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Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections Buana, Ria; Kalumpiu, Jane Florida; Djuardi, Yenny; Supali, Taniawati
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.206-212

BackgroundSoil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta. MethodsA pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data. ResultsThe STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment. ConclusionsAlbendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world.

Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol Jane Florida Kalumpiu; Yenny Djuardi; Taniawati Supali
Universa Medicina Vol. 34 No. 2 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.121-128

BackgroundSoil-transmitted helminth (STH) infection is still a health problem in Indonesia. Vitamin A deficiency (VAD) is often found together with STH. The effect of the deworming program on the vitamin A status of primary school children is unknown. The objective of this study was to evaluate the effect of albendazole on serum retinol concentrations in primary school children.MethodsAn experimental study of pre-post test design without control was carried out on 118 children from grades 3-5 at one primary school in North Jakarta, from July to September 2014. Flotac examination was used to determine STH infections and high performance liquid chromatography was performed to measure serum retinol concentration. Stool and blood samples were taken twice: before and three weeks after treatment with albendazole 400 mg single dose for three consecutive days given to all children either infected or uninfected. Paired t-test was used to analyze the data. ResultsOf the 118 children, the prevalence of STH was 71.2%. The prevalence of low retinol serum (<1.05 mmol/L) was 17 (17.2%) and of mild VAD was 2 (2.0%). Albendazole given in 3 consecutive days could not increase serum retinol concentrations (p=0.055). Serum retinol concentration significantly increased after albendazole treatment in children with low retinol serum at baseline (p=0.001). ConclusionsIn children with low serum retinol concentration, treatment with albendazole increased retinol concentration. Integrated deworming and vitamin A supplementation strategies should be evaluated in this population.

Factors Associated With Atopic Dermatitis In Elementary School Children In Suburban Area In Indonesia: Original Research Gunawan, Catherine; Satriajaya, Anthony; Vatvani, Akhil Deepak; Waren, Kalis; Angela, Angela; Broto, Resza; Kalumpiu, Jane Florida; Tan, Sylvia
Medicinus Vol 12, No 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7034

Background: There was limited data of Atopic Dermatitis (AD) prevalence and its associated factors in Indonesia. Therefore, the aim of this study was to identify and evaluate the AD prevalence and factors associated with AD in elementary school children in suburban area in Banten.Methods: A cross-sectional study was conducted in 3 elementary schools children age 6 – 7 years old who were randomly selected. Information was obtained through an Indonesian version of the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC).Results: From 304 school children in semi-urban area, AD was reported as ever had an itchy rash which was reccurent for at least 6 months in 17.4% of the children, 19.5% of the children had this itchy rash at any time in the past 12 months, and 11.4 % reported doctor-diagnosed AD. The factors found to be associated with an increased risk of AD were allergic rhinitis (OR 2.151 CI: 1.086-4.261), history of premature birth (<37 weeks) (OR 5.306, CI:1.577-17.858), exclusive breastfeeding (OR 3.126 CI:1.314-7.439), and food allergy (OR 2.912 CI:1.386-6.119).Conclusion: The results of this study showed that allergic rhinitis, history of premature birth (<37 weeks), exclusive breastfeeding, and food allergy were factors associated with AD in Indonesian schoolchildren.

Factors Associated with Low Back Pain in Pre-Clinical Students in the Faculty of Medicine at Pelita Harapan University: Original Research Samudra, Edeline; Kalumpiu, Jane Florida
Medicinus Vol 13, No 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8881

Background: Low back pain is one of the most common health problems globally, including in Indonesia, and can result in limitations on a person's activities. While low back pain is typically associated with adults and the elderly, its prevalence is also notably high among students, particularly medical students. Despite the various factors contributing to low back pain, there is limited data on its prevalence and associated factors in Indonesia.Methods: A cross-sectional study was conducted at the Faculty of Medicine, Pelita Harapan University, utilizing consecutive sampling. Data were collected using the Nordic Musculoskeletal Questionnaire, Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire (IPAQ), and Perceived Stress Scale (PSS).Results: Out of 179 students, 144 (80%) experienced low back pain, while 35 (20%) did not. Among students with low back pain, 1.4% had psychological history, 7.3% had history of spinal problems, 0.7% had family history, 15.3% were obese, 75% had poor sleep quality, 8.3% had high-risk physical activity, 6.9% had a high-risk position, and 7.6% had a high-risk stress level. While other factors showed no significant association with low back pain, sleep quality demonstrated a significant association with a p-value of 0.022 (OR 2.52, CI 1.18-5.43).Conclusion: There is a significant association between sleep quality and low back pain in pre-clinical medical students at UPH, while other factors did not exhibit significant correlations.

