (JPMPH)
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpmph.v5i3.2437

Abstract

This Community Service Activity aims to socialize the pharmacist profession and educate the people of Kwala Sime Village, Namorambe District. Neuropathy is a condition that requires serious attention, and early treatment is essential to improve the patient's quality of life. Education about neuropathy and the use of B complex vitamins, consisting of vitamins B1, B6, and B12, is expected to increase public awareness of the importance of treating this disease. This activity involved students of the Pharmacist Professional Study Program of the Deli Husada Deli Tua Health Institute as extension workers, and was held on May 6, 2025. The results of this activity show an increase in public understanding of the role of pharmacists and the benefits of neurotrophic vitamins, as well as encouraging people to pay more attention to their neural health. This activity is expected to continue to provide further education to the community.
The Effect of Laban Leaf Ethanol Extract Cream (Vitex pinnata) on Wound Healing on Male White Rats (Rattus norvegicus) Wistar Strain Simorangkir, Delisma Marsauli; Evi Depiana; Masria Sianipar; Chindy Umaya; Gratia Apulina
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2713

Abstract

Wound healing is a process that involves the restoration of injured or dead tissue and replacing it with new tissue through the process of cell regeneration. Although the wounds that occur tend to be mild, they need to be treated immediately to avoid infection that will hinder the healing process, even causing dangerous diseases. Therefore, natural product-based treatments have been explored naturally because of their ability to provide optimal wound healing effects to patients such as laban leaves (Vitex pinnata). The method used in this study was a laboratory experiment that began with the manufacture of extracts, cream formulations, and testing of wound healing activity. The test animals, male white rats of the Wistar strain, were divided into 5 groups for different treatments. Wound healing activity was measured by observing the diameter of the wound and healing time, and analyzed statistically using the One Way Anova method. The results showed that the preparation of ethanol extract cream of laban leaves (Vitex pinnata) was effective in accelerating the healing of cuts in male white rats at a concentration of 25% which was almost the same as the positive control. The conclusion of this study shows that the ethanol extract of laban leaves (Vitex pinnata) can be formulated into an effective cream preparation for wound healing, with a concentration of 25% as the most optimal concentration.
Antibacterial Activity Test of Breadfulness Leaf Extract Plaster Preparation ( Artocarpus altilis ) In Vitro and In Vivo In The Treatment of Mice Cut Wounds Simorangkir, Delisma Marsauli
JURNAL BIOSAINS Vol. 11 No. 1 (2025): JURNAL BIOSAINS
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v11i1.64636

Abstract

The skin is the largest organ in the human body. One of the problems that often occurs in the skin is wounds. Wounds are damage or loss of tissue in the body caused by a factor, one type of wound is a cut wound. Cuts occur due to friction with objects causing linear tears in the skin and underlying tissue. Cuts can cause infections due to bacteria. Breadfruit leaves (Artocarpus altilis) contain flavonoid compounds that can regenerate the skin by increasing collagen in the skin and have bactericidal properties. This study aims to determine the optimal concentration in the activity of breadfruit leaf extract formulated in the form of plasters against in vitro and in vivo tests in the treatment of cut wounds in mice. This study used the maceration method in making the extract using 96% ethanol solvent. Breadfruit leaf extract was formulated into a plaster preparation with various concentrations F1: EEDS 10%, F2: EEDS 15%, F3: EEDS 20%, and F4: EEDS 25%. The plaster preparation was evaluated to determine the physical properties and compounds of the wound dressing material by conducting thickness tests, humidity tests, pH tests, organoleptic tests, FTIR tests, activity tests of the preparation against in vitro tests and in vivo tests. The results showed that the concentration of EEDS 25% with a value of 24.35 against the in vitro test using Staphylococcus aureus bacteria with a Hansaplast plaster comparator with a value of 16.35. In the in vitro test in the treatment of mouse cuts, it was stated that the concentration of EEDS 25% with a healing day of 10.6 days was close to the healing day of the Hansaplast plaster comparator with a healing day of 9.3 days.
FORMULASI SEDIAAN GEL EKSTRAK ETANOL DAUN BIDARA (Ziziphus mauritiana L) SEBAGAI PENYEMBUHAN LUKA BAKAR TERHADAP TIKUS PUTIH JANTAN Simorangkir, Delisma Marsauli
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2266

