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All Journal Indonesian Biodiversity Journal Molekul: Jurnal Ilmiah Kimia Indonesian Biodiversity Journal
Migau, Natalina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Bioactivity of Papua Red Fruit Extract (Pandanus conoideus L.) Against Superoxide dismutase, Malondialdehyde and Blood Glucose of Rat (Rattus norvegicus L.) Hyperglycemia Mokosuli, Yermia Semuel; Migau, Natalina; Wurarah, Masje
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.9029

Abstract

Red fruit (Pandanus conodus L.) is a plant native to Papua, ethnomedical used as a traditional medicine with a wide spectrum of pharmacological effects. However, research on the bioactivity of red fruit is still very poorly reported. The aim of this study was to characterize the bioactive content, antioxidant bioactivity and the effect of lowering blood glucose in hyperglycemic rats. Red fruit has extracted used the maceration method with 95% ethanol. Analysis of active compound content using Gas Chromatography Mass Spectrophotometry (GC MS). Analysis of Malondialdehyde (MDA), Superoxide dismutase (SOD) and blood glucose levels was carried out using the in vivo method using white rats. The research results showed that red fruit ethanol extract contained 173 compounds from six main groups of compounds. Red fruit extract has effective in reducing MDA levels in hyperglycemic mice. K4 and K5 treatments were the best treatments for reducing MDA. Red fruit extract affects the duration of induction of increased SOD in hyperglycemic rats. Treatments K4 and K5 were the best treatments for SOD induction. Red fruit extract affects reducing blood glucose in hyperglycemic mice. Red fruit extract has antioxidant activity and lowers blood glucose. Red fruit extract has the potential to be developed as a source of bioactive antioxidants and antidiabetics. Keywords: Glucose, hyperglycemia, malondialdehyde, superoxide dismutase
The Antioxidant Activity of Red Fruit Extract (Pandanus conoideus L.) From Nabire Papua Migau, Natalina; Mokosuli, Yermia; Wurarah, Masje; Manampiring, Nonny
Indonesian Biodiversity Journal Vol. 5 No. 1 (2024): April 2024
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v5i1.9174

Abstract

Red fruit (Pandanus conoideus Lam) is a native Papuan plant which has been used by indigenous Papuan people as a medicinal plant. Papuan people believe that red fruit has a broad spectrum of pharmacological activity. This research aims to obtain antioxidant activity, namely reducing DPPH free radicals from Papuan red fruit ethanol extract. Samples of red fruit obtained from Nabire Papua. After determination, the red fruit is extracted using the maceration method. The ethanol extract of red fruit was then used for the DPPH antioxidant test method. The results showed that the ethanol extract of red fruit contains phenolic compounds: flavonoids, tannins; and steroids in high intensity. Ethanol extract of red fruit has very strong antioxidant activity (46.99 ppm; R2=0.99). Ethanol extract of Papuan red fruit has potential as a source of bioactive natural antioxidants.
The Antioxidant Activity of Red Fruit Extract (Pandanus conoideus L.) From Nabire Papua Migau, Natalina; Mokosuli, Yermia; Wurarah, Masje; Manampiring, Nonny
Indonesian Biodiversity Journal Vol. 5 No. 1 (2024): April 2024
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v5i1.9174

Abstract

Red fruit (Pandanus conoideus Lam) is a native Papuan plant which has been used by indigenous Papuan people as a medicinal plant. Papuan people believe that red fruit has a broad spectrum of pharmacological activity. This research aims to obtain antioxidant activity, namely reducing DPPH free radicals from Papuan red fruit ethanol extract. Samples of red fruit obtained from Nabire Papua. After determination, the red fruit is extracted using the maceration method. The ethanol extract of red fruit was then used for the DPPH antioxidant test method. The results showed that the ethanol extract of red fruit contains phenolic compounds: flavonoids, tannins; and steroids in high intensity. Ethanol extract of red fruit has very strong antioxidant activity (46.99 ppm; R2=0.99). Ethanol extract of Papuan red fruit has potential as a source of bioactive natural antioxidants.
Co-Authors Manampiring, Nonny Masje Wurarah Masye Wurarah Mokosuli Yermia Samuel