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UJI EFEKTIVITAS EKSTARK BUNGA PEPAYA TERHADAP KOLESTEROL MENCIT JANTAN YANG DI INDUKSI SUKROSA Tampubolon, Ester Juanita; Marpaung, Febri Sri Astuti; Andika, Muhammad Insan; Lubis, Yolanda Eliza Putri; Mutia, Maya Sari
(Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Vol 5, No 4 (2020): JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat)
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37887/jimkesmas.v5i4.15365

Abstract

Abstrak Penelitian ini bertujuan untuk mengetahuiuji efektivitas ekstrak bunga pepaya terhadap kolesterol mencit jantan yang di induksi dengan sukrosa. Kolesterol adalah salah satu lemak tubuh yang berada bentuk dalam asam lemak bebas dan ester serta merupakan komponen utama selaput sel otak dan saraf. Salah satu buah-buahan yang mengandung serat tinggi yang dapat menormalkan tekanan darah adalah buah papaya. Buah pepaya banyak mengandung zat-zat kimia yang bermanfaat bagi tubuh, terutama pada pembuluh darah. Buah papaya kaya Karoten), vitamin C, akan vitamin A ( pektin dan enzim papain). Enzim lipoprotein lipase ini merupakan enzim yang berperan dalam menurunkan kadar trigliserida, sehingga dengan adanya gangguan insulin, hidrolisis trigliserida cenderung meningkat dan menyebabkan meningkatkan kadar trigliserida. Berdasarkan hasil diatas menunjukkan bahwa kelompok perlakuan yang paling besar penurunan kolesterol adalah dengan ekstrak bunga pepaya dosis 400 mg/kgBB turun 4,80 %. Kata Kunci : Carrica papaya, Kolesterol, Sukrosa 
Ficus elastica Leaf Extract Effect Toward IL-10 and TNF-α as a Preeclampsia Model on Hypoxia-induced EA.hy926 Chrismis Novalinda Ginting; I Nyoman Ehrich Lister; Ermi Girsang; Maya Sari Mutia; Yolanda Eliza Putri Lubis; Annisa Amalia; Wahyu Setia Widodo; Dwi Surya Artie; Rizal Rizal; Wahyu Widowati
Journal of Mathematical and Fundamental Sciences Vol. 53 No. 3 (2021)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2021.53.3.10

