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All Journal Journal of Telenursing (JOTING) Pharmademica: Jurnal Kefarmasian dan Gizi JAMAS: Jurnal Abdi Masyarakat
Cristy, Devina Wahyu Astaning
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Agriculture, Biological Sciences & Forestry Humanities Chemistry Health Professions Nursing Public Health Social Sciences

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Simvastatin dengan Senyawa Turunan Β-Siklodextrin Cristy, Devina Wahyu Astaning; Harmastuti, Nuraini; Mardiyono, Mardiyono
Journal of Telenursing (JOTING) Vol 6 No 1 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i1.9472

Abstract

This study aims to determine the profile of the inclusion complex formed between simvastatin and β-cyclodextrin and its derivatives. To determine the level of stability and determine the solubility level of the inclusion complex formed between simvastatin and β-cyclodextrin and its derivatives (2-hydroxypropyl-β-cyclodextrin and 2,6-di-O-methyl-β-cyclodextrin) in water solvent.The method used is qualitative descriptive using the molecular docking method, modeling and anchoring the inclusion complex model.The research results show that the simvastatin/HP-β-CD inclusion complex has a higher level of solubility in water solvents compared to the simvastatin/β-CD and simvastatin/DM-β-CD inclusion complexes, with a ΔGsolvation value of -1032.34 kJ/mol.Conclusion: Simvastatin is able to bind to the cavity of 2-hydroxypropyl-β-cyclodextrin, 2,6-di-O-methyl-β-cyclodextrin, and simvastatin/β-cyclodextrin with the following order of bond strength: simvastatin/2-hydroxypropyl-β -cyclodextrin > simvastatin/2,6-di-O-methyl-β-cyclodextrin > simvastatin/β-cyclodextrin. Keywords: Inclusion Complex, Molecular Docking, Molecular Dynamics Simulation, Β-Cyclodextrin, Simvastatin.
STANDARISASI MUTU DAN LEGALITAS P-IRT PRODUK TEH HERBAL DI DESA PETUNGSEWU : Quality Standardization and P-IRT Legality Herbal Tea Products in Petungsewu Village Cristy, Devina Wahyu Astaning; Puspitasari, Diny; Irawan, Yanuar Hadi; Rahmawati, Yunita
JAMAS : Jurnal Abdi Masyarakat Vol. 4 No. 1 (2026)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62085/jms.v4i1.236

Abstract

Indonesia memiliki kekayaan biodiversitas tanaman obat yang besar, namun pemanfaatannya di tingkat industri rumah tangga seringkali belum memenuhi standar mutu dan legalitas yang konsisten. Masalah utama di Desa Petungsewu adalah kurangnya pemahaman mitra mengenai stabilitas zat aktif antosianin dan katekin yang sensitif terhadap suhu tinggi di atas 70°C, serta ketiadaan izin edar P-IRT. Kegiatan pengabdian ini bertujuan untuk melakukan Standardisasi mutu dan legalitas produk teh herbal "Vinawa" milik kelompok PKK Desa Petungsewu. Metode yang digunakan adalah Sequential Transformative Approach yang meliputi diseminasi informasi, workshop partisipatif dengan kontrol suhu pengeringan di bawah 50°C, serta asistensi mandiri pendaftaran akun OSS-RBA. Hasil kegiatan menunjukkan adanya transformasi pengetahuan mitra dalam menerapkan kontrol suhu presisi untuk menjaga stabilitas zat aktif dan keberhasilan penerbitan nomor izin edar P-IRT: 6083573012532-30. Kesimpulannya, kegiatan ini berhasil meningkatkan profesionalisme pelaku UMKM melalui pemenuhan aspek legalitas dan standarisasi mutu produk pangan fungsional secara berkelanjutan.
Optimasi PVA dan HPMC dalam Masker Wajah Gel Peel Off Ekstrak Daun Beluntas (Pluchea indica L.) dengan Metode Simplex Lattice Design Puspitasari, Diny; Cristy, Devina Wahyu Astaning; Langu, Fina Arista
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.158

Abstract

Peel-off gel masks are widely used cosmetic skincare preparations due to their practicality, ease of removal, and non-comedogenic properties. Beluntas (Pluchea indica L.) leaf contains various bioactive compounds, particularly flavonoids, which possess antibacterial activity. This study aimed to obtain the optimum formulation of a peel-off face mask containing Beluntas leaf extract, with variations in Polivinyl alcohol (PVA) as a film-forming agent, and hydroxypropyl methylcellulose (HPMC) as a gelling agent.This experimental study employed the Simplex Lattice Design (SLD), an optimization method. Five formulations were prepared with PVA content ranging from 10-16% and HPMC concentrations from 2-4%. Each formulation was evaluated for organoleptic properties, homogeneity, pH, spreadability, drying time, adhesion, and viscosity, and the data were analyzed using Design Expert Version 13. The optimum peel-off gel mask formulation containing Beluntas leaf extract was obtained at PVA 12.92% and HPMC 3.07% with predicted spreading power 5.198, adhesion 52.910, viscosity 586.357, pH 4.626, drying time 23.502 with desirability 0.812.
Co-Authors Fachry Abda El Rahman Irawan, Yanuar Hadi Langu, Fina Arista Nuraini Harmastuti Puspitasari, Diny Yunita Rahmawati