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All Journal NURSING UPDATE JURNAL ILMIAH ILMU KEPERAWATAN Jurnal Kesehatan dr. Soebandi
Umar, Rizal
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Evaluasi Efek Samping Penggunaan Obat Tetes Mata Kortikosteroid Pada Pasien Pasca Operasi Katarak (Penelitian dilakukan di Instalasi Farmasi Klinik Mata KMU Madura) Solihah, Riyadatus; Umar, Rizal
NURSING UPDATE : Jurnal Ilmiah Ilmu Keperawatan P-ISSN : 2085-5931 e-ISSN : 2623-2871 Vol 15 No 3 (2024): SEPTEMBER
Publisher : NHM PRESS

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Abstract

Corticosteroids are natural steroid hormones in humans produced by the adrenal cortex gland that have a function to treat inflammation or autoimmune disorders in the body. In the case of eye disease, corticosteroid drugs can take the form of eye drops that are widely used in post-cataract surgery patients, which function to reduce inflammation that occurs in the interior segment which sometimes has no clear cause. The purpose of this study was to determine the side effects that can occur in the use of corticosteroid drugs after cataract surgery. This study was conducted with crossectional method which was analysed descriptively using universal sampling method. This activity uses inclusion and exclusion criteria. The sampling method uses non-random sampling with the time limited sampling method, namely taking all patient's Health Medical Record (RMK) data. The results and discussion of this study were conducted at the KMU Madura Clinic Pharmacy Installation involving a number of post-cataract surgery patients who used corticosteroid eye drops. The use of corticosteroid eye drops has the potential to cause various side effects. The most common side effects encountered in patients are blurring, stinging, red eyes, and itching. The most widely used eye drops were prednisolone by 53.3%. Based on the above results, it can be described that the length of use of corticosteroid eye drops in patients after cataract surgery at the KMU madura eye clinic pharmacy installation is more than 30 days.
Pengaruh Lama Penggunaan Kb Suntik (DMPA) Terhadap Kadar Low Density Lipoprotein (LDL-C) Solihah, Riyadatus; Umar, Rizal
NURSING UPDATE : Jurnal Ilmiah Ilmu Keperawatan P-ISSN : 2085-5931 e-ISSN : 2623-2871 Vol 13 No 2 (2022): JUNI
Publisher : NHM PRESS

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Abstract

DMPA may cause increased lipophysis or hydrolysis. Then the large amount of free fatty acids is carried to the liver, causing increased triglyceride synthesis and VLDL secretion. In the state of insulin resistance VLDL becomes increased in circulation and can cause an increase in Low Density Lipoprotein (LDL), LDL is mostly formed from VLDL. The purpose of this study was to determine the effect of injectable birth control (DMPA) on Low Density Lipoprotein (LDL) levels. The research method used in this study is analytic with a cross sectional approach. The technique used was purposive sampling in a population of 60 respondents and a sample of 24 respondents in women who used DMPA injectable birth control in Ponkesdes Fariyah.S.ST. The results obtained from 24 samples showed as many as 12 samples (50%) using DMPA injections above 3 years had higher LDL cholesterol levels compared to 12 samples (50%) using DMPA injections above 5 years. The results of statistical tests conducted with the Independent Samples Test test obtained a significant value of 0.793 (p ≥ 0.05) so it can be concluded that there is no difference in LDL-cholesterol levels in the use of injectable birth control for more than 3 years and more than 5 years. For women who use DMPA injectable birth control, it is advisable to check LDL levels more often so that the LDL levels in the blood can be known.
The Effect of Curcuma Extract Emulsion as an Amara on Ghrelin Hormone Profiles and Increased Feed Consumption in Male Rats Riyadatus Solihah; Umar, Rizal
Jurnal Kesehatan dr. Soebandi Vol 14 No 1 (2026): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v14i1.1119

Abstract

Background :   Curcuma (Curcuma xanthorrhiza Roxb.) contains curcuminoids and essential oils that aid bile and pancreatic function, thereby improving food absorption in the intestines and increasing appetite. However, the underlying biological mechanisms of the hormones that regulate hunger and satiety have not been extensively reported. This study aims to analyze the appetite-suppressing mechanism of curcuma rhizome extract emulsion by observing changes in ghrelin hormone levels in male Wistar rats. Methods :   This study was an experimental study using a post-test only control group design. The test animals were divided into four groups: negative control (distilled water), and three treatment groups that received curcuma extract emulsion at different concentrations (10%, 20%, and 30%). The treatment was administered orally for 21 days. The parameters obtained included ghrelin levels in serum, which were analyzed using the ELISA method, while additional parameters included daily feed intake and weight change. The data obtained were analyzed using normality and homogeneity tests, followed by one-way ANOVA and post-hoc tests. Results: This study shows that administration of curcuma extract emulsion can enhance the effects of amara, as seen from increased feed intake and body weight, and by increased ghrelin levels when compared to the control. Conclusions: This study concluded that curcuma functions as an appetite stimulant through hormonal pathways, which has the potential to be developed as a phytopharmaceutical candidate to increase appetite through a mechanism-based approach.
Co-Authors Solihah, Riyadatus