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All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal of Experimental and Clinical Pharmacy (JECP) Prosiding University Research Colloquium Journal of Biomedical Sciences and Health
Afifah, Laelatul
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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In Silico Exploration of Suruhan Leaves (Peperomia pellucida) for Triple-Negative Breast Cancer Therapy Targeting AURKA Rovik, Anwar; Andyra, Vania Uly; Afifah, Laelatul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 2 (2024): August 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i2.1119

Abstract

Breast cancer is the most common type of cancer worldwide. One of the most widely used chemotherapeutic agents in the treatment of breast cancer is doxorubicin. However, doxorubicin has been reported to cause side effects. Suruhan (Peperomia pellucida) contains bioactive compounds that might protect against breast cancer cells. This study aims to analyze the bioactive compound activity of Suruhan leaves in triple-negative breast cancer in silico. The study was conducted by reviewing published literature on bioactive compounds in Suruhan leaves, predicting the protein target, analyzing the gene expression in triple-negative breast cancer (TNBC) patients, analyzing the protein interactions, and examining patient survival. There are five common bioactive compounds in Suruhan leaves, including peperomin A; 6,8-dihydroxy kaempferol 3,6,7,4'-tetramethyl ether 8-neohesperidoside; dillapiole; carotol; and pellucidin A. AURKA is a target protein for bioactive compounds that are also overexpressed in TNBC patients. AURKA has strong interactions with many proteins, including TPX2, NEDD9, CCNB2, CDC20, PLK1, BIRC5, INCENP, TACC3, TP53, and MYCN. The AURKA has emerged as a promising target for TNBC therapy.
Gambaran Stigma Masyarakat Pada Kasus Covid-19 Di Desa Sukorejo Kecamatan Ulujami Kabupaten Pemalang Afifah, Laelatul; Arifin, Mokhamad
Prosiding University Research Colloquium Proceeding of The 16th University Research Colloquium 2022: Mahasiswa (Student Paper Presentation)
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Pandemi covid-19 membuat berbagai perubahan pada setiap aspek kehidupan, salah satunya tentang stigma masayarakat mengenai Covid-19 hal ini dikarenakan masih banyak masyarakat yang berfikiran salah tentang Covid-19. Mendeskripsikan stigma masyarakat terhadap Covid-19. Sampel yang diambil dalam penelitian ini sebanyak 364 responden dengan teknik cluster sampling dengan kriteria inklusi dan eksklusi di Desa Sukorejo Kecamatan Ulujami Kabupaten Pemalang. Penelitian ini adalah penelitian kuantitatif dengan desain mendiskripsikan variabel penelitian. Hasil penelitian ini menunjukkan Gambaran Stigma Masyarakat Pada Kasus COVID-19 Didesa Sukorejo Kecamatan Ulujami Kabupaten Pemalang Hasil penelitian didapatkan sebesar 183 responden (50,3%) memiliki stigma pada kasus COVID-19 dan 181 responden (49,7%) tidak stigma pada kasus COVID-19 Didesa Sukorejo Kecamatan Ulujami Kabupaten Pemalang. Gambaran Stigma Masyarakat Pada Kasus Covid-19 Di Desa Sukorejo Kecamatan Ulujami Kabupaten Pemalang didapatkan hasil masyarakat memiliki stigma pada kasus Covid-19.
Ethnobotany and Potential of Suruhan (Peperomia pellucida) as a Herbal Medicine Ingredient Rovik, Anwar; Andyra, Vania Uly; Afifah, Laelatul; Rokhmalia, Nur
Journal of Biomedical Sciences and Health Vol. 1 No. 1 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i1.3

Abstract

Background: People have long utilized various herbs for traditional medicine, including the suruhan or sirih cina plant (Peperomia pellucida). This plant is known by numerous local names such as rumput cacing, sirih bumi, pansit-pansitan, rumput gelas, and daing siheah cino. It is widely distributed in tropical and subtropical regions, including Indonesia, making the raw materials easily accessible for herbal medicine. Objective: This study aims to review the ethnobotany and the pharmacological potential of Peperomia pellucida as a natural ingredient for herbal medicine. Methods: This article is a narrative review that synthesizes various literatures regarding the traditional uses, phytochemical content, and biological activities of the suruhan plant. Results: The suruhan plant is used in traditional medicine through various preparation methods depending on the ailment, with the leaves being the most frequently utilized part. Phytochemical analysis reveals that it contains abundant bioactive compounds, including alkaloids, flavonoids, sterols, tannins, reducing sugars, amino acids, saponins, triterpenoids, carbohydrates, phenols, azulene, carotenoids, and quinones. These compounds contribute to its wide-spectrum antibacterial, antifungal, and anticancer activities. Conclusion: Peperomia pellucida holds significant potential as a herbal medicine ingredient due to its rich bioactive content and its long-standing history of traditional use. Accelerated industrial development and government support are needed to optimize its utilization in the healthcare sector.
Antibiofilm Activities of Bioactive Compounds of Local Edible Flowers in Indonesia: A Review Rovik, Anwar; Afifah, Laelatul; Rokhmalia, Nur; Andyra, Vania Uly; Richad, Richad
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.84411

Abstract

Antimicrobial resistance is a growing global health problem. Biofilm formation is a notable risk factor for patient mortality. Various efforts are needed to prevent biofilm formation. Plants have been utilized in traditional medicine practices for centuries. In this review, we present an ethnobotanical study of the use of edible flowers in Indonesia and their potential development as antibiofilm agents. Local communities in Indonesia have long used various flowering plants for traditional ceremonial purposes, aesthetics, cooking ingredients, and medicine. Only a few types of flowers are utilized as food ingredients or edible flowers. There are 25 types of edible flowers from 19 families in Indonesia. Not all edible flowers in Indonesia have been studied for their antibiofilm activities. The presence of bioactive compounds, e.g., alkaloids, saponins, steroids, terpenoids, flavonoids, and phenolics in edible flowers, suggests that they may have the potential to inhibit biofilm formation. Local communities also use edible flowers in traditional medicine practices, including Hibiscus sabdariffa, Jasminum sambac, Caesalpinia pulcherrima, Punica granatum, Blumea balsamifera, and Lantana camara. The bioactive compounds showed antimicrobial activity against Gram-positive and Gram-negative bacteria, including Acinetobacter baumannii, Vibrio cholerae, Staphylococcus aureus, Bacillus cereus, Listeria spp., Streptococcus spp., Enterococcus faecalis, Salmonella typhi, Shigella dysenteriae, Escherichia coli, Klebsiella spp., Proteus spp., Porphyromonas gingivalis, and Treponema denticola. We also highlight the need for further research to explore more edible flowers and their specific effects of the compounds on biofilm formation.
Co-Authors Andyra, Vania Uly Mokhamad Arifin Richad, Richad Rokhmalia, Nur Rovik, Anwar