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An Overview of Traditional Medicinal Plants Used in Treating Hepatocellular Carcinoma (HCC) with Emphasis on Mechanisms of Action: Traditional Medicinal Treatment of Hepatocellular Carcinoma (HCC) Adekilekun, Habeebulahi Ajibola; Oyewusi, Habeebat A.; Odoma, Saidi; Kirimuhuzya, Claude
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.20

Cancer is an incurable fatal disease wreaking havoc on the population of countries either developed or developing. Hepatocellular carcinoma (HCC) is the fifth most frequent type of cancer having a poor prognosis. Globally, HCC management and treatment intervention using medicinal plants from generation to generation is rapidly increasing and remains an area of promising research. This review provided insight into medicinal plants' ethnomedicinal use, photochemistry and mechanisms of action on HCC exhibiting anti-cancer potentials subjected to scientific investigations. Furthermore, clinical, toxicity studies and detailed mechanisms of action would provide an understanding of the development of lead compounds in drug discovery and development for HCC

An Overview of Traditional Medicinal Plants Used in Treating Hepatocellular Carcinoma (HCC) with Emphasis on Mechanisms of Action: Traditional Medicinal Treatment of Hepatocellular Carcinoma (HCC) Adekilekun, Habeebulahi Ajibola; Oyewusi, Habeebat A.; Odoma, Saidi; Kirimuhuzya, Claude
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.20

Cancer is an incurable fatal disease wreaking havoc on the population of countries either developed or developing. Hepatocellular carcinoma (HCC) is the fifth most frequent type of cancer having a poor prognosis. Globally, HCC management and treatment intervention using medicinal plants from generation to generation is rapidly increasing and remains an area of promising research. This review provided insight into medicinal plants' ethnomedicinal use, photochemistry and mechanisms of action on HCC exhibiting anti-cancer potentials subjected to scientific investigations. Furthermore, clinical, toxicity studies and detailed mechanisms of action would provide an understanding of the development of lead compounds in drug discovery and development for HCC

Evaluation of Acute and Subacute Oral Toxicity of Erlangea tomentosa (Oliv. & Hiern) S. Moore (Asteraceae) Methanol Leaf Extract in Experimental Wistar Albino Rats Mboneye, Anselme; Onchweri, Albert Nyanchoka; Neeza, Timothy; Odoma, Saidi
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 1 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i1.610

Erlangea tomentosa (Oliv. & Hiern) S. Moore's leaves, which are in the Asteraceae family, were tested for acute and subacute toxicity in experimental Wistar rats. Lorke’s (bi-phasic) method was used to evaluate the acute toxicity profile of the plant extract. In phase 2, twelve rats of both sexes were administered a maximum dosage of 5000 mg/kg of extract. Observations of toxicity signs were made and recorded for 2 hours consecutively, for 24 hours intermittently, as well as for the next 14 days. For the subacute study, rats were orally administered water and plant extract daily for 28 days. Toxicological effects were recorded daily, and body weights were documented weekly. Hematological, biochemical, and histopathological tests as well as relative organ weights were evaluated at the conclusion of the study. In phase 2 of the acute toxicity study, it was found that the plant extract was toxic at doses of 1600, 3100, and 5000 mg/kg, with only one death at the highest dose. In the subacute toxicity study, animals that were administered 800 mg/kg of extract for 28 days showed symptoms of toxicity. The weight of the kidneys increased; urea and ALT levels increased; as well as total protein and albumin levels decreased compared to the control group. At the same dose, histopathology examination revealed alterations of the liver and kidneys, while hematopoietic cells were significantly disrupted compared to the control animals. Based on the findings, the methanol-extracted leaves of E. tomentosa showed a moderate level of acute toxicity. The administration of the extract at a dose of 400 mg/kg was safe, but 800 mg/kg was toxic. This caused damage to their livers and kidneys. This led to an increase in ALT and ALP, changes in blood parameters like Hb, RBC, and PLT, as well as the development of inflammatory cells.

Comprehensive In-silico Pharmacodynamic and Pharmacokinetics of Phytochemicals from Newbouldia laevis : In-silico Pharmacodynamic and Pharmacokinetics of Newbouldia laevis Adekilekun, Habeebulahi Ajibola; Oyewusi, Habeebat Adekilekun; Huyop, Fahrul; Igbinoba, Sharon; Odoma, Saidi; Onohuean, Hope; Guna,, Ida Bagus Wayan
Journal of Tropical Life Science Vol. 16 No. 01 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.01.12

Medicinal plants with the therapeutic properties like Newbouldia laevis, where its pharmacological attribute is related to the existence of various bioactive compounds. This present study evaluates the physicochemical, drug likeness, pharmacokinetic factors (ADMET), pharmacodynamic factors (biological activity) and pharmacophore analysis of N. laevis phytochemicals by instrumentation of in-silico computational online webservers including SwissADME and ADMETlab2, ProToxII and StopTox, PASS online and ZINCPharmar webservers. The study revealed that 47 phytochemicals were identified from Newbouldia laevis based on the literature search. Based on our findings the 3-Dimentional (3D) structures and canonical SMILES identity of 40 and 44 respectively out of 47 phytochemicals that were found documented at PubChem and ChemSpider databases. Therefore, further analysis was based on the phytochemicals with the reported 3D structures and canonical SMILES identity. All the investigated N. laevis phytochemicals obey Lipinski's rule of five (RO5) except Newbouldiamide, stigmasterol glucoside and beta-sitosterol-3-O-D-Glucopyranoside. The present study disclosed that almost all phytochemicals tend to show decent smooth membrane permeability, oral bioavailability, and high gastrointestinal absorption in human gut. Moreover, these phytochemicals showed excellent bioactivity of enzyme inhibition for treatment of various diseases especially cancer. Lastly, the pharmacophore study revealed the functional descriptors in which almost all the phytochemicals one or more H bond donors, H bond acceptors, aromatic group, and hydrophobic bonds were identified as common descriptors except 1,2,3,4-Butanetetrol. Hence, in-silico results permit us to agree that identified phytochemicals from N. laevis are predicted to be a prospective upcoming drug candidate, particularly through oral administration, owing to its germane Drug-likeness profile, excellent liposolubility, bioavailability, and adequate bioactivity, pharmacokinetics, and pharmacological profile.

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