Factors Associated With Atopic Dermatitis In Elementary School Children In Suburban Area In Indonesia: Original Research Gunawan, Catherine; Satriajaya, Anthony; Vatvani, Akhil Deepak; Waren, Kalis; Angela, Angela; Broto, Resza; Kalumpiu, Jane Florida; Tan, Sylvia
Medicinus Vol 12, No 3 (2023): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i1.7363

Background: There was limited data of Atopic Dermatitis (AD) prevalence and its associated factors in Indonesia. Therefore, the aim of this study was to identify and evaluate the AD prevalence and factors associated with AD in elementary school children in suburban area in Banten.Methods: A cross-sectional study was conducted in 3 elementary schools children age 6–7 years old who were randomly selected. Information was obtained through an Indonesian version of the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC).Results: From 304 school children in semi-urban area, AD was reported as ever had an itchy rash which was reccurent for at least 6 months in 17.4% of the children, 19.5% of the children had this itchy rash at any time in the past 12 months, and 11.4 % reported doctor-diagnosed AD. The factors found to be associated with an increased risk of AD were allergic rhinitis (OR 2.151 CI: 1.086-4.261), history of premature birth (<37 weeks) (OR 5.306, CI:1.577-17.858), exclusive breastfeeding (OR 3.126 CI:1.314-7.439), and food allergy (OR 2.912 CI:1.386-6.119).Conclusion: The results of this study showed that allergic rhinitis, history of premature birth (<37 weeks), exclusive breastfeeding, and food allergy were factors associated with AD in Indonesian schoolchildren.

Factors Associated with Low Back Pain in Pre-Clinical Students in the Faculty of Medicine at Pelita Harapan University: Original Research Samudra, Edeline; Kalumpiu, Jane Florida
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8881

Background: Low back pain is one of the most common health problems globally, including in Indonesia, and can result in limitations on a person's activities. While low back pain is typically associated with adults and the elderly, its prevalence is also notably high among students, particularly medical students. Despite the various factors contributing to low back pain, there is limited data on its prevalence and associated factors in Indonesia.Methods: A cross-sectional study was conducted at the Faculty of Medicine, Pelita Harapan University, utilizing consecutive sampling. Data were collected using the Nordic Musculoskeletal Questionnaire, Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire (IPAQ), and Perceived Stress Scale (PSS).Results: Out of 179 students, 144 (80%) experienced low back pain, while 35 (20%) did not. Among students with low back pain, 1.4% had psychological history, 7.3% had history of spinal problems, 0.7% had family history, 15.3% were obese, 75% had poor sleep quality, 8.3% had high-risk physical activity, 6.9% had a high-risk position, and 7.6% had a high-risk stress level. While other factors showed no significant association with low back pain, sleep quality demonstrated a significant association with a p-value of 0.022 (OR 2.52, CI 1.18-5.43).Conclusion: There is a significant association between sleep quality and low back pain in pre-clinical medical students at UPH, while other factors did not exhibit significant correlations.

