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All Journal Jurnal Multidisiplin Madani (MUDIMA) Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia
Sitepu, Eme Stepani
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Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Industrial & Manufacturing Engineering Medicine & Pharmacology Social Sciences

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Evaluation of Potential Drug Interaction of Analgesic in Cancer Patient Receiving Palliative Care in Dharmais Cancer Hospital Sitepu, Eme Stepani; Puspitasari, Atika Wahyu; Azmi, Nuriza Ulul; Sari, Lila Nilam
Pharmaceutical Sciences and Research Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Analgesics are mostly used in cancer patients receiving palliative care to improve the quality of life of patients. Besides analgesics, cancer patients receiving palliative care were also given other drugs in combination to overcome other symptoms of cancer, and this combination could potentially cause drug interactions. This study was aimed to analyze the potential of drug interactions with analgesics in cancer patients. The study design was cross-sectional with a retrospective method and descriptive study. The sample of this study was cancer palliative care patient’s prescription at Dharmais Cancer Hospital in the period of January – December 2017. The sample analyzed in this study consisted of 273 prescriptions. This study found that there were 191 prescriptions (69.9%) of analgesics which potential- ly interacted with 316 interaction cases. Fentanyl and morphine with 61 cases (19.3%), morphine and gabapentin with 60 cases (18.9%) and morphine and amitriptyline with 33 cases (10.4%) were observed as the three most analgesics-other drugs interaction. Based on severity levels, there were 73.5% of major interaction, 26.3% of moderate interaction, and 0.2% of minor interaction. This study concluded that high occurrence of drug interactions was observed in analgesic drugs, therefore close monitoring is needed in cancer patient receiving palliative care.
Validasi Metode Analisis Ofloksasin dalam Plasma In Vitro secara Kromatografi Cair Kinerja Tinggi-Fluoresensi Mengacu pada European Medicines Agency Guideline Tania, Letitia; Sitepu, Eme Stepani; Harahap, Yahdiana
Pharmaceutical Sciences and Research Vol. 3, No. 2
Publisher : UI Scholars Hub

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Abstract

Ofloxacin is an antibiotic from second generation of fluoroquinolones group. Concentration of ofloxacin in human plasma is in low level, and due to that fact, it requires a selective, accurate, sensitive method of analysis. In this study, the optimization and validation of ofloxacin analysis in human plasma using high performance liquid chromatography-fluorescence with ciprofloxacin-HCl as an internal standard were carried out. Separation of ofloxacin was performed using C18 (Waters, SunfireTM 5 µm; 250 x 4.6 mm) column with an isocratic mobile phase consisted of triethylamine 1% in water pH 3.0–acetonitrile (84:16) in the flow rate of 1.0 mL/min, 40oC column temperature whereas the detection was carried out at excitation of 300 nm and emission of 500 nm. Plasma extraction was done by deproteination using methanol, through the process of vortex and centrifugation (10000 rpm) for 2 minutes and 10 minutes consecutively. The method was valid and linear within the concentration ranged from 21,4 ng/mL to 4280 ng/mL with LLOQ of 21,4 ng/mL. Intra-day and inter-day accuracy and presicion was not more than + 20% for LLOQ and not more than + 15% for QCL, QCM, and QCH samples in both % diff and coefficient of variation. Ofloxacin was stable in human plasma at least three freeze and thaw cycle, for at least 24 hours in room temperature and 28 days at -20oC. This bioanalytical method fulfilled the acceptance criteria following EMEA guideline.
Analisis Pengelolaan Obat di Puskesmas Margamulya Kecamatan Bekasi Utara Tahun 2021 Rukmana, Taufiq Indra; Nusaiba, Putri; Sitepu, Eme Stepani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.134

