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All Journal Jurnal Biologi Tropis Journal of Clinical Microbiology and Infectious Diseases
Wijaya, Carolin
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Prevalence of uropathogen producing extended spectrum beta lactamase (ESBL) at urinary tract infection in chronic kidney disease patients Wijaya, Carolin; Eriata, Anselmus Helbert; Rustawan, I Nengah Tony; Candra, I Kadek Bayu Adhi; Budayanti, Ni Nyoman Sri
Journal of Clinical Microbiology and Infectious Diseases Vol. 3 No. 1 (2023): Available online : June 2023
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v3i1.29

Abstract

Background: Urinary tract infection (UTI) is one of the most common bacterial infections encountered by clinicians in developing countries. UTI in patients with Chronic Kidney Disease (CKD) caused by ESBL-producing gram-negative bacteria has been increased in different countries. The common uropathogenic Gram negative bacteria are Escherichia coli and Klebsiella pneumoniae. The aim of this study was to identify prevalence of the common uropathogen producing ESBL E. coli and K. pneumonia among the patients with urinary tract infection (UTI) in chronic kidney disease as well as the susceptibility of antibiotic therapy. Methods: This was a cross-sectional retrospective study to evaluate clinical urine isolates collected from Prof. Dr. I.G.N.G. Ngoerah Hospital within July 2019 until July 2020. Identification and susceptibility tests in urine isolate were performed by Vitex-2 System (Biomerieux) and interpreted with CLSI 2020 standard. Results: From 1291 urine specimens,  210 urine specimens were collected (29.43%) from patients with UTI in CKD  during 12 months. Prevalence of uropathogen in chronic kidney disease from urine specimens were E.coli (41.57%), K.pneumoniae (13.15%), and Pseudomonas aeruginosa  (7.36%). It was found that ESBL produced E. coli (56.32%) and also K. pneumoniae (54%). Susceptibility antibiotic E. coli and K. pneumonia of UTI patient with CKD with ESBL producers were meropenem (99,10%), amikacin (98,07%), tigecycline (92,30%), gentamicin (80%), and fosfomycin (79,47%). Conclusion: ESBL producers in patient UTI in CKD patients were E. coli 56,32%, K. pneumoniae 54% that were sensitive to meropenem, amikacin, tigecycline gentamicin, fosfomycin.
Antibacterial Activity Test of Star Fruit Leaf Extract (Averrhoa bilimbi Linn) Against Staphylococcus epidermidis Elsen, Michellin; Rini, Desi Indria; Riwu, Magdarita; Wijaya, Carolin
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11238

Abstract

Staphylococcus epidermidis is a normal flora bacteria on the skin that can cause opportunistic infections. Generally, this infection is treated using antibiotics, but improper use of antibiotics can cause the onset of antibiotic resistance, so the development of natural antibacterial research with plant materials is one of the alternatives to reduce the incidence of resistance. A traditional medicinal plant is the leaves of star fruit (Averrhoa bilimbi Linn). This research aimed to investigate the antibacterial properties of the extract from star fruit leaves on Staphylococcus epidermidis. The type of research used is a true experimental design with a post-test only control group design. The treatment group in this study consisted of concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.12%, with a positive control of clindamycin at a dose of 2 μg and a negative control of sterile aquadest which was carried out 3 times for each test group. The antibacterial test method is carried out by the disc diffusion method. The data analysis used is the One Way Anova statistical test. Star fruit leaf extract contains alkaloid compounds, tannins, saponins, flavonoids, and steroids. There is antibacterial activity of star fruit leaf extract against Staphylococcus epidermidis. The inhibition zone was produced at various concentrations of 100% (⌀ 15.14 mm), 50% (⌀ 14.06 mm), 25% (⌀ 13.75 mm), 12.5% (⌀ 12.01 mm), 6.25% (⌀ 10.55 mm), and 3.12% (⌀ 9.03 mm). Starfruit leaf extract has antibacterial activity against Staphylococcus epidermidis.
Co-Authors Candra, I Kadek Bayu Adhi Elsen, Michellin Eriata, Anselmus Helbert Ni Nyoman Sri Budayanti Rini, Desi Indria Riwu, Magdarita Rustawan, I Nengah Tony