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All Journal Indonesian Journal of Community Empowerment Molekul: Jurnal Ilmiah Kimia
Fajar Fauzi Abdullah
Universitas Padjadjaran
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Social Sciences Other

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Triterpenoids From Swietenia mahagoni L Jacq. and Their Cytotoxic Activity against MCF-7 Breast Cancer and CV-1 Normal Kidney Cell Lines Supratman, Unang; Abdullah, Fajar Fauzi; Farabi, Kindi; Nurlelasari, Nurlelasari; Awang, Khalijah; Nafiah, Mohamad Azlan
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.9358

Abstract

ABSTRACT. Triterpenoid is a group of natural products with various remarkable activities, including cytotoxic. One of the sources for this type of compounds is Swietenia genus belong to Meliaceae family. This genus known to contains various secondary metabolites including limonoids, flavonoids, and triterpenoids. Especially for triterpenoid, there is limited report on isolation as well as biological activity from Swietenia genus, such as Swietenia mahagoni. In this research, three triterpenoid compounds have been successively isolated and identified from n-hexane extract, namely, (-)-leucophyllone (1), toonaciliatavarin E (2), and moronic acid (3). All isolated were assed against MCF-7 breast cancer and CV-1 normal kidney cell lines. The result showed that only moronic acid (3) performed moderate activity against two cells with IC50 of 63.10 and 48.04 µM, respectively. The other isolated compounds (1 and 2) showed weak cytotoxicity with IC50 > 500 µM. Based on preliminary structure activity relationship, revealed that pentacyclic triterpenoid (moronic acid, 3) showed stronger cytotoxicity compare with tetracyclic triterpenoids (-)-leucophyllone (1) and toonaciliatavarin E (2). Keyword: Cytotoxicity, MCF-7 and CV-1, Switennia mahagoni, Triterpenoids.
Application of Green Chemistry by Making Eco-enzyme-Based Dishwashing Liquid Soap at Roufus Sunnah Islamic Boarding School Alawiyah, Aika Latifah; Ruchiyat, Ruchiyat; Abdullah, Fajar Fauzi; Sari, Sinta Delia; Kamilah, Mila Wighoyatul
Indonesian Journal of Community Empowerment (IJCE) Vol 3 No 04 (2022): Indonesian Journal of Community Empowerment (November)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v3i04.921

Abstract

The application of green chemistry is an effort to reduce the negative impact on the environment, one of which is eco-friendly dishwashing liquid soap. It hasn’t been commonly used by the public, including Roufus Sunnah Sucinaraja Garut Islamic Boarding School students. This community service activity aims to increase students’ knowledge about eco-friendly alternative chemicals in dishwashing liquid soap products. This activity is also expected to empower students to produce dishwashing liquid soap independently and have the provisions for entrepreneurship. The method in this community service is counselling and practice in making eco-enzyme-based dishwashing liquid soap. Pre-tests and post-tests were conducted on students during the implementation of the activity. They were enthusiastic about participating in this activity. The students’ understanding increased regarding eco-friendly chemicals for dishwashing liquid soap and their skills in making these products
Co-Authors Alawiyah, Aika Latifah Farabi, Kindi Kamilah, Mila Wighoyatul Khalijah Awang Nafiah, Mohamad Azlan Nurlelasari Nurlelasari Ruchiyat, Ruchiyat Sari, Sinta Delia Unang Supratman