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All Journal Pharmacy Reports Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies Jurnal Farmasi Indonesia
Rukmana, Taufiq Indra
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Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Social Sciences

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Analisis Pengelolaan Obat di Puskesmas Margamulya Kecamatan Bekasi Utara Tahun 2021 Rukmana, Taufiq Indra; Nusaiba, Putri; Sitepu, Eme Stepani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.134

Abstract

Primary Health Center still has problem in drug management, especially in drug availability, storage, and drug inventory control. This study aims to analyze whether drug management at the Margamulya Primary Health Center in 2021 met the standard indicators of drug management. This study used observational descriptive research methods. Data collection was carried out using secondary data tracing (retrospective), direct observation (concurrent), and interviews. The collected data were then analyzed with drug management indicators consisting of 26 indicators. The analysis results showed that drug management at the Margamulya Primary Health Center met 9 indicators, but did not meet 15 indicators, when compared to standards. In addition, 2 indicators could not be analyzed because of lack of data. Thus, it is necessary to review aspects of drug inventory control, to increase the number, soft skills and knowledge of pharmacist in pharmaceutical services, and to implement management information system in the Primary Health Center.
Eko Aditya Rifai (1989-2021): An outstanding Indonesian young scientist on bioinformatics Rukmana, Taufiq Indra
Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.061 KB) | DOI: 10.51511/pr.13

Abstract

An outstanding Indonesian young scientist on bioinformatics
Synthesis of Ferrous Fumarate from Indonesian Iron Sand and In Vivo Body Weight Gain Test in Rats Rukmana, Taufiq Indra; Kurniadi, Felicia Natalia; Harmita, Harmita
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Iron deficiency anemia (IDA) is a health problem in Indonesia. Prevention and treatment of IDA is carried out by giving fortified foods and oral iron therapy. Both can use ferrous fumarate which is made with reacting bivalent iron and disodium fumarate. Bivalent iron can be obtained from iron sand in Indonesia. This study aims to synthesize ferrous fumarate from Indonesian iron sand, which is from Malang, Sukabumi, and Cianjur area, and to determine its absorption through in vivo body weight gain test in male Wistar white rats (Rattus norvegicus). First, ferrous fumarate was synthesized through reaction of ferrous sulfate, which was made from Indonesian iron sand with the highest iron content, which was from Sukabumi area, and disodium fumarate. Second, in vivo body weight gain test was conducted to 3 rat groups (negative control, ferrous sulfate group, and ferrous fumarate group, respectively) and monitored for two weeks. The results showed that ferrous fumarate was successfully obtained as brownish red-orange fine powder with yield of 62.17 ± 1.66 %. In addition, the in vivo body weight test suggested that the rats from ferrous fumarate group showed similar weight gain (35.1%) compared to those from the ferrous sulfate group (30.6%), indicating a possibility of iron absorption from ferrous fumarate.
Utilization of Near-Infrared Spectroscopy Combined with PLS-2 Regression Learner to Predict Metformin HCL Tablet Dissolution Profile Zakaria, Mohamad Rahmatullah; Sutriyo, Sutriyo; Hayun, Hayun; Rukmana, Taufiq Indra
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.1566

Abstract

One of the assurances of pharmaceutical tablet's quality, effectivity, and safety is the dissolution test, which is commonly known by pharmaceutical manufacturers. Conventionally, this test is performed by simulating the release rate of a drug using a Dissolution Tester, which mimics the human gastrointestinal condition. As stated by the current compendial for tablet dosage form, the dissolution rate is mandatory, with no exception for Metformin HCl tablets. This laboratory method is often time-consuming, unsafe for organic reagent exposure, and produces waste. This problem requires rapid, simple, and nondestructive technologies, hence having powerful analytical performance. One of the technologies that is widely used is Near Infrared (NIR) spectroscopy. This study utilized the NIR spectrum as a predictor to generate a mathematical model using Partial Least Square Regression (PLS-2) to build a dissolution rate model for the Metformin HCl tablet, which uses the Farmakope Indonesia IV <1231> (FI-IV) dissolution method as the compendial reference method. The PLS-2 model was built, which shows the low difference between SEC and SECV in each sampling point and a good correlation in the coefficient of determination (R2) of each point's time of dissolution within 0.900 to 0.953. The challenge test was performed to prove the predictability of the PLS-2 model with NIR against the actual reference FI-IV method using differential and similarity Factors (f2 & f1), enabling real-time release testing (RTRT).
Co-Authors Harmita Harmita, Harmita Hayun Hayun, Hayun Kurniadi, Felicia Natalia Nusaiba, Putri Sitepu, Eme Stepani Sutriyo Sutriyo, Sutriyo Zakaria, Mohamad Rahmatullah