Abstract

Primary Health Center still has problem in drug management, especially in drug availability, storage, and drug inventory control. This study aims to analyze whether drug management at the Margamulya Primary Health Center in 2021 met the standard indicators of drug management. This study used observational descriptive research methods. Data collection was carried out using secondary data tracing (retrospective), direct observation (concurrent), and interviews. The collected data were then analyzed with drug management indicators consisting of 26 indicators. The analysis results showed that drug management at the Margamulya Primary Health Center met 9 indicators, but did not meet 15 indicators, when compared to standards. In addition, 2 indicators could not be analyzed because of lack of data. Thus, it is necessary to review aspects of drug inventory control, to increase the number, soft skills and knowledge of pharmacist in pharmaceutical services, and to implement management information system in the Primary Health Center.
Analisis Ketersediaan Obat pada Sebelum dan Selama Pandemi COVID-19 di RSUD Bali Mandara Provinsi Bali Sitepu, Eme Stepani; Ayuningtyas, Dumilah; Junadi, Purnawan; Satibi, Satibi; Daniel, Rizki
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.356

Abstract

The availability of drugs needs to be guaranteed to meet the needs of patients both in terms of quantity and type. This can be realized if drug management in the hospital is carried out effectively and efficiently. Factors that influence this include the suitability of planning methods, drug procurement, availability of e-catalog, good human resource competence, and budget adequacy. The challenges in the COVID-19 pandemic situation in 2020 are activity restrictions that affect the distribution of drugs and raw materials while the demand for drugs increases. This study aims to analyze the level of drug availability before the pandemic and during the COVID-19 pandemic at the Bali Mandara Provincial General Hospital. This study was conducted from September to December 2023 using a quantitative approach. Data were collected retrospectively using stocks, and drug procurement from 2019 to 2022. The results showed no incidents of poor drug stocks in 2019-2022. However, there was an increase in the percentage of safe category for the needs of 12-18 months from 2019 to 2022 by 42.5%, 44.4%, 69.1%, and 65.7%, respectively. There are still excessive stocks above 18 months although the percentage is decreasing at 37.9%, 26.2%, 21.6%, and 28.8%, respectively. The decrease in drug items with availability levels of more than 60 months was 15.7%, 8.6%, 7.0%, and 4.1%, respectively. There were expired drugs before and during the COVID-19 pandemic but the value of expired items decreased from Rp. 370,221,269.27 in 2019 to Rp.93,787,747.28 in 2022. Conclusion: The Hospital Pharmacy Department can fulfill the need for drugs before and during the COVID-19 pandemic, indicated by no incidents of drug shortages. However, it is necessary to manage drugs more efficiently, because there are still drugs without use in a year and expired drugs, although the percentage has decreased during the COVID-19 pandemic.
The The Effect of Using Different Anticoagulant Types for Determination of Esomeprazole Levels in Human Plasma by High-Performance Liquid Chromatography Mardhiani, Rizka; Harahap, Yahdiana; Sitepu, Eme Stepani; Sunarsih
Jurnal Multidisiplin Madani Vol. 3 No. 10 (2023): October, 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v3i10.4170

Abstract

Esomeprazole is a Proton Pump Inhibitor (PPI) drug formulated in delayed-release tablets, that are included in the mandatory bioequivalence test. In vitro method validation used human plasma from the Indonesian Red Cross that used citrate as an anticoagulant. In the implementation of in vivo study, usually using human plasma used EDTA or heparin as an anticoagulant. This study aims to evaluate the effect of using anticoagulant types that may affect the analysis of esomeprazole in human plasma. Optimum chromatographic conditions used column C18 SunfireTM (5 μm, 250 mm x 4.6 mm); column temperature 40°C; mobile phase acetonitrile - phosphate buffer (40:60% v/v) pH 7.6; 1.0 mL/min flow rate with lansoprazole as an internal standard and wavelength 300 nm (PDA). The extraction was carried out by liquid-liquid extraction method using 500 μl plasma and 5 ml dichloromethane as extraction solvent. The result showed that the concentration range of calibration curve linearity in 5 – 1500 ng/mL. Recovery and broad peak response data of esomeprazole in plasma have significant differences between heparin-EDTA and citrate-EDTA anticoagulants (p<0.05), but there is no significant difference for the stability test. In conclusion, heparin is better than EDTA as an anticoagulant for esomeprazole bioanalysis
Co-Authors Azmi, Nuriza Ulul Daniel, Rizki Dumilah Ayuningtyas Letitia Tania, Letitia Mardhiani, Rizka Nusaiba, Putri Purnawan Junadi Puspitasari, Atika Wahyu Rukmana, Taufiq Indra Sari, Lila Nilam Satibi Satibi Sunarsih Yahdiana Harahap