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All Journal Sriwijaya Journal of Ophthalmology
Oscar, Alexander
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Retinal Detachment Following Vaccination against COVID-19: A Narrative Literature Review Markov, Gueorgui; Yani Zdravkov; Oscar, Alexander
Sriwijaya Journal of Ophthalmology Vol. 6 No. 2 (2023): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v6i2.108

Abstract

Retinal detachment (RD) refers to the anatomical separation of the neurosensory retina from the Retinal pigment epithelium, which, if untreated, ultimately leads to a loss of visual function and blindness. Three main types are recognised based on the pathogenesis: rhegmatogenous, associated with retinal tears/holes; tractional, where there is pulling on the retina from preretinal and/or vitreal fibrotic changes; and exudative or serous, in which the subretinal fluid is due to transudation, exudation, or impaired outer blood-retina barrier. The infection with SARS-CoV-2 has not been directly associated with any type of RD, except in cases of secondary infections or autoimmune conditions. Serous retinal detachment has very rarely been observed following the application of various vaccines against COVID-19, but only in the setting of central serous chorioretinopathy and uveitis. The single case of purported rhegmatogenous detachment has a highly improbable connection with the vaccination. All in all, the described complications have been extremely uncommon, more frequently treatable or self-resolving, and should not discourage COVID-19 vaccination.
Helicobacter pylori and Uveitis: A Brief Narrative Literature Review Markov, Gueorgui; Yani Zdravkov; Oscar, Alexander
Sriwijaya Journal of Ophthalmology Vol. 6 No. 2 (2023): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v6i2.109

Abstract

Helicobacter pylori (H. pylori) is a gram-negative bacterium that typically infects the mucosa of the stomach. H. pylori is the most frequent causative infectious agent of chronic gastritis and peptic ulcer disease. It has also been associated with a number of extra-gastric diseases-neurological, ocular, hematologic, cardiovascular, rheumatologic, metabolic, and allergic. The possible role of H. pylori in the pathogenesis of uveitis is still unclear. High H. pylori seroprevalence has been found in some studies in patients with other ocular diseases like blepharitis, central serous chorioretinopathy, ocular adnexal lymphoma, and glaucoma. Its seroprevalence in uveitis has been investigated in very few studies. In all of them, however, it was increased. Antibodies have also been found in the anterior chamber of patients with anterior uveitis. Besides, seropositivity was also increased in studies with hypertensive uveitis. Eradication of the bacterium has anecdotally led to the subsidence of anterior uveitis in one patient. In any case, a causal relationship, either infectious or autoimmune, cannot be made at this time due to the scarcity of available research on the problem.
Co-Authors Markov, Gueorgui Yani Zdravkov