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Preeclampsia is a pregnancy complication characterized by proteinuria, hypertension, hypoxia as well an increased systemic inflammatory response. It affects 5 to 10% of all births and is a leading factor in fetal and maternal morbidity and death. Ficus elastica L. leaves are known to have natural compounds with anti-inflammatory and antioxidant properties. This research assessed the potential of F. elastica leaf extract (FEE) as anti-inflammatory agent in a hypoxic-induced human endothelial cell line (EA.hy926) as preeclampsia model. F. elastica leaves were extracted using 70% ethanol. Cytotoxic assay of the FEE in different concentrations (3.13 to 100 µg/ml) against EA.hy926 was done using MTS assay. The FEE’s anti-inflammatory activity was measured with ELISA for the TNF-α and IL-10 parameters. The FEE did not cause cytotoxicity to the EA.hy926 cells, with viability above 80% at the highest concentration. The FEE could decrease the pro-inflammatory TNF-α level and increase the IL-10 level as anti-inflammatory markers in the preeclampsia model at significance level p < 0.05. This study suggests that FEE is a safe alternative herbal medicine for preeclampsia treatment.
Faktor-Faktor Risiko Yang Berhubungan Dengan Kejadian Kanker Prostat di Poliklinik Bedah Urologi RSUP H. Adam Malik Medan Yolanda Eliza Putri Lubis
PRIMER (Prima Medical Journal) Vol. 3 No. 2 (2018): Edisi Oktober
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang: Penyakit kanker merupakan salah satu penyebab kematian utama di seluruh dunia. Seiring dengan perjalanan usia, khususnya bagi pria usia lanjut harus meningkatkan kewaspadaan pada kondisi kesehatan tubuhnya. Kanker prostat umumnya terjadi pada pria di usia 50 tahun ke atas, tetapi sekarang ada juga yang berusia dibawah 50 tahun terkena kanker prostat, hal ini disebabkan oleh gaya hidup pria yang kebanyakan sudah merokok dan minum alkohol dari usia sangat muda. Faktor-faktor risiko kanker prostat cukup bervariasi, meliputi riwayat keluarga, obesitas, kebiasaan merokok, hubungan seksualm perilaku seks menyimpang dan konsumsi alkohol. Berdasarkan hal tersebut peneliti tertarik untuk meneliti faktor risiko kanker prostat di poliklinik bedah urologi RSUP H.Adam Malik, Medan Metode: Jenis penelitian yang dilakukan adalah survey analitik dengan menggunakan pendekatan retrospektif. Lokasi penelitian adalah di Poliklinik Bedah Urologi RSUP H.Adam Malik, Medan., dengan populasi kasus adalah penderita kanker prostat yang didiagnosis secara klinis, sebanyak 42 orang, populasi kontrol adalah yang tidak terdiagnosis Kanker Prostat atau kanker lainnya Hasil: Hasil analisis bivariat menunjukkan bahwa faktor-faktor yang berpengaruh terhadap kanker prostat meliputi riwayat keluarga (p=0,024, p<0,05) , kebiasaan merokok (p=0,041, p<0,05) dan riwayat penyakit sebelumnya (p=0,020, p<0,05). Faktor-faktor yang tidak berpengaruh terhadap kanker prostat meliputi obesitas (p=0,612,p>0,05), kebiasaan merokok (p=0,739, p>0,05), riwayat hubungan seksual (p=0,795, p>0,05) dan riwayat perilaku seks menyimpang (p=1,000, p>0,05). Kesimpulan: Dari hasil penelitian dapat disimpulkan bahwa terdapat hubungan antara riwayat keluarga, kebiasaan mengkonsumsi alkohol dan riwayat penyakit sebelumnya terhadap kejadian penyakit kanker prostat di poliklinik bedah urologi RSUP H.Adam Malik, Medan.
UJI EFEKTIVITAS EKSTRAK BUAH KESEMEK (DYOSPIROS KAKI L.) SEBAGAI ANTIBAKTERI TERHADAP BAKTERI ESCHERICHIA COLI Therry Prosperita K. Wau; Diaz F. Izdihar; Katherine Gunawan; Yolanda Eliza Putri Lubis
Jurnal Biologi Tropis Vol. 19 No. 2 (2019): Juli - Desember
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v19i2.1049

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Abstrak : Kesemek (Dyospyros kaki L.) merupakan buah yang berada di tanaman dataran tinggi (pegunungan). Dapat tumbuh dimana saja pada suhu rendah, kelembapan tinggi, intensitas matahari tidak 100% (teduh/mendung). Buah ini mempunyai kandungan senyawa yang memiliki potensi antimikroba yang menghambat pertumbuhan bakteri Escherichia coli. Penelitian ini bertujuan untuk mengetahui adanya efektifitas ekstrak kesemek terhadap pertumbuhan bakteri Escherichia coli pada konsentrasi 100%, 90%, 80%, 70%, 60%, dan 50%. Penelitian ini merupakan penelitian eksperimental laboratotium dengan metode difusi cakram.. Parameter yang diukur adalah besarnya zona hambat minimum dan zona hambat optimum ekstrak terhadap bakteri.  Hasil penelitian didapatkan ekstrak buah kesemek memiliki efektivitas antibakteri pada Escherichia coli, dimanazona hambat minimum rata-ratanya pada konsentrasi 70% (6,1 mm) dan zona hambat optimum rata-rata pada konsentrasi 100% (8,8 mm). Semakin tinggi konsentrasi ekstrak yang diberi maka semakin besar daya antibakterinya. Hasil ini menunjukan bahwa ekstrak buah kesemek memiliki efektivitas antibakteri yang lemah terhadap pertumbuhan bakteri Escherichia coli sesuai klasifikasi respon zona hambat bakteri.Kata kunci: Kesemek (Dyospyros kaki L.), antibakteri, Escherichia coli Abstract : Persimmon (Dyospyros kaki L.) is a fruit that is in highland (mountain) plants. Can grow anywhere at low temperatures, high humidity, the intensity of the sun is not 100% (shade / cloudy). This fruit contains compounds that have antimicrobial potential which inhibits the growth of Escherichia coli bacteria. This study aims to determine the effectiveness of persimmon extract on the growth of Escherichia coli bacteria at concentrations of 100%, 90%, 80%, 70%, 60%, and 50%. This study was an experimental laboratory with disc diffusion method. The parameters measured were the size of the minimum inhibition zone and the optimum zone of extract inhibition against bacteria. The results showed persimmon fruit extracts had antibacterial effectiveness in Escherichia coli, where the minimum inhibition zone was at a concentration of 70% (6.1 mm) and the optimum inhibition zone averaged at a concentration of 100% (8.8 mm). The higher the concentration of extract given, the greater the antibacterial power. These results indicate that persimmon fruit extract has a weak antibacterial effectiveness against the growth of Escherichia coli bacteria according to the classification of bacterial inhibitory zone responses.Keywords: Persimmon (Dyospyros kaki L.), antibacterial, Escherichia coli
Analyzed Psychological Impact Of An Effect Of Covid-19 On Mental Health On Health Personnel In Hospital Putri Hijau Medan Dessy Series Ulina Ginting; Santy Siregar; Yolanda Eliza Putri Lubis; Chrismis Novalinda Ginting
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 1 (2022): February 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.671 KB) | DOI: 10.51601/ijhp.v2i1.37

