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All Journal Journal of Experimental and Clinical Pharmacy (JECP) Journal of Biomedical Sciences and Health
Andyra, Vania Uly
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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In Silico Exploration of Suruhan Leaves (Peperomia pellucida) for Triple-Negative Breast Cancer Therapy Targeting AURKA Rovik, Anwar; Andyra, Vania Uly; Afifah, Laelatul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1119

Abstract

Breast cancer is the most common type of cancer worldwide. One of the most widely used chemotherapeutic agents in the treatment of breast cancer is doxorubicin. However, doxorubicin has been reported to cause side effects. Suruhan (Peperomia pellucida) contains bioactive compounds that might protect against breast cancer cells. This study aims to analyze the bioactive compound activity of Suruhan leaves in triple-negative breast cancer in silico. The study was conducted by reviewing published literature on bioactive compounds in Suruhan leaves, predicting the protein target, analyzing the gene expression in triple-negative breast cancer (TNBC) patients, analyzing the protein interactions, and examining patient survival. There are five common bioactive compounds in Suruhan leaves, including peperomin A; 6,8-dihydroxy kaempferol 3,6,7,4'-tetramethyl ether 8-neohesperidoside; dillapiole; carotol; and pellucidin A. AURKA is a target protein for bioactive compounds that are also overexpressed in TNBC patients. AURKA has strong interactions with many proteins, including TPX2, NEDD9, CCNB2, CDC20, PLK1, BIRC5, INCENP, TACC3, TP53, and MYCN. The AURKA has emerged as a promising target for TNBC therapy.
Ethnobotany and Potential of Suruhan (Peperomia pellucida) as a Herbal Medicine Ingredient Rovik, Anwar; Andyra, Vania Uly; Afifah, Laelatul; Rokhmalia, Nur
Journal of Biomedical Sciences and Health Vol. 1 No. 1 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i1.3

Abstract

Background: People have long utilized various herbs for traditional medicine, including the suruhan or sirih cina plant (Peperomia pellucida). This plant is known by numerous local names such as rumput cacing, sirih bumi, pansit-pansitan, rumput gelas, and daing siheah cino. It is widely distributed in tropical and subtropical regions, including Indonesia, making the raw materials easily accessible for herbal medicine. Objective: This study aims to review the ethnobotany and the pharmacological potential of Peperomia pellucida as a natural ingredient for herbal medicine. Methods: This article is a narrative review that synthesizes various literatures regarding the traditional uses, phytochemical content, and biological activities of the suruhan plant. Results: The suruhan plant is used in traditional medicine through various preparation methods depending on the ailment, with the leaves being the most frequently utilized part. Phytochemical analysis reveals that it contains abundant bioactive compounds, including alkaloids, flavonoids, sterols, tannins, reducing sugars, amino acids, saponins, triterpenoids, carbohydrates, phenols, azulene, carotenoids, and quinones. These compounds contribute to its wide-spectrum antibacterial, antifungal, and anticancer activities. Conclusion: Peperomia pellucida holds significant potential as a herbal medicine ingredient due to its rich bioactive content and its long-standing history of traditional use. Accelerated industrial development and government support are needed to optimize its utilization in the healthcare sector.
Co-Authors Afifah, Laelatul Rokhmalia, Nur Rovik, Anwar