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All Journal Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation
Lely Hartati
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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PAPILLARY ADENOCARCINOMA OF THE LUNG Siti Aisyah; Lely Hartati; Amiruddin
MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Vol. 4 No. 4 (2023): December
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59733/medalion.v4i4.84

Abstract

Background : Lung cancer is the most common cause of cancer deaths worldwide. Mortality and incidence rates are generally highest in high-income countries, especially the United States and European countries. In the United States, it is estimated that 234,030 people were diagnosed with lung cancer in 2018. Adenocarcinoma is the most dominant type of histological lung cancer, with the papillary adenocarcinoma subtype rarely encountered.Case Report : A case was reported from a 66-year-old male with slaid number B / 4903/19. On macroscopic examination from biopsy tissue appeared gray, springy, with a volume of ± 0.2 cc. On microscopic examination, a tumor mass shows form a papillary structure with fibrovascular core and a small portion of solid. Consists of tumour cells with pleomorphic nuclei, rough chromatin, some with intranuclear vacuole, pale cytoplasm and protruding nuclei. Mitotic was found. Stroma consists of fibrous connective tissue infiltrated by tumor cells and inflammation of lymphocyte cells. Dilated blood vessels and congestion. Areas of necrosis and lymphovascular invasion were seen.Discussion and Conclusions : Based on the histopathological picture, the patient is diagnosed with papillary adenocarcinoma of the lung with a classical histology picture that makes it easy to established the diagnosis. Prognose was poor.
PULMONARY METASTASES FROM FIBROSARCOMA: A CASE REPORT Amiruddin; Pasca Sari Nauli Tamba; Lely Hartati
MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Vol. 5 No. 4 (2024): December
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59733/medalion.v5i4.171

Abstract

Introduction: Pulmonary metastases arising from extremity fibrosarcoma are among the most common sites of distant metastasis. The median survival after the occurrence of metastasis is approximately one year. Patients treated with nonoperative therapy have a median survival of 11 months. Case Illustrations: A 70-year-old female, never smoker, admitted to the hospital with a chief complaint of shortness of breath. The patient had a history of fibrosarcoma on the left foot followed by surgery a year ago. Chest X-ray showed central lung mass with massive right pleural effusion. Post-contrast chest imaging revealed a heterogeneous, enhancing, lobulated mass in both lungs. TTNA and core biopsy were performed under USG guidance on the lung mass. The cytologic findings revealed a metastatic neoplasm-suggestive sarcoma. The concomitant core biopsy showed a histologic pattern of spindle cells arranged in short intersecting fascicles suggestive of metastases of fibrosarcoma. The patient showed rapid deterioration resulting in death on the 20th day of hospitalization. Discussion: The incidence of fibrosarcoma in the lower limb accounts for 40% of all cases of soft tissue tumors. Patient with extremity sarcomas are more likely to have distant metastases as their initial site of recurrence. From the histologic pattern, those patients with spindle cell sarcoma were the most likely to have pulmonary metastases. Data on pulmonary metastases arising from extremity fibrosarcoma is poorly available making it difficult to treat metastatic sarcoma. Conclusion: Pulmonary metastases from fibrosarcoma are a challenging issue, with a median survival of less than one year post-metastasis. Pulmonary metastasectomy can extend survival to 33 months, but a multidisciplinary approach, including tailored chemotherapy and radiotherapy, is crucial due to the diverse tumor behaviors. This case highlights the rapid progression and poor prognosis of metastatic fibrosarcoma, underscoring the need for comprehensive treatment strategies.
High Grade Myxoid Round Cell Liposarcoma Fahmi Irsan Nasution; Lely Hartati; Muhammad Natsir Ilvira
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6230

Abstract

Background: Myxoid liposarcoma is a malignant tumor composed of uniform, partially round to oval cells with lipoblast, in the myxoid stroma with branching capillaries. Very rarely presents as a primary neoplasm of the subcutis or retroperitoneum. Myxoid liposarcoma in the retroperitoneum is the most common metastases. Case description: We reported a case of Mr M, male, 48 years old, came to the hospital. Private in the city of Medan on April 19 2021 with complaints of upper left abdominal pain, nausea (+), vomiting (-), fever. vital sign, general condition: compos mentis, temperature: 36 ℃, Pulse: 80 x/min. Breathing: 20x/min, Blood pressure: 120/80 mmHg. Previously, a gastric biopsy was performed on suspicion of gastric carcinoma and a histopathological examination was carried out with the results of a gastric adenoma. Subsequently, an exploratory laparotomy was performed with tumor debulking and the tissue was sent to the H. Adam Malik Hospital unit. On macroscopic examination, the tissue was split in a state of 16 cm x 12 cm x 7 cm, yellowish-gray in color, chewy consistency. The of cutting, a solid mass of white, yellow, and brown color appears, the consistency is chewy and brittle. With a tissue-weight of 800 grams then labeled O/1260/21. On microscopic examination of the tumor mass, it appears that the tumor mass is mostly arranged in solid sheets, consisting of round, relatively uniform cells, arranged back to back. Round and oval nuclei with increased N/C ratio, coarse chromatin, eosinophilic cytoplasm. Among them are lipoblast cells with spider web and small signet ring lipoblast. Atypical mitoses are relatively easy to find > 19 mitoses / 10 LPB. Proliferative and congested blood vessels, necrotic masses <50% are also seen. Immunohistochemical examination was carried out with S100 positive staining results on the nuclear membrane and cytoplasm of tumor cells with a proportion of more than 70% moderate to strong intensity. Conclusion: Based on macroscopic and microscopic examination this patient was diagnosed with High grade myxoid round cell liposarcoma grade III with ICD-O 8852/3.
Co-Authors Amiruddin Fahmi Irsan Nasution Muhammad Natsir Ilvira Pasca Sari Nauli Tamba Siti Aisyah