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All Journal Journal of Telenursing (JOTING) JAMAS: Jurnal Abdi Masyarakat
Cristy, Devina Wahyu Astaning
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Agriculture, Biological Sciences & Forestry Humanities Health Professions Nursing Social Sciences

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Simvastatin dengan Senyawa Turunan Β-Siklodextrin Cristy, Devina Wahyu Astaning; Harmastuti, Nuraini; Mardiyono, Mardiyono
Journal of Telenursing (JOTING) Vol 6 No 1 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i1.9472

Abstract

This study aims to determine the profile of the inclusion complex formed between simvastatin and β-cyclodextrin and its derivatives. To determine the level of stability and determine the solubility level of the inclusion complex formed between simvastatin and β-cyclodextrin and its derivatives (2-hydroxypropyl-β-cyclodextrin and 2,6-di-O-methyl-β-cyclodextrin) in water solvent.The method used is qualitative descriptive using the molecular docking method, modeling and anchoring the inclusion complex model.The research results show that the simvastatin/HP-β-CD inclusion complex has a higher level of solubility in water solvents compared to the simvastatin/β-CD and simvastatin/DM-β-CD inclusion complexes, with a ΔGsolvation value of -1032.34 kJ/mol.Conclusion: Simvastatin is able to bind to the cavity of 2-hydroxypropyl-β-cyclodextrin, 2,6-di-O-methyl-β-cyclodextrin, and simvastatin/β-cyclodextrin with the following order of bond strength: simvastatin/2-hydroxypropyl-β -cyclodextrin > simvastatin/2,6-di-O-methyl-β-cyclodextrin > simvastatin/β-cyclodextrin. Keywords: Inclusion Complex, Molecular Docking, Molecular Dynamics Simulation, Β-Cyclodextrin, Simvastatin.
STANDARISASI MUTU DAN LEGALITAS P-IRT PRODUK TEH HERBAL DI DESA PETUNGSEWU : Quality Standardization and P-IRT Legality Herbal Tea Products in Petungsewu Village Cristy, Devina Wahyu Astaning; Puspitasari, Diny; Irawan, Yanuar Hadi; Rahmawati, Yunita
JAMAS : Jurnal Abdi Masyarakat Vol. 4 No. 1 (2026)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62085/jms.v4i1.236

Abstract

Indonesia memiliki kekayaan biodiversitas tanaman obat yang besar, namun pemanfaatannya di tingkat industri rumah tangga seringkali belum memenuhi standar mutu dan legalitas yang konsisten. Masalah utama di Desa Petungsewu adalah kurangnya pemahaman mitra mengenai stabilitas zat aktif antosianin dan katekin yang sensitif terhadap suhu tinggi di atas 70°C, serta ketiadaan izin edar P-IRT. Kegiatan pengabdian ini bertujuan untuk melakukan Standardisasi mutu dan legalitas produk teh herbal "Vinawa" milik kelompok PKK Desa Petungsewu. Metode yang digunakan adalah Sequential Transformative Approach yang meliputi diseminasi informasi, workshop partisipatif dengan kontrol suhu pengeringan di bawah 50°C, serta asistensi mandiri pendaftaran akun OSS-RBA. Hasil kegiatan menunjukkan adanya transformasi pengetahuan mitra dalam menerapkan kontrol suhu presisi untuk menjaga stabilitas zat aktif dan keberhasilan penerbitan nomor izin edar P-IRT: 6083573012532-30. Kesimpulannya, kegiatan ini berhasil meningkatkan profesionalisme pelaku UMKM melalui pemenuhan aspek legalitas dan standarisasi mutu produk pangan fungsional secara berkelanjutan.
Co-Authors Fachry Abda El Rahman Irawan, Yanuar Hadi Nuraini Harmastuti Puspitasari, Diny Yunita Rahmawati