Abstract

Burn wound treatment is still carried out simply and is generalized with a certain pattern for various wound conditions and problems. One of the natural ingredients (herbs) that has an effect as a medicine for burns is the Bidara plant (Zizipus mauritiana L.), which has antibacterial, anti-viral, antiseptic properties and its function in regenerating and repairing skin cells. This research is a type of experimental research. Sampling was carried out purposively. The research procedure consisted of several stages, namely making reagents, phytochemical screening tests, and examining the characteristics of the ethanol extract. The research procedure consisted of several stages, namely making reagents, phytochemical screening tests, and examining the characteristics of the ethanol extract. The results of microscopic examination of sapodilla leaf simplicia powder showed the presence of stomata, tissue cells, parenchymal tissue and normal hair. In the One Way Anova results table for total burn wound healing after treatment, it shows a sig value <0.05 with the burn wound healing value from day 1 showing a significant value: 0.000. This shows that there is a significant difference in the value of burn wound healing from day 1. 1st to 14th day. The identification results of Bidara leaf extract (Zizipus mauritiana L.) showed that it positively contained secondary metabolite compounds, namely alkaloid compounds, flavonoid compounds, tannin compounds, saponin compounds and terpenoid compounds. The ethanol extract gel preparation of bidara leaves is less effective than bioplacenton for healing burns.
FORMULASI DAN UJI KETAHANAN SEDIAAN PARFUM SPRAY BUNGA LILI ( Lilium longiflorum) Simorangkir, Delisma Marsauli
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2704

Abstract

This study aimed to formulate and evaluate the fragrance longevity of lily flower (Lilium longiflorum) spray perfume. Lily essential oil was extracted using steam distillation and formulated at concentrations of 5%, 10%, and 15% with additional fixatives, solvents, solubilizers, and preservatives. Evaluations included organoleptic tests, density, pH, fragrance longevity, stability, and aroma preference. Results showed that all formulations had good clarity, homogeneity, and skin-safe pH values (5.29–5.55). Formula 2 (10%) provided the best balanced fragrance intensity and received the highest preference score from panelists. The longest fragrance retention was achieved by Formula 3 (15%), though its intensity was considered too strong. In conclusion, lily essential oil spray perfume can be formulated stably with adequate fragrance longevity, showing potential as a competitive natural perfume product.
“UJI EFEKTIVITAS FORMULASI EKSTRAK ETANOL BUAH PARE (Momordica charantia L.) DENGAN DAUN PEPAYA (Carica Papaya L.) SEBAGAI LOTION AEDES AEGYPTI” SEMBIRING, TIO RANTI SARI; Simorangkir, Delisma Marsauli
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2734

Abstract

Flaviviridae, genus Flavivirus, and group of arthropod-borne viruses. Aedes mosquitoes, particularly Aedes aegypti or Aedes albopictus, are the primary vectors of dengue disease transmission. A product that is used in skin-protection cosmetics to protect the skin from mosquito bites is anti-mosquito lotion (repellent). Water, emulsifying agents, humectants, and fatty ingredients make up lotion preparations. The bitter gourd and papaya leaves employed in this study were the active ingredients used to make lotion preparations. The lotion formulation used in this investigation contained flavonoid chemicals at varied extract concentrations of 0%, 2%, 4%, and 6%. The bitter gourd's and leaves' active components Because papaya is known to contain a lot of antioxidants, it can be used as an insecticide and lotion to ward against mosquitoes. According to SNI-16-4399-1996, preparations for anti-mosquito lotion made from papaya leaves and bitter melon extract pass the physical quality test because they are all homogeneous, have an oil-in-water emulsion type, are stable during storage for two weeks, and do not irritate the skin. Anti-mosquito lotion made with bitter melon fruit extract and papaya leaves, which is distinguished by the presence of dead mosquitoes in each formulation, has an effect on the effectiveness as an insecticide or repellent against mosquitoes on the skin that is applied. The extract lotion preparations' concentration The most powerful insecticide or mosquito repellant is a 6% extract of bitter gourd fruit and papaya leaves.
Co-Authors Chindy Umaya Evi Depiana Gratia Apulina Masria Sianipar SEMBIRING, TIO RANTI SARI