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The performance of nurses in hospitals is closely related to reliable, skilled, and professional human resources. Many factors that make it difficult for a person to care for a child are, in fact, length of work, training, motivation, incentives, work environment, and supervision.This research is for the treatment of the factors that is used in the preparation of nurse performance an analytical study with a cross-sectional approach (cross sectional). The research was conducted at Raden Mattaher Hospital, Jambi Province was 406 people and a sample of 261 people. Sampling by purposive sampling. Analyze the data with univariate, bivariate with chi-square test, and multivariate with multiple logistic regression at 95% confidence level ( = 0.05). The results showed that The factors in the development of Rumar General Hospital Raden Mattaher Jambi Province are education and training (p = 0.000), motivation (p = 0.000), incentives (p = 0.020), and supervision (p = 0.002). The variable that has no effect is age (p = 0.584), education (p = 0.786), length of work (p = 0.421), and work environment (p = 0.166). The most dominant variable affecting the performance of nurses is motivation with a value of Exp (B) / OR = 5.626, meaning that nurses who have high motivation have a 5.6 times higher chance of good performance than nurses with low motivation.
Analysis Of Knowledge, Characteristics, Attitude, And Behavior Of Nurses Regarding The Use Of Ppe (Personal Protection Equipment) In Accordance With Standard Operational Procedure (Sop) In The Inpatient Room Of Royal Prima Medan General Hospital Rama Atma Negara; Chrismis Novalinda Ginting; Yolanda Eliza Putri; Mangatas Silaen
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 4 (2022): November 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.491 KB) | DOI: 10.51601/ijhp.v2i4.101

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Personal Protective Equipment (PPE) is special clothing or equipment used for personal protection from infectious materials. Nosocomial infections are a global health problem. One of the most popular nosocomial infections is the case of the Corona-19 virus (COVID). PPE protects healthcare workers from infectious infections and helps prevent cross-contamination with other patients. The purpose of this study was to determine the analysis of knowledge, characteristics, attitudes, and behavior of nurses regarding the use of PPE according to the Standard Operational Procedure (SOP) in the Inpatient Room of the Royal Prima General Hospital, Medan. This type of research is an analytical observational study with a cross-sectional study design. There is a significant relationship between the characteristics, attitudes, and behavior of nurses on the use of PPE (p <0.05).
Analysis Of The Effect Of Job Demand Control-Support And Protection Motivation Towards Obedience With Filling In Medical Records At Batubara Hospital In 2021 Bayu Ramazata; Ermi Girsang; Yolanda Eliza Putri Lubis
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 3 (2022): August 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.195 KB) | DOI: 10.51601/ijhp.v2i3.108

