Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Buletin Kedokteran dan Kesehatan Prima International Journal of Public Health Excellence (IJPHE)
Lumbantobing, Christina J.R.E.
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
The Effect of Administration of Rosella Flower (Hibiscus Sabdariffa) Extract Gel on The Expression Of TNF-α And Caspase-3 Expression in An In Vivo Study of Wistar Strain Rats Exposed to Ultraviolet B-Lights Purboningtyas, Dyah Nisma; Lumbantobing, Christina J.R.E.; Lubis, Yolanda Eliza Putri
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.753

Abstract

UV rays are oxidative because they can produce Reactive Oxygen Species and free radical compounds. The dangers of sun exposure can cause skin disorders such as aging at an early age (photoaging). Rosella flower petals can be used in medicine, jams, and natural food coloring because they contain flavonoids as antioxidants or free radical scavengers. The research aimed to determine the effect of administering Rosella (Hibiscus sabdariffa L.) flower extract gel on TNF-α expression and Caspase-3 expression in an in vivo study of Wistar mice exposed to UVB. This research is an experimental study. The sample for each treatment group consisted of 6 individuals, so the total research sample was 24. Data analysis used descriptive, normality, and homogeneity tests with data analysis processing using SPSS 25.0 for Windows. The study found that administration of rosella flower extract gel with a concentration of 15% effectively reduced the expression of TNF-α and Caspase-3 in mice exposed to UVB light and produced filled and dense collagen. So, it can be concluded that rosella flower extract gel can act as an antioxidant that inhibits the growth of TNF-α and Caspase-3 expression.
The Effect of Administration of Rosella Flower (Hibiscus Sabdariffa) Extract Gel on The Expression Of TNF-α And Caspase-3 Expression in An In Vivo Study of Wistar Strain Rats Exposed to Ultraviolet B-Lights Purboningtyas, Dyah Nisma; Lumbantobing, Christina J.R.E.; Lubis, Yolanda Eliza Putri
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.753

Abstract

UV rays are oxidative because they can produce Reactive Oxygen Species and free radical compounds. The dangers of sun exposure can cause skin disorders such as aging at an early age (photoaging). Rosella flower petals can be used in medicine, jams, and natural food coloring because they contain flavonoids as antioxidants or free radical scavengers. The research aimed to determine the effect of administering Rosella (Hibiscus sabdariffa L.) flower extract gel on TNF-α expression and Caspase-3 expression in an in vivo study of Wistar mice exposed to UVB. This research is an experimental study. The sample for each treatment group consisted of 6 individuals, so the total research sample was 24. Data analysis used descriptive, normality, and homogeneity tests with data analysis processing using SPSS 25.0 for Windows. The study found that administration of rosella flower extract gel with a concentration of 15% effectively reduced the expression of TNF-α and Caspase-3 in mice exposed to UVB light and produced filled and dense collagen. So, it can be concluded that rosella flower extract gel can act as an antioxidant that inhibits the growth of TNF-α and Caspase-3 expression.
Breast cancer patients' quality of life during chemotherapy at Royal Prima General Hospital Saragih, Chanli; Lumbantobing, Christina J.R.E.; Chiuman, Linda; Sylvana, Dhini; Ibnu, Syahroni; Yuliansyah, Jeri; Iskandar, Ari Rahman
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.8049

Abstract

Background: Breast cancer is the most prevalent malignancy and a leading cause of cancer-related death among women worldwide. Chemotherapy, a primary treatment modality, often significantly impacts patient quality of life (QoL). This study aimed to analyze the QoL of breast cancer patients undergoing chemotherapy at Royal Prima General Hospital. Methods: We employed a descriptive-analytic cross-sectional design with a purposive sample of 51 patients. Data were collected using a respondent characteristics form and the validated Indonesian version of the WHOQOL-BREF instrument. Results: Results indicated the majority of respondents were aged 36-60 years (86.3%), married (100%), had a junior high school education (49%), and had a disease duration of 1-24 months (82.4%). Overall QoL for most patients was moderate (60.8%), followed by good (35.3%) and poor (3.9%). Cross-tabulation analysis revealed varied QoL distribution across age, marital status, education, disease duration, and cancer stage. Conclusion: We conclude that the QoL of breast cancer patients undergoing chemotherapy at Royal Prima General Hospital is predominantly at a moderate level, indicating a need for focused attention on psychosocial support, health education, and symptom management to holistically improve patient well-being during treatment.
Co-Authors Chiuman, Linda Ibnu, Syahroni Iskandar, Ari Rahman Purboningtyas, Dyah Nisma Saragih, Chanli Sylvana, Dhini Yolanda Eliza Putri Lubis Yuliansyah, Jeri