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All Journal Molekul: Jurnal Ilmiah Kimia
Nafiah, Mohamad Azlan
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Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology

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Triterpenoids From Swietenia mahagoni L Jacq. and Their Cytotoxic Activity against MCF-7 Breast Cancer and CV-1 Normal Kidney Cell Lines Supratman, Unang; Abdullah, Fajar Fauzi; Farabi, Kindi; Nurlelasari, Nurlelasari; Awang, Khalijah; Nafiah, Mohamad Azlan
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.9358

Abstract

ABSTRACT. Triterpenoid is a group of natural products with various remarkable activities, including cytotoxic. One of the sources for this type of compounds is Swietenia genus belong to Meliaceae family. This genus known to contains various secondary metabolites including limonoids, flavonoids, and triterpenoids. Especially for triterpenoid, there is limited report on isolation as well as biological activity from Swietenia genus, such as Swietenia mahagoni. In this research, three triterpenoid compounds have been successively isolated and identified from n-hexane extract, namely, (-)-leucophyllone (1), toonaciliatavarin E (2), and moronic acid (3). All isolated were assed against MCF-7 breast cancer and CV-1 normal kidney cell lines. The result showed that only moronic acid (3) performed moderate activity against two cells with IC50 of 63.10 and 48.04 µM, respectively. The other isolated compounds (1 and 2) showed weak cytotoxicity with IC50 > 500 µM. Based on preliminary structure activity relationship, revealed that pentacyclic triterpenoid (moronic acid, 3) showed stronger cytotoxicity compare with tetracyclic triterpenoids (-)-leucophyllone (1) and toonaciliatavarin E (2). Keyword: Cytotoxicity, MCF-7 and CV-1, Switennia mahagoni, Triterpenoids.
Four Azadirone-Type Limonoids from Chisocheton Pentandrus Stem Bark and Their Cytotoxic Acitivity Against Mcf-7 Breast Cancer Cell Lines Supratman, Unang; Runadi, Dudi; Naini, Al Arofatus; Purnama, Purnama; Mayanti, Tri; Harneti, Desi; Nurlelasari, Nurlelasari; Maharani, Rani; Farabi, Kindi; Nafiah, Mohamad Azlan
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.11085

Abstract

ABSTRACT. Limonoid group belongs to triterpenoid that has undergone further oxidation accompanied by the loss of four carbon atoms to form a furan ring in the chain. This limonoid compound is often found in the Chisocheton genus. Limonoid compounds have been known as compounds with high structural variations and this makes limonoids have diverse and interesting activities, including cytotoxic and anticancer. In the course of our continuing study for limonoid constituents that have cytotoxic activity against cancer cell lines, methanol extract of stem bark from the Chisocheton pentandrus plant provides significant activity. The methanol extract was separated using various chromatographic techniques in the normal and reverse stationary phase to produce four azadirone-type limonoid compounds (1-4). The elucidation structure of 1-4 was determined using spectroscopic methods including, UV-Visible, IR, and 1D-NMR as well as optical rotation. All four known compounds were established as trichilenone acetate (1), toonaciliaton C (2), 11α-acetoxiazadiron (3), and 16β-hydroxydisobinine (4). The cytotoxicity of compounds 1-4 was assessed by examination using the resazurin method, which showed that compound 4 was the promising constituent against the MCF-7 cells with an IC50 value of 43.1 µM and was stronger than its positive control. Keywords: Azadirone-type limonoid, Chisocheton pentandrus, cytotoxic activity, Meliaceae.
Co-Authors Desi Harneti Putri Huspa DUDI RUNADI Fajar Fauzi Abdullah Farabi, Kindi Khalijah Awang Naini, Al Arofatus Nurlelasari Nurlelasari Purnama Purnama Rani Maharani Tri Mayanti Unang Supratman