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A medical record is part of the archive that describes all activities by an agency within a certain period. Hospitals must have medical records as a service standard in the health sector that is useful for improving quality in providing optimal service to patients. The problem that often arises in filling out medical records is that in the process of filling it is incomplete, and the doctor's writing is less specific about the diagnosis. This situation has an impact on internal and external hospitals because the results of data processing are the basis for making hospital internal reports and hospital external reports. This study aims to analyze the effect of job demand control-support and protection motivation on Obedience with filling in inpatient medical record files at Batubara Hospital in 2021. This type of research is analytical quantitative research. The sample size in this study was 105 people. Data analysis used Univariate, Bivariate, and Multivariate. The results showed Job Demand Control-Support inpatient nurses at Batubara Hospital in 2021 were good as many as 94 respondents and 11 respondents were not good, Protection Motivation at Batubara Hospital in 2021 was good as many as 95 and 10 were not good, Obedience in filling out files inpatient medical records at the Batubara Hospital in 2021, which complied with as many as 94 respondents and 11 respondents who did not obey, Job Demand Control-Support affects Obedience with filling out medical record files for hospitalization at Batubara Hospital in 2021, Protection Motivation affects Obedience in filling out files Medical records for hospitalization at Batubara Hospital in 2021. The variable that has the most influence on Obedience with filling in inpatient medical record files at Batubara Hospital in 2021 is the Protection Motivation variable
The Evaluation of Online Learning Modules to Increase the Capacity of Nurses and Midwives in Promoting Preconception Health in Primary Health Care Services at Tiara Kasih Sejati Hospital Pematangsiantar Agnes Rya Sianturi; Chrismis Novalinda Ginting; Yolanda Eliza Putri Lubis
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.227 KB) | DOI: 10.51601/ijhp.v3i1.147

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This study aims to find out how to develop an online learning module to increase the capacity of nurses and midwives in promoting preconception health in primary health care services at Tiara Kasih Sejati Hospital Pematangsiantar. This type of research is classified into descriptive research with a quantitative approach. The sample of this study amounted to 93 samples consisting of midwives and nurses. Data was collected by using counseling methods and giving questionnaires. Data analysis using univariate. The results showed the difference in the increase in respondents' knowledge of 4.34 so that the average score of respondents' knowledge before and before being given the online learning module increased from 9.52 to 13.86. The benefit of the module is to increase the perception of midwives and nurses in improving health preconceptions in primary health care settings by 75.3% of midwives and pediatric nurses increasing the promotion of health preconceptions in primary health care settings. The ability level of midwives and nurses in accessing online learning modules regarding preconception is 55.9% the best and 44.1% not good. The assessment of the quality of the online learning module given to midwives and nurses, midwives and nurses who rated it good was 77.4% and those who rated it bad were 22.6%. The nutritional needs needed during the preconception period are macronutrients and micronutrients.
Analysis Of Inpatient Medical Record Management Based On Medical Record Service Standards At Government Hospitals In Medan Muhammad Hasan Basri Nasution; Sri Wahyuni; Yolanda Eliza Putri Lubis; Ali Napiah Nasution
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 4 (2022): November 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.753 KB) | DOI: 10.51601/ijhp.v2i4.153

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Inpatient medical records have an important role as a source of data and health information for inpatients related to treatment and care planning. The main factor that causes problems in inpatient medical records is the undisciplined factor of the person in charge who handles patients in filling out medical records. This can cause inpatient medical record management, not in accordance with medical record service standards. This study aimed to analyze inpatient medical record management based on medical record service standards. This research is a quantitative analytic study with a cross-sectional approach. The study was conducted at the Government Hospital in Medan. The research population was 126 people and all of them were used as samples. Sampling by means of total sampling. Data analysis used univariate, bivariate with chi-square test, and multivariate with multiple logistic regression at 95% confidence level (0.05). The results showed that inpatient medical record management implementation based on medical record service standards at the Government Hospital in Medan was influenced by work motivation (p = 0.001) and supervision (p = 0.000). While the variables that have no effect are length of work (p = 1,000), education (p = 0.848), teamwork (p = 0.241), and completeness of infrastructure (p = 0.760). The supervision variable is the most dominant variable or has the greatest influence with the value of Exp(B)/OR = 19,542. Medical record employees who state that supervision is carried out well by superiors will improve the implementation of inpatient medical record management well, compared to those who state that supervision is still not good. It is recommended that the leadership carry out inherent supervision (waskat) to all medical record employees and provide motivation through motivational seminars to improve the implementation of inpatient medical record management based on medical record service standards.
The Effect Of Characteristic, Psychological And Organizational Factors On Nurse Performance At Royal Prima Hospital Abrianus Sarumaha; Ermi Girsang; Yolanda Eliza Putri Lubis; Sri Wahyuni Nasution
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 2 (2023): May 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i2.116

