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All Journal HAYATI Journal of Biosciences Molekul: Jurnal Ilmiah Kimia
Anggraini, Putri Regita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology

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In Silico and In Vivo Studies of Carboxymethyl Cellulose Based Hydrogels from Cassava Stem and Young Papaya Seed Extract for Diabetic Wounds Rahmawati, Risma; Lestari, Annisa Firda; Anggraini, Putri Regita; Safitri, Rahmadita Irma; A'yunin, Alfi Rizki; Firdaus, Maulidan
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.7286

Abstract

ABSTRACT. Diabetic chronic wound care remains a global challenge due to higher rates of infection leading to amputations and death. The development of wound dressing materials with good biocompatibility, adequate mechanical strength, high absorption, and anti-inflammatory and antibacterial properties are criteria for ideal wound dressings in clinical applications. This study aimed to prepare hydrogel plasters based on carboxymethyl cellulose (CMC) from cassava stems (Manihot esculenta C.) with the addition of an active substance from young papaya seeds (Carica papaya L.) for diabetic wound healing. The methods used included CMC synthesis, extraction of young papaya seeds, preparation of nanoparticles, hydrogel optimization using Response Surface Methodology (RSM), in silico study, and in vivo tests. All products for each stage were characterized by FTIR and XRD. Hydrogels were characterized by testing pH, organoleptic, swelling ratio, gel fraction, biodegradability, FTIR, and SEM. The results of RSM optimization obtained hydrogel with the formula Na-CMC 3%, citric acid 2%, and stirring temperature 70. Based on the in-silico test results, the apigenin compound has the lowest binding energy, namely -9.4 kcal/mol, so it has the potential to heal diabetic wounds by triggering angiogenesis through the VEGFR2 signal. In vivo test results showed that the hydrogel with the addition of young papaya seed extract had the fastest wound healing rate compared to other treatments, marked by 100% wound closure on the 10th day. Keywords: carboxymethyl cellulose, cassava stem, diabetes wound, hydrogel, young papaya seeds.
Arrowroot (Maranta arundinacea L.) Tuber Extract Modulated Gut Microbiota and Improved Glycemic Control in Type 2 Diabetic Mice Pangastuti, Artini; Anggraini, Putri Regita; Listyawati, Shanti; Sari, Siti Lusi Arum
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.371-381

Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia and has become a global health concern. Gut microbiota alterations significantly influence diabetes onset, which can be mitigated through prebiotic intake. Arrowroot tubers (Maranta arundinacea L.) possess prebiotic potential due to their oligosaccharide and dietary fiber content. This study evaluated the effects of arrowroot tuber extract on blood glucose, glucose tolerance, and gut microbiota composition in a T2DM mouse model. Tubers were macerated in ethanol, and BALB/c mice were fed a high-fat diet for five weeks, followed by streptozotocin injection (35 mg/kg) to induce T2DM. Mice received 150 mg of arrowroot tuber extract orally for 28 days. Blood glucose levels were measured on days 0, 14, and 28, and an oral glucose tolerance test (OGTT) was performed. Cecal samples collected after four weeks underwent 16S rRNA sequencing, and data were analyzed using One-Way ANOVA (p<0.05). Treatment with arrowroot tuber extract for 28 days reduced blood glucose levels by 40.5% and improved glucose tolerance. The extract modulated gut microbiota, decreasing harmful bacteria while increasing short-chain fatty acid (SCFA)-producing genera such as Lachnospiraceae NK4A136, Ligilactobacillus, and Alistipes. These results indicate that arrowroot tuber extract can beneficially alter gut microbiota composition and ameliorate hyperglycemia, suggesting its potential as a prebiotic-based therapeutic strategy for managing T2DM.
Co-Authors A'yunin, Alfi Rizki ARTINI PANGASTUTI Lestari, Annisa Firda Maulidan Firdaus Risma Rahmawati Safitri, Rahmadita Irma Sari, Siti Lusi Arum Shanti Listyawati