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All Journal INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Health Information : Jurnal Penelitian
Pelu, Jusni Ekasari
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Podocalyxin Urine sebagai Biomarker Prediktor Nefropati Diabetik Orno, Theosobia Grace; Pelu, Jusni Ekasari
Health Information : Jurnal Penelitian Vol 15 No 2 (2023): Mei-Agustus
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v15i2.859

Abstract

Diabetes melitus tipe 2 (DMT2) merupakan penyebab terbanyak dari diabetes, terdiri atas sekitar 85% kasus. Nefropati Diabetik (ND) merupakan salah satu komplikasi dari penyakit diabetes melitus yang dapat berakhir sebagai gagal ginjal. Podocalyxin (PDX) merupakan protein yang diekspresikan dalam podosit ginjal yang berperan dalam menjaga struktur glomeruli. Desain penelitian ini dilakukan dengan metode observasional analitik dengan desain cross sectional. Jumlah sampel sebanyak 25 subjek DMT2 dengan ND dan 25 subjek DMT2 tanpa ND yang diperoleh dengan teknik sampling probability purposive sampling. Penelitian ini dilakukan di Poliklinik Endokrin, Laboratorium Patologi Klinik, Laboratorium Hasanuddin University Medical Research Center (HUM-RC) Rumah Sakit Universitas Hasanuddin Makassar. Subjek DMT2 dengan dan tanpa ND dikategorikan berdasarkan kadar Albumin/Creatinine Ratio (ACR) yang diukur menggunakan metode imunoturbidimetri dan kadar podocalyxin urine diukur menggunakan metode Enzyme-linked Immunosorbent Assay. Hasil penelitian menunjukkan Area Under Curve validitas PDX terukur pada 0,779 dengan derajat kepercayaan 0,685-0,913 (p<0,05). Nilai cut off point sebesar 0,175 ng/mL dengan sensitivitas sebesar 66,7%, spesifisitas sebesar 64,3%. Disimpulkan bahwa PDX dengan nilai kadar 0,175 ng/mL dapat digunakan sebagai biomarker prediktor ND.
Analysis of Urine Podocalyxin in Type 2 Diabetes Mellitus Subjects With and Without Diabetic Nephropathy Pelu, Jusni Ekasari; Kurniawan, Liong Boy; Widaningsih, Yuyun; Zainuddin, Alfian; Umar, Husaini; Nurahmi, Nurahmi; Orno, Theosobia Grace
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 5 No 1 (2023): Step up to strengthen the laboratory system and prepare for patients care
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v5i1.3933

Abstract

Type 2 diabetes mellitus is the most common cause of diabetes, consist from about 85% of cases. Diabetic nephropathy is a complication of diabetes mellitus in the kidneys which can end up as kidney failure. Podocalyxin (PDX) is a protein expressed in kidney podocytes that is involved in various cancers, and is also essential for kidney development. The research design was carried out using observational and cross-sectional analytic methods with total participants of 25 DM with diabetic nephropathy and 25 DM without diabetic nephropathy with a purposive probability sampling technique. This research conducted at the Endocrine Polyclinic, Clinical Pathology Laboratory, Hasanuddin University Medical Research Center (HUM-RC) Laboratory, Hasanuddin University Hospital, Makassar. The results showed that the urinary PDX level in DM subjects with nephropathy were 1.160 ng/mL and DM without nephropathy were 0.167 ng/mL (p<0.001), the urine albumin/creatinine ratio (ACR) of DM subjects with nephropathy were 644.74 mg/ g and DM without nephropathy of 10.071 mg/g (p<0.001) and the correlation test results of urine PDX and urine ACR in DM subjects with nephropathy (r=0.510; p=0.001). This study concluded that there was a significant difference between urinary PDX in DM with and without diabetic nephropathy, there was a significant difference between urine ACR levels in DM with and without diabetic nephropathy, and there was a relationship between urinary PDX levels and urine ACR in DM subjects with diabetic nephropathy.
Co-Authors Liong Boy Kurniawan, Liong Boy Nurahmi, Nurahmi Orno, Theosobia Grace Theosobia Grace Orno Umar, Husaini Widaningsih, Yuyun Zainuddin, Alfian