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Nurse performance is a determining factor in the success of achieving hospital goals in nursing services. Various studies on the performance of nurses in Indonesia show that the performance of nurses is still relatively low between 47.6% - 53.4%. Nurse performance is thought to be influenced by 3 factors, namely individual factors, psychological factors and organizational factors. The purpose of this study was to analyze the effect of characteristic, psychological, and organizational factors on nurse performance. This research is a quantitative research with a cross sectional study approach. The research was conducted at the Royal Prima Hospital, Medan. The research population was 367 people, the sample obtained was 115 people. Sampling by purposive sampling. Data analysis was univariate, bivariate with chi-square test, and multivariate with multiple logistic regression at 95% confidence level ( a=0.05). The results showed that the factors that influence the performance of nurses at the Royal Prima General Hospital Medan are psychological factors (job satisfaction) (p=0.011), organizational factors (leadership and organizational culture) respectively p = 0.004 and p = 0.002. Individual characteristic factors had no effect, namely age (p=1,000), gender (p=0.661), education (p=0.454), and years of service (p=0.090). The most dominant variable influencing the nurse's performance is the leadership variable, Exp(B)/OR = 6.633, meaning that the nurse who states leadership is in a good category has a 6.6 times higher chance of having a good performance than the nurse who states that leadership is not good. It is recommended that the leadership of the Royal Prima General Hospital Medan to provide guaranteed incentives to all nurses so as to increase satisfaction. Head of the room to demonstrate leadership that is acceptable to all parties. Hospitals should maintain and improve the organizational culture that has been good so far.
Co-Authors Abrianus Sarumaha Agnes Rya Sianturi Aleksander Marganda Sidebang Ananda, Rayhan Khozin Aulia Andika, Muhammad Insan Annisa Amalia Aulia, Nathasyia Bayu Ramazata Br Sitepu, Rachel Maria Cruz Jovanca Buaya, Adjani Chrismis Novalinda Ginting Chrismis Novalinda Ginting Chrismis Novalinda Ginting Chrismis Novalinda Ginting Chrismis Novalinda Ginting Christine Wira Dika Juliana Halawa Claudya Claudya Delfian, Taufik Depari, Sania Angelisa F Dessy Series Ulina Ginting Dewani Silaban, Grace Diaz F. Izdihar Doladave, Miguelle Franklin Dwi Surya Artie Ermi Girsang Ermi Girsang Ermi Girsang Ermi Girsang Evan charista ziraluo Faridahanum, Faridahanum Febri Sri Astuti Marpaung Ginting, Chrismis Novalinda Ginting, Frisdayanti Br Gurusinga, Fransisco Bastanta Hamsi, Ulpah Zahara I Nyoman Ehrich Lister Kaban, Karmila Katherine Gunawan Laia, Lisbetaria Lawrence, Christopher Lisya, Cut Lumban Gaol, Nova Elisabeth Lumbantobing, Christina J.R.E. Manao, Oktoriadi Mangatas Silaen Manurung, Charles Marpaung, Febri Sri Marpaung, Febri Sri Astuti Maulidi, Risyad Rizki Maya Sari Mutia Maya Sari Mutia Maya Sari Mutia Meilando, Rifki Monica, Veny Mughni Muchtar, Aisyah Muhammad Hasan Basri Nasution Muhammad Yunus Mutia, Maya Sari Nabila, Putri Nadeak, Gideon Nadi, Edlin Nardi, Leo Nasution, Ali Napiah Nasution, Masdalena Nazara, Niscaya Aprian Pangaribuan, Novita Helshinta Dewi Pearlie, Michelle Maydelaine Pratomo, Fransiskus Aryo Purboningtyas, Dyah Nisma Puspawani , Yeni Puspawani, Yeni Putranto Manalu Putri Handayani Putri, Shafyra Mahdyah Rahmi Arianti Rama Atma Negara Ramadhini, Amelya Putri Rambe, Daffa Jihan Azmi Reghita Claudia Malau Rena Meutia Rizal Rizal Rizky, Muhammad Irvan Roland Daniel Theodore Amudi Matondang Santy Siregar Sari, Ajeng Mestika Sheridan, Princessa Fath Silitonga, Impola Dinita Felicia Sitepu, Bintang Darma M Soekardi, Adi Sri Wahyuni Stevenie - Suandy , Suandy Suandy, Suandy Tafonao, Rachel Julia Tampubolon, Ester Juanita Tampubolon, Ester Juanita br. Therry Prosperita K. Wau Wahyu Setia Widodo Wahyu Widowati Widya Yanti Sihotang Zuhra, Layla