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All Journal Medicinus : Jurnal Kedokteran Magna Neurologica
Samudra, Edeline
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Factors Associated with Low Back Pain in Pre-Clinical Students in the Faculty of Medicine at Pelita Harapan University: Original Research Samudra, Edeline; Kalumpiu, Jane Florida
Medicinus Vol 13, No 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8881

Abstract

Background: Low back pain is one of the most common health problems globally, including in Indonesia, and can result in limitations on a person's activities. While low back pain is typically associated with adults and the elderly, its prevalence is also notably high among students, particularly medical students. Despite the various factors contributing to low back pain, there is limited data on its prevalence and associated factors in Indonesia.Methods: A cross-sectional study was conducted at the Faculty of Medicine, Pelita Harapan University, utilizing consecutive sampling. Data were collected using the Nordic Musculoskeletal Questionnaire, Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire (IPAQ), and Perceived Stress Scale (PSS).Results: Out of 179 students, 144 (80%) experienced low back pain, while 35 (20%) did not. Among students with low back pain, 1.4% had psychological history, 7.3% had history of spinal problems, 0.7% had family history, 15.3% were obese, 75% had poor sleep quality, 8.3% had high-risk physical activity, 6.9% had a high-risk position, and 7.6% had a high-risk stress level. While other factors showed no significant association with low back pain, sleep quality demonstrated a significant association with a p-value of 0.022 (OR 2.52, CI 1.18-5.43).Conclusion: There is a significant association between sleep quality and low back pain in pre-clinical medical students at UPH, while other factors did not exhibit significant correlations.
Factors Associated with Low Back Pain in Pre-Clinical Students in the Faculty of Medicine at Pelita Harapan University: Original Research Samudra, Edeline; Kalumpiu, Jane Florida
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8881

Abstract

Background: Low back pain is one of the most common health problems globally, including in Indonesia, and can result in limitations on a person's activities. While low back pain is typically associated with adults and the elderly, its prevalence is also notably high among students, particularly medical students. Despite the various factors contributing to low back pain, there is limited data on its prevalence and associated factors in Indonesia.Methods: A cross-sectional study was conducted at the Faculty of Medicine, Pelita Harapan University, utilizing consecutive sampling. Data were collected using the Nordic Musculoskeletal Questionnaire, Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire (IPAQ), and Perceived Stress Scale (PSS).Results: Out of 179 students, 144 (80%) experienced low back pain, while 35 (20%) did not. Among students with low back pain, 1.4% had psychological history, 7.3% had history of spinal problems, 0.7% had family history, 15.3% were obese, 75% had poor sleep quality, 8.3% had high-risk physical activity, 6.9% had a high-risk position, and 7.6% had a high-risk stress level. While other factors showed no significant association with low back pain, sleep quality demonstrated a significant association with a p-value of 0.022 (OR 2.52, CI 1.18-5.43).Conclusion: There is a significant association between sleep quality and low back pain in pre-clinical medical students at UPH, while other factors did not exhibit significant correlations.
Pediatric Epilepsy Surgery in A Drug-Resistant Epilepsy Patient Aggravated by SARS-CoV-2: A Case Report Samudra, Edeline; Ketaren, Retno Jayantri; Inggas, Made Agus Mahendra
Magna Neurologica Vol. 3 No. 2 (2025): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v3i2.1882

Abstract

Introduction: Epilepsy is a manageable neurological disorder, but about one-third of cases are classified as drug-resistant epilepsy (DRE). DRE in pediatrics is more complex and may lead to cognitive function impairment, while surgery can offer seizure control in cases of focal DRE. Case: A 10-year-old male presented with a four-year history of recurrent seizures, thought to be caused by a left temporal cerebral cyst diagnosed five years earlier. During episodes, he experienced body stiffness, bilateral eye twitching, and drooling, with intact consciousness. After SARS-CoV-2 exposure, seizures became more frequent despite antiepileptic treatment, leading to partial resection of the left temporal lobe nine months later. Two years post epileptic surgery, he has become drug-responsive and achieved seizure control with symptomatic relief through medication. Discussion: Epilepsy is common in children, and DRE should be considered in cases of intractable epilepsy. Various factors can cause DRE, and in this patient, SARS-CoV-2 is thought to aggravate seizures by binding to ACE2 receptors in the central nervous system. This neural interaction may trigger reactive astrogliosis and neuroinflammation, disrupting the balance between glutamate and GABA levels. However, epilepsy surgery has been effective in improving the quality of life. Conclusion: Epilepsy surgery, either resective or non-resective surgery, is still rarely performed in Indonesia, while the management of DRE may require surgery. Although complete seizure freedom is not guaranteed, surgery can often convert DRE into a drug-responsive condition.
Efficacy and Safety of Evobrutinib in Relapsing Multiple Sclerosis: A Systematic Review of Randomized Controlled Trials Samudra, Edeline; Anyeliria Sutanto
Magna Neurologica Vol. 3 No. 2 (2025): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v3i2.1929

Abstract

Background: Evobrutinib is a selective Bruton’s tyrosine kinase (BTK) inhibitor that crosses the blood-brain barrier. BTK regulates B lymphocytes and myeloid cells, significantly contributing to multiple sclerosis (MS) inflammation. While current MS treatments alleviate relapses and disability, they have a limited impact on inflammation within the central nervous system. Objective: We aim to evaluate the efficacy and safety of evobrutinib in relapsing MS. Methods: A systematic search of databases, including PubMed, Elsevier, NEJM, BMJ Journals, and Neurology, was conducted. Inclusion criteria: Studies within 5 years, randomized controlled trials, and interventions with evobrutinib. Exclusion criteria: Incomplete reporting, non-phase two trials, and JADAD score < 3. The quality of the included studies was evaluated using the JADAD scale. Results: The literature search yielded 552 studies, of which eight were included in the final analysis. All studies consistently demonstrated significant benefits in reducing disease activity. The efficacy of evobrutinib 75 mg BID showed a significant reduction in ARR (mean ARR = 0.10) and gadolinium-enhancing lesions compared to placebo (mean ARR = 0.37). SEL volume was significantly reduced, especially in patients with higher disability and longer disease duration. The safety profile of evobrutinib was comparable to that of a placebo, with similar rates of TEAEs. Liver enzyme elevations were noted in one study but were generally manageable. Stability in EDSS scores over extended treatment periods suggests effective disease control. Conclusion: Evobrutinib is a promising therapeutic option for managing MS, particularly relapsing forms, due to its efficacy in reducing disease activity and favorable safety profile.
Co-Authors Anyeliria Sutanto Jane Florida Kalumpiu, Jane Florida Ketaren, Retno Jayantri Made Agus Mahendra Inggas, Made Agus Mahendra