PROTOZOA OPORTUNISTIK PENYEBAB ENSEFALITIS DAN KERATITIS: ACANTHAMOEBA Halleyantoro, Ryan; Kalumpiu, Jane Florida; Wijaya, Meiliyana
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 1 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Acanthamoeba merupakan kelompok protozoa free-living amoeba (FLA) yang dapat menimbulkan mortalitas tinggi terkait ensefalitis dan kebutaan karena keratitis. Infeksi Acanthamoeba pada manusia dari tahun ke tahun menunjukkan peningkatan jumlah kasus, khususnya sebagai keratitis. Patogenesis Acanthamoeba sebagai penyebab ensefalitis masih belum dipahami sepenuhnya namun, berdasarkan temuan histopatologi kemungkinan melalui jalur transendotelial, rete vasorum, maupun kombinasi keduanya. Patogenesis terjadinya keratitis oleh Acanthamoeba akibat infiltrasi pada epitel kornea hingga menembus stroma di bawahnya yang dapat menyebabkan kerusakan dan memicu peradangan hebat. Kemampuan Acanthamoeba untuk beradaptasi di lingkungan dan mengandung bakteri endosimbion memengaruhi patogenitas dan resistensi terhadap agen terapeutik. Penegakkan diagnosis melalui gambaran klinis didukung isolasi Acanthamoeba melalui pemeriksaan mikroskopis atau kultur atau molekuler yang cermat sangat penting untuk pemberian terapi sedini mungkin. Penatalaksanaan infeksi Acanthamoeba meliputi pemberian antimikroba kombinasi. Diagnosis dan terapi dini yang tepat dapat menurunkan angka morbiditas dan mortalitas akibat infeksi protozoa ini. Kata kunci: Acanthamoeba, ensefalitis, free-living amoeba, keratitis DOI : 10.35990/mk.v8n1.p82-94

Factors Associated With Atopic Dermatitis In Elementary School Children In Suburban Area In Indonesia: Original Research Gunawan, Catherine; Satriajaya, Anthony; Vatvani, Akhil Deepak; Waren, Kalis; Angela, Angela; Broto, Resza; Kalumpiu, Jane Florida; Tan, Sylvia
Medicinus Vol. 12 No. 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.7034

Background: There was limited data of Atopic Dermatitis (AD) prevalence and its associated factors in Indonesia. Therefore, the aim of this study was to identify and evaluate the AD prevalence and factors associated with AD in elementary school children in suburban area in Banten.Methods: A cross-sectional study was conducted in 3 elementary schools children age 6 - 7 years old who were randomly selected. Information was obtained through an Indonesian version of the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC).Results: From 304 school children in semi-urban area, AD was reported as ever had an itchy rash which was reccurent for at least 6 months in 17.4% of the children, 19.5% of the children had this itchy rash at any time in the past 12 months, and 11.4 % reported doctor-diagnosed AD. The factors found to be associated with an increased risk of AD were allergic rhinitis (OR 2.151 CI: 1.086-4.261), history of premature birth (<37 weeks) (OR 5.306, CI:1.577-17.858), exclusive breastfeeding (OR 3.126 CI:1.314-7.439), and food allergy (OR 2.912 CI:1.386-6.119).Conclusion: The results of this study showed that allergic rhinitis, history of premature birth (<37 weeks), exclusive breastfeeding, and food allergy were factors associated with AD in Indonesian schoolchildren.

Factors Associated With Atopic Dermatitis In Elementary School Children In Suburban Area In Indonesia: Original Research Gunawan, Catherine; Satriajaya, Anthony; Vatvani, Akhil Deepak; Waren, Kalis; Angela, Angela; Broto, Resza; Kalumpiu, Jane Florida; Tan, Sylvia
Medicinus Vol. 12 No. 3 (2023): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v11i1.7363

Background: There was limited data of Atopic Dermatitis (AD) prevalence and its associated factors in Indonesia. Therefore, the aim of this study was to identify and evaluate the AD prevalence and factors associated with AD in elementary school children in suburban area in Banten.Methods: A cross-sectional study was conducted in 3 elementary schools children age 6-7 years old who were randomly selected. Information was obtained through an Indonesian version of the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC).Results: From 304 school children in semi-urban area, AD was reported as ever had an itchy rash which was reccurent for at least 6 months in 17.4% of the children, 19.5% of the children had this itchy rash at any time in the past 12 months, and 11.4 % reported doctor-diagnosed AD. The factors found to be associated with an increased risk of AD were allergic rhinitis (OR 2.151 CI: 1.086-4.261), history of premature birth (<37 weeks) (OR 5.306, CI:1.577-17.858), exclusive breastfeeding (OR 3.126 CI:1.314-7.439), and food allergy (OR 2.912 CI:1.386-6.119).Conclusion: The results of this study showed that allergic rhinitis, history of premature birth (<37 weeks), exclusive breastfeeding, and food allergy were factors associated with AD in Indonesian schoolchildren.

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